Abstract: Sialic acid recognizing-affinity reagents engineered from the neuraminidase NanB have lectin-like properties and defined specificities for sialic acid.
Type:
Grant
Filed:
April 24, 2018
Date of Patent:
September 6, 2022
Assignees:
University of Georgia Research Foundation, Inc., Glycosensors and Diagnostics, LLC
Inventors:
Loretta Yang, Kausar N. Samli, Robert J. Woods, Shengcheng Wu, John C. Cooper, Mallory K. Paul, Matthew J. Saunders, Ziad M. Eletr
Abstract: The carbohydrate processing enzyme PNGase F was catalytically inactivated through mutation. Additional mutations yielded a catalytically inactive carbohydrate-binding protein with lectin-like properties including high affinity and specificity N-linked glycans, O-linked glycans, or both.
Type:
Grant
Filed:
April 17, 2015
Date of Patent:
July 23, 2019
Assignees:
University of Georgia Research Foundation, Inc., Glycosensors and Diagnostics, LLC
Inventors:
Kausar N. Samli, Robert J. Woods, Loretta Yang
Abstract: Provided are lectenz molecules, which are mutated carbohydrate processing enzymes that are catalytically inactive and that have had their substrate affinity increased by at least 1.2 fold. Further provided are methods for making and methods of using such lectenz. Additional mutated proteins following the lectenz approach are further provided.
Type:
Grant
Filed:
December 10, 2009
Date of Patent:
March 27, 2018
Assignees:
University of Georgia Research Foundation, Inc., Glycosensors and Diagnostics, LLC
Abstract: The carbohydrate processing enzyme PNGase F was catalytically inactivated through mutation. Additional mutations yielded a catalytically inactive carbohydrate-binding protein with lectin-like properties including high affinity and specificity N-linked glycans, O-linked glycans, or both.
Type:
Application
Filed:
April 17, 2015
Publication date:
July 6, 2017
Applicants:
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC., GLYCOSENSORS AND DIAGNOSTICS, LLC
Inventors:
Kausar N. Samli, Robert J. Woods, Loretta Yang
Abstract: The present invention relates to novel glycomimetic compounds that are rationally designed to inhibit the binding of various pathogens to cell surface sialylated galactose and methods of use thereof. Specifically sialic acid glycosides and C-glycosides are disclosed that form a lactam ring structure or a cyclic ether/amine ring structure with the adjacent monosaccharide residue.
Type:
Grant
Filed:
March 14, 2013
Date of Patent:
March 28, 2017
Assignees:
University of Georgia Research Foundation, Inc., National University of Ireland, Galway, Glycosensors and Diagnostics, LLC.
Inventors:
Robert J. Woods, Paul V. Murphy, Loretta Yang, Hannah M. K. Smith, Jenifer Hendel
Abstract: The present invention is includes compositions and methods directed to the multiplexed analysis of carbohydrates and carbohydrate containing compounds. The compositions and methods utilize suspension array technology (SAT) and an array of different carbohydrate binding molecules, each carbohydrate binding molecules with a known carbohydrate binding specificity, to obtain a glycoprofile of the carbohydrate structure(s) in a sample. Each carbohydrate binding molecule of a given specificity is linked to the external surface of a population of individually addressable particles.
Type:
Application
Filed:
March 1, 2012
Publication date:
January 2, 2014
Applicants:
GLYCOSENSORS AND DIAGNOSTICS, LLC., UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.