Patents Assigned to Glumetrics Inc.
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Publication number: 20140128694Abstract: Disclosed are embodiments that relate to the deployment of a glucose sensor comprising an optical fiber into a physiological fluid, wherein the optical fiber has disposed along a distal region thereof a chemical indicator system comprising a fluorophore and a glucose binding moiety immobilized within a hydrogel, wherein the components of the chemical indicator system are in a dry state before deployment. Also disclosed is a one-point in vivo calibration of the chemical indicator system based on an independently measured glucose concentration.Type: ApplicationFiled: November 6, 2013Publication date: May 8, 2014Applicant: Glumetrics, Inc.Inventors: Stuart L. Gallant, William H. Markle, Mano Goharla'ee
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Patent number: 8700115Abstract: Embodiments of the invention are directed to an optical sensor for detecting glucose. The sensor comprises a chemical indicator system disposed within a gap between the distal end of an optical fiber and an atraumatic tip portion, wherein the optical fiber and atraumatic tip portion are coupled by a coupling member, such as a rod or hypotube or cage that traverses the gap. The sensor further comprises a means for generating and detecting an optical reference signal unrelated to the glucose, such that ratiometric correction of glucose measurements for artifacts in the optical system is enabled.Type: GrantFiled: May 15, 2013Date of Patent: April 15, 2014Assignee: Glumetrics, Inc.Inventors: David R. Markle, Soya Gamsey, Thomas A. Peyser
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Publication number: 20140058225Abstract: Embodiments of the present invention are directed to an optical sensor capable of measuring two analytes simultaneously with a single indicator system. In preferred embodiments, the sensor comprises a fluorescent dye having acid and base forms that facilitate ratiometric pH sensing, wherein the dye is further associated with a glucose binding moiety and configured to generate a signal that varies in intensity with the concentration of glucose.Type: ApplicationFiled: July 25, 2013Publication date: February 27, 2014Applicant: GluMetrics, Inc.Inventors: David R. Markle, Jeff T. Suri, Ritchie A. Wessling, Matthew A. Romey
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Publication number: 20140058223Abstract: The present invention relates to a sensor for percutaneous insertion and intravascular residence without an indwelling cannula. In preferred embodiments, a glucose sensor is inserted into a blood vessel using a removable cannula. After the cannula is removed, the glucose sensor remains within the blood vessel by itself and forms a seal with the patient's tissue.Type: ApplicationFiled: August 19, 2013Publication date: February 27, 2014Applicant: Glumetrics, Inc.Inventors: David R. Markle, William H. Markle
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Patent number: 8658795Abstract: Novel pyridinium salts functionalized with boronic acid and methods of making them are disclosed. When combined with a fluorescent dye, the compounds are useful in the detection of polyhydroxyl-substituted organic molecules.Type: GrantFiled: April 25, 2012Date of Patent: February 25, 2014Assignee: Glumetrics, Inc.Inventors: Soya Gamsey, Ritchie A. Wessling
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Publication number: 20140018646Abstract: A method for achieving tight glycemic control in a patient in need thereof is disclosed. The method comprises deploying an equilibrium glucose sensor within a blood vessel in the patient, coupling the sensor to a monitor that displays the blood glucose concentration, and administering a blood glucose regulator when the blood glucose concentration varies outside of the predetermined concentration range. The blood glucose regulator is administered in an amount sufficient to return the blood glucose concentration to within the predetermined concentration range, thereby achieving tight glycemic control.Type: ApplicationFiled: September 11, 2013Publication date: January 16, 2014Applicant: Glumetrics, Inc.Inventors: William H. Markle, David R. Markle
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Patent number: 8535262Abstract: A method for achieving tight glycemic control in a patient in need thereof is disclosed. The method comprises deploying an equilibrium glucose sensor within a blood vessel in the patient, coupling the sensor to a monitor that displays the blood glucose concentration, and administering a blood glucose regulator when the blood glucose concentration varies outside of the predetermined concentration range. The blood glucose regulator is administered in an amount sufficient to return the blood glucose concentration to within the predetermined concentration range, thereby achieving tight glycemic control.Type: GrantFiled: December 9, 2011Date of Patent: September 17, 2013Assignee: Glumetrics, Inc.Inventors: William H. Markle, David R. Markle
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Patent number: 8512245Abstract: The present invention relates to a sensor for percutaneous insertion and intravascular residence without an indwelling cannula. In preferred embodiments, a glucose sensor is inserted into a blood vessel using a removable cannula. After the cannula is removed, the glucose sensor remains within the blood vessel by itself and forms a seal with the patient's tissue.Type: GrantFiled: April 16, 2009Date of Patent: August 20, 2013Assignee: Glumetrics, Inc.Inventors: David R. Markle, William H. Markle
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Patent number: 8498682Abstract: Embodiments of the present invention are directed to an optical sensor capable of measuring two analytes simultaneously with a single indicator system. In preferred embodiments, the sensor comprises a fluorescent dye having acid and base forms that facilitate ratiometric pH sensing, wherein the dye is further associated with a glucose binding moiety and configured to generate a signal that varies in intensity with the concentration of glucose.Type: GrantFiled: July 2, 2010Date of Patent: July 30, 2013Assignee: GluMetrics, Inc.Inventors: David R Markle, Jeff T Suri, Ritchie A Wessling, Matthew A Romey
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Patent number: 8473222Abstract: Disclosed herein are methods of estimating an analyte concentration which include generating a signal indicative of the analyte concentration, generating a signal indicative of a temperature, generating a signal indicative of a pH, and transforming the signal indicative of the analyte concentration utilizing an equation of the form of a modified Michaelis-Menten equation depending on Michaelis-Menten parameters, wherein values of the Michaelis-Menten parameters are set based upon data which includes temperature and pH calibration parameters, the signal indicative of a temperature, and the signal indicative of a pH. Also disclosed herein are measurement devices which employ the aforementioned methods.Type: GrantFiled: March 11, 2011Date of Patent: June 25, 2013Assignee: Glumetrics, Inc.Inventors: Matthew A. Romey, Soya Gamsey, Thomas A. Peyser
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Patent number: 8467843Abstract: Embodiments of the invention are directed to an optical sensor for detecting blood glucose. The sensor comprises a chemical indicator system disposed within a gap between the distal end of an optical fiber and an atraumatic tip portion, wherein the optical fiber and atraumatic tip portion are coupled by a coupling member, such as a rod or hypotube or cage that traverses the gap. The sensor further comprises a means for generating and detecting an optical reference signal unrelated to the blood glucose, such that ratiometric correction of blood glucose measurements for artifacts in the optical system is enabled.Type: GrantFiled: November 4, 2009Date of Patent: June 18, 2013Assignee: Glumetrics, Inc.Inventors: David R. Markle, Soya Gamsey, Thomas A. Peyser
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Patent number: 8202731Abstract: Novel fluorescent dyes are disclosed for use in analyte detection. In particular, mono- and bis-substituted HPTS dyes and methods of making them are provided.Type: GrantFiled: June 3, 2010Date of Patent: June 19, 2012Assignee: Glumetrics, Inc.Inventor: Jeff T. Suri
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Patent number: 8178676Abstract: Novel pyridinium salts functionalized with boronic acid and methods of making them are disclosed. When combined with a fluorescent dye, the compounds are useful in the detection of polyhydroxyl-substituted organic molecules.Type: GrantFiled: March 22, 2011Date of Patent: May 15, 2012Assignee: Glumetrics, Inc.Inventors: Soya Gamsey, Ritchie A. Wessling
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Patent number: 8110251Abstract: In preferred embodiments, the present invention relates to methods for polymerizing a monomer solution within a cavity covered by a porous membrane to generate a smooth polymer surface. More specifically, the method can be used to provide a medical device or sensor with a smooth polymer surface.Type: GrantFiled: February 5, 2008Date of Patent: February 7, 2012Assignee: Glumetrics, Inc.Inventors: David R. Markle, Huashi Zhang, Matthew A. Romey, Ritchie A. Wessling
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Patent number: 8088097Abstract: A method for achieving tight glycemic control in a patient in need thereof is disclosed. The method comprises deploying an equilibrium glucose sensor within a blood vessel in the patient, coupling the sensor to a monitor that displays the blood glucose concentration, and administering a blood glucose regulator when the blood glucose concentration varies outside of the predetermined concentration range. The blood glucose regulator is administered in an amount sufficient to return the blood glucose concentration to within the predetermined concentration range, thereby achieving tight glycemic control.Type: GrantFiled: November 20, 2008Date of Patent: January 3, 2012Assignee: Glumetrics, Inc.Inventors: William H. Markle, David R. Markle
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Patent number: 7939664Abstract: Novel pyridinium salts functionalized with boronic acid and methods of making them are disclosed. When combined with a fluorescent dye, the compounds are useful in the detection of polyhydroxyl-substituted organic molecules.Type: GrantFiled: May 1, 2008Date of Patent: May 10, 2011Assignee: Glumetrics Inc.Inventors: Soya Gamsey, Ritchie A. Wessling
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Publication number: 20110105866Abstract: Embodiments of the invention are directed to an optical sensor for detecting blood glucose. The sensor comprises a chemical indicator system disposed within a gap between the distal end of an optical fiber and an atraumatic tip portion, wherein the optical fiber and atraumatic tip portion are coupled by a coupling member, such as a rod or hypotube or cage that traverses the gap. The sensor further comprises a means for generating and detecting an optical reference signal unrelated to the blood glucose, such that ratiometric correction of blood glucose measurements for artifacts in the optical system is enabled.Type: ApplicationFiled: November 4, 2009Publication date: May 5, 2011Applicant: Glumetrics, Inc.Inventors: David R. Markle, Soya Gamsey, Thomas A. Peyser
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Publication number: 20110077477Abstract: Embodiments of the present invention relate to analyte sensors comprising a heparin benzalkonium antithrombogenic coating, and methods of coating analyte sensors.Type: ApplicationFiled: September 30, 2010Publication date: March 31, 2011Applicant: Glumetrics, Inc.Inventors: Matthew A. Romey, Soya Gamsey, David R. Markle
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Patent number: 7829341Abstract: The invention relates to a class of glucose-responsive, polyviologen boronic acid quenchers that may be used in combination with fluophores to achieve real-time measurement of glucose levels in vivo.Type: GrantFiled: July 11, 2008Date of Patent: November 9, 2010Assignee: Glumetrics, Inc.Inventors: Soya Gamsey, Ritchie A. Wessling
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Patent number: 7824918Abstract: Novel fluorescent dyes are disclosed for use in analyte detection. In particular, mono- and bis-substituted HPTS dyes and methods of making them are provided.Type: GrantFiled: August 6, 2008Date of Patent: November 2, 2010Assignee: Glumetrics, Inc.Inventor: Jeff T. Suri