Abstract: The present invention relates to pharmaceutical compositions and methods for treating ischemic stroke in humans, using a tetrafluorobenzyl derivative of formula (I) or a pharmaceutically acceptable salt thereof conjointly with a thrombolytic drug, endovascular thrombectomy, or both (e.g., endovascular thrombectomy and a thrombolytic drug). Administration of a tetrafluorobenzyl derivative of formula (I) or its pharmaceutically acceptable salt can reduce reperfusion injury and other adverse events in patients conjointly receiving a thrombolytic drug, endovascular thrombectomy, or endovascular thrombectomy with a thrombolytic drug.
Type:
Grant
Filed:
March 10, 2021
Date of Patent:
November 28, 2023
Assignee:
GNT Pharma Co., Ltd.
Inventors:
Byoung Joo Gwag, Chun San An, Jing Yu Jin, Sung Ig Cho, Fangmeng Zhu, Xinliang Xu, Weiqiang Zhan, Fuxin Liu, Soon-Mi Won
Abstract: The present invention relates to a composition comprising: a 5-benzyl aminosalicylic acid compound in chemical formula I or cosmetically acceptable salts thereof; and a cosmetically acceptable excipient suitable for local administration. The composition comprising the 5-benzyl aminosalicylic acid compound in chemical formula I or cosmetically acceptable salts thereof can be used for reducing or alleviating human skin aging by means of antioxidant, anti-inflammatory and whitening actions on the skin.
Type:
Application
Filed:
July 8, 2020
Publication date:
August 11, 2022
Applicant:
GNT PHARMA CO., LTD.
Inventors:
Jin Hee SHIN, Byoung Joo GWAG, Soon Mi WON