Patents Assigned to GlycoDesign, Inc.
  • Novel core 2 beta-1,6-N-acetylglycosaminyltransferase gene
    Publication number: 20040053293
    Abstract: Novel core 2 &bgr;-1,6-N-acetylglycosaminyltransferase nucleic acids, polypeptides encoded by the nucleic acids, and uses of the nucleic acids and polypeptides.
    Type: Application
    Filed: May 12, 2003
    Publication date: March 18, 2004
    Applicant: GLYCODESIGN, INC.
    Inventors: Bozena Korczak, April Lew
  • Novel core 2 beta-1, 6-N-acetylglycosaminyltransferas E gene
    Publication number: 20040033521
    Abstract: The invention provides novel core 2 &bgr;-1,6-N-acetylglycosaminyltransferase nucleic acids, and polypeptides encoded by the nucleic acids. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists, and methods for treating disorders associated with the enzyme.
    Type: Application
    Filed: May 27, 2003
    Publication date: February 19, 2004
    Applicant: GLYCODESIGN, INC.
    Inventors: Bozena Korczak, April Lew
  • Novel 3,5,and/or 6 substituted analogues of swainsonine processes for their preparation and their use as therapeutic agents
    Publication number: 20030236229
    Abstract: The invention relates to novel 3, 5, and/or 6 swainsoninc analogues, processes for their preparation and their use as therapeutic agents. The invention also relates to pharmaceutical compositions containing the compounds and their use as therapeutics.
    Type: Application
    Filed: October 7, 2002
    Publication date: December 25, 2003
    Applicant: GlycoDesign Inc.
    Inventors: Rajan Shah, Jeremy Carver, Jose Marino-Albernas, Igor Tvaroska, Francois Daniel Tropper, James Dennis
  • Core 2 &bgr;-1,6-N-acetylglycosaminyltransferase gene
    Patent number: 6593119
    Abstract: Novel core 2 &bgr;-1,6-N-acetylglycosaminyltransferase nucleic acids, polypeptides encoded by the nucleic acids, and uses of the nucleic acids and polypeptides.
    Type: Grant
    Filed: February 28, 2001
    Date of Patent: July 15, 2003
    Assignee: Glycodesign, Inc.
    Inventors: Bozena Korczak, April Lew
  • Novel 3, 5, and/or 6 substituted analogues of swainsonine, processes for their preparation and their use as therapeutic agents
    Publication number: 20020099065
    Abstract: The invention related to novel 3, 5, and/or 6 swainsonine analogues, processes for their preparation and their use as therapeutic agents. The invention also relates to pharmaceutical compositions containing the compounds and their use as therapeutics.
    Type: Application
    Filed: October 29, 2001
    Publication date: July 25, 2002
    Applicant: GlycoDesign Inc.
    Inventors: Rajan Shah, Jeremy Carver, Jose Marino-Albernas, Igor Tvaroska, Francois Daniel Tropper, James Dennis
  • Alkaloid halide salts of swainsonine and methods of use
    Patent number: 6395745
    Abstract: Crystalline salts of swainsonine, and methods using same.
    Type: Grant
    Filed: March 27, 2000
    Date of Patent: May 28, 2002
    Assignee: GlycoDesign, Inc.
    Inventors: James W. Dennis, Rajan N. Shah, Lothar Ziser
  • Synthesis of swainsonine salts
    Patent number: 6051711
    Abstract: A method for synthesizing swainsonine salts and intermediates thereof comprising subjecting a compound of the formula I ##STR1## wherein R.sup.2 and R.sup.2' are the same or different and represent alkyl, halogen, alkenyl, alkoxy, cycloalkyl or aryl which may be substituted, to acid hydrolysis in the presence of a C.sub.1-4 alkanol to obtain a crystalline salt of swainsonine; and optionally, recrystallizing the swainsonine salt from a C.sub.1-4 alkanol. The reaction may be used in combination with one or more additional reaction steps.
    Type: Grant
    Filed: October 23, 1998
    Date of Patent: April 18, 2000
    Assignee: GLYCODesign Inc.
    Inventors: Francois Tropper, Rajan N. Shah, Pradeep Sharma
  • Derivatives of swainsonine and their use as therapeutic agents
    Patent number: 5962467
    Abstract: The invention relates to novel mannosidase inhibitors, processes for their preparation and their use as therapeutic agents.
    Type: Grant
    Filed: July 21, 1997
    Date of Patent: October 5, 1999
    Assignee: GlycoDesign, Inc.
    Inventors: Jeremy Carver, Rajan Shah
  • Mannosidase inhibitors, process for their preparation and their use as therapeutic agents
    Patent number: 5773239
    Abstract: The invention relates to novel mannosidase inhibitors, processes for their preparation and their use as therapeutic agents. The invention also relates to the use of compounds of the formula II as described herein as prodrugs.
    Type: Grant
    Filed: December 6, 1995
    Date of Patent: June 30, 1998
    Assignees: Mount Sinai Hospital Corporation., GlycoDesign, Inc.
    Inventors: Jeremy Carver, James Wilson Dennis, Rajan Shah
  • Derivatives of swainsonine, processes for their preparation and their use as therapeutic agents
    Patent number: 5650413
    Abstract: The invention relates to novel mannosidase inhibitors, processes for their preparation and their use as therapeutic agents. The invention also relates to pharmaceutical compositions containing the compounds and their use as therapeutics.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 22, 1997
    Assignee: Glycodesign Inc.
    Inventors: Jeremy Carver, Rajan Shah