Abstract: The present disclosure pertains to a mammalian cell culture genetically modified to express, and which expresses, a neublastin antibody polypeptide, or fragment thereof, in the culture, and to a neublastin antibody polypeptide, or fragment thereof, made by a mammalian cell culture genetically modified to express, and which expresses, the neublastin antibody polypeptide, or fragment thereof.
Type:
Grant
Filed:
December 21, 2018
Date of Patent:
July 21, 2020
Assignee:
Gloriana Therapeutics, Inc.
Inventors:
Alan Gilbert, Kyle McElearney, Terrence Michael Dobrowsky, Rashmi Rohit Kshirsagar
Abstract: The present disclosure pertains to a mammalian cell culture genetically modified to express, and which expresses, a neublastin antibody polypeptide, or fragment thereof, in the culture, and to a neublastin antibody polypeptide, or fragment thereof, made by a mammalian cell culture genetically modified to express, and which expresses, the neublastin antibody polypeptide, or fragment thereof.
Type:
Grant
Filed:
December 21, 2018
Date of Patent:
June 2, 2020
Assignee:
Gloriana Therapeutics, Inc.
Inventors:
Alan Gilbert, Kyle McElearney, Terrence Michael Dobrowsky, Rashmi Rohit Kshirsagar
Abstract: Disclosed are methods of improving impaired proprioception, treating brachial plexus injuries, regenerating large and small nerve fibers, treating dorsal root nerve injuries, and improving sensory neural responses in a subject by administration of a neublastin polypeptide.
Type:
Grant
Filed:
February 27, 2007
Date of Patent:
June 25, 2019
Assignee:
GLORIANA THERAPEUTICS, INC.
Inventors:
Anthony Rossomando, Frank Porreca, Dinah Wen-Yee Sah