Patents Assigned to Glykos Finland Oy
  • HYDROPHILIC LINKERS AND CONJUGATES THEREOF
    Publication number: 20240000963
    Abstract: Hydrophilic linkers and their conjugates are disclosed.
    Type: Application
    Filed: September 18, 2023
    Publication date: January 4, 2024
    Applicant: GLYKOS FINLAND OY
    Inventors: Tero SATOMAA, Jari HELIN, Juhani SAARINEN
  • Hydrophilic linkers and conjugates thereof
    Patent number: 11793886
    Abstract: Hydrophilic linkers and their conjugates are disclosed.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: October 24, 2023
    Assignee: Glykos Finland Oy
    Inventors: Tero Satomaa, Jari Helin, Juhani Saarinen
  • Conjugates of a glycoprotein or a glycan with a toxic payload
    Patent number: 11723983
    Abstract: The invention relates to a glycoprotein-toxic pay-load molecule conjugate, a toxic payload molecule-glycan conjugate, and a pharmaceutical composi-tion. The invention further relates to a method for preparing the glycoprotein-toxic payload molecule conjugate, the method for modulating growth of a cell population and a method of treating tu-mour cells.
    Type: Grant
    Filed: March 23, 2021
    Date of Patent: August 15, 2023
    Assignee: GLYKOS FINLAND OY
    Inventors: Tero Satomaa, Jari Helin, Filip S. Ekholm
  • PROTEASE DEFICIENT FILAMENTOUS FUNGAL CELLS AND METHODS OF USE THEREOF
    Publication number: 20220290165
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Application
    Filed: November 18, 2021
    Publication date: September 15, 2022
    Applicant: GLYKOS FINLAND OY
    Inventors: Christopher LANDOWSKI, Anne HUUSKONEN, Juhani SAARINEN, Ann WESTERHOLM-PARVINEN, Anne KANERVA, Jari NATUNEN, Anna-Liisa HÄNNINEN, Noora SALOVUORI, Merja PENTTILÄ, Markku SALOHEIMO
  • O-Mannosyltransferase Deficient Filamentous Fungal Cells and Methods of Use Thereof
    Publication number: 20220213451
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins with reduced O-mannosylation in filamentous fungal cells, such as Trichoderma cells. More specifically, the invention provides a PMT-deficient filamentous fungal cell comprising a) at least a first mutation that reduces an endogenous protease activity compared to a parental filamentous fungal cell which does not have said first mutation, and, b) at least a second mutation in a PMT gene that reduces endogenous O-mannosyltransferase activity compared to a parental filamentous fungal cell which does not have said second mutation, wherein said filamentous fungal cell is selected from the group consisting of Trichoderma, Neurospora, Myceliophthora or Chrysosporium cell.
    Type: Application
    Filed: March 21, 2022
    Publication date: July 7, 2022
    Applicant: Glykos Finland OY
    Inventors: Jari Natunen, Jukka Hiltunen, Anne Huuskonen, Markku Saloheimo, Christian Ostermeier, Benjamin Patrick Sommer, Ramon Wahl
  • Protease deficient filamentous fungal cells and methods of use thereof
    Patent number: 11180767
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: November 23, 2021
    Assignee: GLYKOS FINLAND OY
    Inventors: Christopher Landowski, Anne Huuskonen, Juhani Saarinen, Ann Westerholm-Parvinen, Anne Kanerva, Jari Natunen, Anna-Liisa Hänninen, Noora Salovuori, Merja Penttilä, Markku Saloheimo
  • CONJUGATES OF A GLYCOPROTEIN OR A GLYCAN WITH A TOXIC PAYLOAD
    Publication number: 20210252158
    Abstract: The invention relates to a glycoprotein-toxic pay-load molecule conjugate, a toxic payload molecule-glycan conjugate, and a pharmaceutical compos-ition. The invention further relates to a method for preparing the glycoprotein-toxic payload molecule conjugate, the method for modulating growth of a cell population and a method of treating tu-mour cells.
    Type: Application
    Filed: March 23, 2021
    Publication date: August 19, 2021
    Applicant: GLYKOS FINLAND OY
    Inventors: Tero SATOMAA, Jari HELIN, Filip S. EKHOLM
  • PROTEASE DEFICIENT FILAMENTOUS FUNGAL CELLS AND METHODS OF USE THEREOF
    Publication number: 20210139922
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Application
    Filed: June 26, 2020
    Publication date: May 13, 2021
    Applicant: GLYKOS FINLAND OY
    Inventors: Christopher LANDOWSKI, Anne HUUSKONEN, Juhani SAARINEN, Ann WESTERHOLM-PARVINEN, Anne KANERVA, Jari NATUNEN, Anna-Liisa HÄNNINEN, Noora SALOVUORI, Merja PENTTILÄ, Markku SALOHEIMO
  • Multiple proteases deficient filamentous fungal cells and methods of use thereof
    Patent number: 10988791
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Grant
    Filed: July 20, 2020
    Date of Patent: April 27, 2021
    Assignee: GLYKOS FINLAND OY
    Inventors: Christopher Landowski, Anne Huuskonen, Ann Westerholm-Parvinen, Markku Saloheimo, Anne Kanerva, Jukka Hiltunen
  • Payload-Polymer-Protein Conjugates
    Publication number: 20210106692
    Abstract: The present invention relates to a conjugate represented by the formula [D-L-Y—(CH2)n-]mP-T wherein T is a protein; P is a polymer selected from the group consisting of dextran, mannan, pullulan, hyaluronic acid, hydroxyethyl starch, chondroitin sulphate, heparin, heparin sulphate, polyalkylene glycol, Ficoll, polyvinyl alcohol, amylose, amylopectin, chitosan, cyclodextrin, pectin and carrageenan, or a derivative thereof; m is at least 1; n is in the range of 1 to 10; each Y is independently selected from the group consisting of S, NH and 1,2,3-triazolyl, wherein 1,2,3-triazolyl is optionally substituted; each L is independently absent or comprises a linker group covalently joining D and Y; and each D is a payload molecule.
    Type: Application
    Filed: September 22, 2020
    Publication date: April 15, 2021
    Applicant: Glykos Finland Oy
    Inventors: Jari Helin, Juhani Saarinen, Filip S. Ekholm, Anne Leppanen
  • Saccharide Derivative of a Toxic Payload and Antibody Conjugates Thereof
    Publication number: 20210106689
    Abstract: A molecule comprising a saccharide bound via an O-glycosidic bond to a hydroxyl group of a toxic payload molecule is disclosed. An antibody-drug conjugate comprising an antibody covalently bound to a toxic payload molecule, optionally via a linker group, and a saccharide bound via an O-glycosidic bond to a hydroxyl group of the toxic payload molecule is further disclosed.
    Type: Application
    Filed: November 4, 2020
    Publication date: April 15, 2021
    Applicant: Glykos Finland Oy
    Inventors: Jari Helin, Juhani Saarinen, Tero Satomaa, Filip S. Ekholm
  • Saccharide derivative of a toxic payload and antibody conjugates thereof
    Patent number: 10973920
    Abstract: A molecule comprising a saccharide bound via an O-glycosidic bond to a hydroxyl group of a toxic payload molecule is disclosed. An antibody-drug conjugate comprising an antibody covalently bound to a toxic payload molecule, optionally via a linker group, and a saccharide bound via an O-glycosidic bond to a hydroxyl group of the toxic payload molecule is further disclosed.
    Type: Grant
    Filed: June 26, 2015
    Date of Patent: April 13, 2021
    Assignee: GLYKOS FINLAND OY
    Inventors: Jari Helin, Juhani Saarinen, Tero Satomaa, Filip S. Ekholm
  • Glycoprotein-toxic payload conjugates
    Patent number: 10973922
    Abstract: The invention relates to a glycoprotein-toxic payload molecule conjugate, a toxic payload molecule-glycan conjugate, and a pharmaceutical composition. The invention further relates to a method for preparing the glycoprotein-toxic payload molecule conjugate, the method for modulating growth of a cell population and a method of treating tumour cells.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: April 13, 2021
    Assignee: Glykos Finland OY
    Inventors: Tero Satomaa, Jari Helin, Filip S. Ekholm
  • O-Mannosyltransferase Deficient Filamentous Fungal Cells and Methods of Use Thereof
    Publication number: 20200362319
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins with reduced O-mannosylation in filamentous fungal cells, such as Trichoderma cells. More specifically, the invention provides a PMT-deficient filamentous fungal cell comprising a) at least a first mutation that reduces an endogenous protease activity compared to a parental filamentous fungal cell which does not have said first mutation, and, b) at least a second mutation in a PMT gene that reduces endogenous O-mannosyltransferase activity compared to a parental filamentous fungal cell which does not have said second mutation, wherein said filamentous fungal cell is selected from the group consisting of Trichoderma, Neurospora, Myceliophthora or Chrysosporium cell.
    Type: Application
    Filed: June 15, 2020
    Publication date: November 19, 2020
    Applicant: Glykos Finland OY
    Inventors: Jari Natunen, Jukka Hiltunen, Anne Huuskonen, Markku Saloheimo, Christian Ostermeier, Benjamin Patrick Sommer, Ramon Wahl
  • Multiple Proteases Deficient Filamentous Fungal Cells and Methods of Use Thereof
    Publication number: 20200347426
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Application
    Filed: July 20, 2020
    Publication date: November 5, 2020
    Applicant: GLYKOS FINLAND OY
    Inventors: Christopher Landowski, Anne Huuskonen, Ann Westerholm-Parvinen, Markku Saloheimo, Anne Kanerva, Jukka Hiltunen
  • HYDROPHILIC LINKERS AND CONJUGATES THEREOF
    Publication number: 20200323995
    Abstract: Hydrophilic linkers and their conjugates are disclosed.
    Type: Application
    Filed: June 20, 2018
    Publication date: October 15, 2020
    Applicant: GLYKOS FINLAND OY
    Inventors: Tero SATOMAA, Jari HELIN, Juhani SAARINEN
  • Protease deficient filamentous fungal cells and methods of use thereof
    Patent number: 10731168
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: August 4, 2020
    Assignee: GLYKOS FINLAND OY
    Inventors: Christopher Landowski, Anne Huuskonen, Juhani Saarinen, Ann Westerholm-Parvinen, Anne Kanerva, Jari Natunen, Anna-Liisa Hänninen, Noora Salovuori, Merja Penttilä, Markku Saloheimo
  • O-mannosyltransferase deficient filamentous fungal cells and methods of use thereof
    Patent number: 10724013
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins with reduced O-mannosylation in filamentous fungal cells, such as Trichoderma cells. More specifically, the invention provides a PMT-deficient filamentous fungal cell comprising a) at least a first mutation that reduces an endogenous protease activity compared to a parental filamentous fungal cell which does not have said first mutation, and, b) at least a second mutation in a PMT gene that reduces endogenous O-mannosyltransferase activity compared to a parental filamentous fungal cell which does not have said second mutation, wherein said filamentous fungal cell is selected from the group consisting of Trichoderma, Neurospora, Myceliophthora or Chrysosporium cell.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: July 28, 2020
    Assignee: GLYKOS FINLAND OY
    Inventors: Jari Natunen, Jukka Hiltunen, Anne Huuskonen, Markku Saloheimo, Christian Ostermeier, Benjamin Patrick Sommer, Ramon Wahl
  • Multiple proteases deficient filamentous fungal cells and methods of use thereof
    Patent number: 10724063
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: July 28, 2020
    Assignee: GLYKOS FINLAND OY
    Inventors: Christopher Landowski, Anne Huuskonen, Ann Westerholm-Parvinen, Markku Saloheimo, Anne Kanerva, Jukka Hiltunen
  • Multiple Proteases Deficient Filamentous Fungal Cells and Methods of Use Thereof
    Publication number: 20200087696
    Abstract: The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
    Type: Application
    Filed: November 22, 2019
    Publication date: March 19, 2020
    Applicant: GLYKOS FINLAND OY
    Inventors: Christopher Landowski, Anne Huuskonen, Ann Westerholm-Parvinen, Markku Saloheimo, Anne Kanerva, Jukka Hiltunen