Patents Assigned to GLYCODISPLAY APS
  • Lysosomal enzymes modified by cell based glycoengineering
    Patent number: 12325871
    Abstract: The present invention relates to lysosomal enzymes modified by use of cell based methods, a compositions comprising a modified lysosomal enzyme, as well as methods for producing a modified lysosomal enzyme and therapeutic use of such modified lysosomal enzyme. In particular, the present disclosure relates to a modified lysosomal enzyme which has low Man6P and low exposed Mannose and high sialic acid content of alpha2,3 type enabling long circulation time and improved uptake into difficult-to-reach organs like heart, kidney and brain.
    Type: Grant
    Filed: May 19, 2023
    Date of Patent: June 10, 2025
    Assignees: University of Copenhagen, GLYCODISPLAY APS
    Inventors: Claus Kristensen, Weihua Tian, Henrik Clausen, Zhang Yang, Sergey Vakhrushev
  • Modified recombinant lysosomal alpha-galactosidase A and aspartylglucoaminidase having low mannose-6-phosphate and high sialic acid
    Patent number: 11708569
    Abstract: The present invention relates to lysosomal enzymes modified by use of cell based methods, a compositions comprising a modified lysosomal enzyme, as well as methods for producing a modified lysosomal enzyme and therapeutic use of such modified lysosomal enzyme. In particular, the present disclosure relates to a modified lysosomal enzyme which has low Man6P and low exposed Mannose and high sialic acid content of alpha2,3 type enabling long circulation time and improved uptake into difficult-to-reach organs like heart, kidney and brain.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: July 25, 2023
    Assignees: University of Copenhagen, GLYCODISPLAY APS
    Inventors: Claus Kristensen, Weihua Tian, Henrik Clausen, Zhang Yang, Sergey Vakhrushev