Abstract: The use of permeation enhancers permits the formulation of transdermal dosage forms for calcium antagonists. These dosage forms are administrable to humans and other mammals, e.g., bovines.
Type:
Grant
Filed:
September 3, 1986
Date of Patent:
October 11, 1988
Assignee:
Godecke Akt.
Inventors:
Kurt H. Bauer, Dittmar Quade, Majid Mahjour
Abstract: A new catalytic process for the isomerization of asocainol isomers at the 6-position which provides an inexpensive, rapid, and simple method for large scale production of the (R,R) isomer of (R,S) asocainol is asocainol. The (R,R) isomer of (R,S) asocainol is treated with small amounts of a salt and an oxidizing agent at an elevated temperature. The compounds and their pharmaceutically acceptable salts are useful as potent antiarrhythmic agents and local anesthetics.