Abstract: Provided is a composition for the treatment and/or prevention of Alzheimer's disease having an improved therapeutic or prophylactic effect together with reduced side effects. This composition for the treatment and/or prevention of Alzheimer's disease contains at least one compound selected from the group consisting of glycerophosphocholine (G) and pharmaceutically acceptable salts thereof as a first active ingredient and at least one compound selected from the group consisting of herperidin (H), narirutin (N), and pharmaceutically acceptable salts thereof as a second active ingredient. This composition promotes remyelination, promotes the activity of ?-secretase, and also suppresses the expression of ?-secretase.

Abstract: Provided is a composition for the treatment and/or prevention of Alzheimer's disease having an improved therapeutic or prophylactic effect together with reduced side effects. This composition for the treatment and/or prevention of Alzheimer's disease contains at least one compound selected from the group consisting of glycerophosphocholine (G) and pharmaceutically acceptable salts thereof as a first active ingredient and at least one compound selected from the group consisting of herperidin (H), narirutin (N), and pharmaceutically acceptable salts thereof as a second active ingredient. This composition promotes remyelination, promotes the activity of ?-secretase, and also suppresses the expression of ?-secretase.