Patents Assigned to GMP Endotherapeutics, Inc.
  • ASSAY FOR THE DETECTION OF FACTORS THAT MODULATE THE EXPRESSION OF INGAP
    Publication number: 20120058078
    Abstract: A reporter construct contains mammalian INGAP 5?-regulatory region or a fragment thereof, a minimal promoter element from mammalian INGAP or a heterologous promoter, and a reporter gene. The reporter construct can be used to screen for agents which alone or in combination up-regulate or down-regulate reporter gene expression. Alternatively, the reporter construct can be used to screen for agents that bind to the hamster INGAP 5?-regulatory region or a fragment thereof.
    Type: Application
    Filed: August 1, 2011
    Publication date: March 8, 2012
    Applicant: GMP Endotherapeutics, Inc.
    Inventors: David A. Taylor-Fishwick, Aaron I. Vinik
  • ASSAY FOR THE DETECTION OF FACTORS THAT MODULATE THE EXPRESSION OF INAGP
    Publication number: 20090156458
    Abstract: A reporter construct contains mammalian INGAP 5?-regulatory region or a fragment thereof, a minimal promoter element from mammalian INGAP or a heterologous promoter, and a reporter gene. The reporter construct can be used to screen for agents which alone or in combination up-regulate or down-regulate reporter gene expression. Alternatively, the reporter construct can be used to screen for agents that bind to the hamster INGAP 5?-regulatory region or a fragment thereof.
    Type: Application
    Filed: April 4, 2008
    Publication date: June 18, 2009
    Applicant: GMP ENDOTHERAPEUTICS, INC.
    Inventors: David A. Taylor-Fishwick, Aaron I. Vinik
  • INGAP displacement assays
    Patent number: 7442774
    Abstract: An antibody is provided which specifically recognizes and binds to INGAP protein. The antibody is used in competitive binding assays for quantitation of INGAP in biological samples. The assay can be performed on a solid support or in a suspension.
    Type: Grant
    Filed: October 6, 2005
    Date of Patent: October 28, 2008
    Assignee: GMP Endotherapeutics, Inc.
    Inventors: Aaron I. Vinik, David A. Taylor-Fishwick
  • Regulatory sequences for modulation of INGAP expression and reporter constructs
    Patent number: 7355024
    Abstract: A an isolated mammalian INGAP 5?-regulatory region comprising at least about nucleotides 1-3137 of SEQ ID NO: 2 (SEQ ID NO: 23).
    Type: Grant
    Filed: January 9, 2003
    Date of Patent: April 8, 2008
    Assignee: GMP Endotherapeutics, Inc.
    Inventors: David A. Taylor-Fishwick, Aaron I. Vinik
  • Assay for anti-INGAP antibodies
    Patent number: 7166439
    Abstract: A solid phase assay is used for detecting antibodies to INGAP104-118 peptide, a 15-amino acid peptide that is the biologically active portion of islet neogenesis associated protein (INGAP). The isotype of the antibodies to INGAP104-118 peptide can be determined. A kit can also be used in the detection of anti-INGAP104-118 antibodies. Endogenous autoantibodies or antibody production during therapeutic treatment of a mammal with INGAP104-118 can be monitored.
    Type: Grant
    Filed: February 27, 2003
    Date of Patent: January 23, 2007
    Assignee: GMP Endotherapeutics, Inc.
    Inventors: Aaron I. Vinik, David A. Taylor-Fishwick
  • INGAP displacement assays
    Patent number: 6986994
    Abstract: An antibody is provided which specifically recognizes and binds to INGAP protein. The antibody is used in competitive binding assays for quantitation of INGAP in biological samples. The assay can be performed on a solid support or in a suspension.
    Type: Grant
    Filed: January 7, 2002
    Date of Patent: January 17, 2006
    Assignee: GMP Endotherapeutics, Inc.
    Inventors: Aaron I. Vinik, David A. Taylor-Fishwick
  • Assay for anti-INGAP antibodies
    Publication number: 20030166031
    Abstract: A solid phase assay is used for detecting antibodies to INGAP104-118 peptide, a 15-amino acid peptide that is the biologically active portion of islet neogenesis associated protein (INGAP). The isotype of the antibodies to INGAP104-118 peptide can be determined. A kit can also be used in the detection of anti-INGAP104-118 antibodies. Endogenous autoantibodies or antibody production during therapeutic treatment of a mammal with INGAP104-118 can be monitored.
    Type: Application
    Filed: February 27, 2003
    Publication date: September 4, 2003
    Applicant: GMP Endotherapeutics, Inc.
    Inventors: Aaron I. Vinik, David A. Taylor-Fishwick
  • INGAP displacement assays
    Publication number: 20020127624
    Abstract: An antibody is provided which specifically recognizes and binds to INGAP protein. The antibody is used in competitive binding assays for quantitation of INGAP in biological samples. The assay can be performed on a solid support or in a suspension.
    Type: Application
    Filed: January 7, 2002
    Publication date: September 12, 2002
    Applicant: GMP Endotherapeutics, Inc.
    Inventors: Aaron I. Vinik, David A. Taylor-Fishwick