Abstract: The present invention concerns cyclic amino acids of formula ##STR1## substantially free from the lactam ##STR2## wherein n is an integer of from 4 to 6, a process for the preparation thereof, compositions containing the compounds and methods of using them.

Abstract: The instant invention is a tilidine salt, tilidine dihydrogen orthophosphate, which owing to its surprising stability, is particularly suitable for use in the preparation of solid, in particular delayed-action, drugs in tablet, pill or capsule form.

Abstract: New indolocarbazoles of formula: ##STR1## or a pharmaceutically acceptable salt thereof, processes for their preparation, compositions containing, and methods for using the composition for the inhibition of protein kinases, such as protein kinase C, for the prevention and/or treatment of heart and blood vessel diseases such as thromboses, arterioscleroses, hypertension, or for inflammatory processes, allergies, cancers, viral diseases, and certain degenerative damages of the central nervous system are disclosed.

Abstract: The invention concerns 2-aminocarboxylic acids and derivatives of formula ##STR1## processes for their preparation, as well as medicaments containing them for the inhibition of protein kinase C and thus for the prevention and/or treatment of heart and blood vessel diseases, such as thromboses, arterioscleroses, hypertension, of inflammatory processes, allergies, cancers, and certain degenerative damages of the central nervous system.

Abstract: The present invention provides a process for the preparation of tricyclo- [3.3.1.1.sup.3,7 ]dec-2-yl-[R-(R*,R*)]-3-(1H-indol-3-ylmethyl)-3-methyl-4,9-dioxo-7,11-diph enyl-10-oxa-2,5,8-triazaundecanate, an important compound in the preparation of a new class of cholecystokinin inhibitors, wherein N-[(benzyloxy)carbonyl]-(R)-.beta.-amino-1-azido-2-phenylethane is hydrogenated, and subsequently, by means of carbon dioxide, the resulting N.sup..beta. -[(benzyloxy)-carbonyl]-(R)-.beta.-amino-2-phenylethylamine carbonate is precipitated out. This is coupled by the carbodiimide process with N-[(2-adamantyloxy)-carbonyl]-.alpha.-methyl-R-tryptophane.

Abstract: The invention concerns new derivatives of certain alkoxy-4(1H)-pyridones, processes for preparing them, and pharmaceutical compositions containing them. The compounds of the invention are useful in the prevention and/or treatment of heart and blood vessel diseases such as thromboses, arteriosclerosis and hypertension, and of inflammatory processes, allergies, cancers, and certain degenerative damage of the central nervous system.

Abstract: The present invention provides a pharmaceutical composition containing 3,4-dihydro-1-phenyl-1-thio -1,2,4-benzothiadiazine 1-oxide useful for protecting lymphocytes.

Abstract: The instant invention concerns a novel process for the preparation of 1-aminomethyl-1-cyclohexaneacetic acid (gabapentin), a known compound useful for treating certain cerebral diseases such as epilepsy and dizziness.

Abstract: Processes for the preparation of cyclic amino acid derivatives useful in the treatment of cerebral diseases such as epilepsy are disclosed. Novel intermediates useful in processes are also disclosed.

Abstract: The present invention provides 9,10,11,12-tetrahydro-9,12-epoxy-1H-diindolo [1,2,3-fg: 3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione and 9,10,11,12-tetrahydro-2-(tetrahydro-5-methoxy-2-furanyl) -9,12-epoxy-1H-diindolo[1,2,3-fg: 3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione process for the preparation thereof, pharmaceutical compositions containing the compounds, and use of the compounds in heart and blood vessel diseases such as thromboses, arterioscleroses, hypertension and inflammatory diseases, allergies, cancer and certain degenerative damage of the central nervous system, as well as diseases of the immune system.

Abstract: N-phenylbenzamide derivatives of the general formula I ##STR1## wherein the radicals R.sup.1, R.sup.2, and R.sup.3, which can be the same or different, are a hydrogen atom or a methyl radical, as well as the pharmacologically acceptable salts thereof for controlling refractory tumors in mammals are described.

Abstract: A process for the preparation of an antacid material prepared from magnesium aluminum hydroxide, wherein magnesium hydroxide and/or magnesium oxide is reacted in an atomic ratio of magnesium to aluminum of 1:1 to 3:1 with an aqueous solution of aluminum sulfate until the pH of the reaction mixture is from 4.0 to 8.0, whereafter water-soluble components are removed from the mixture is known manner and this is isolated and, if desired, dried is described as well as a new embodiment of the formula [Mg.sub.5 Al.sub.10 (OH).sub.26 O.sub.5 ](SO.sub.4).sub.2 .multidot.nH.sub.2 O. Also described are pharmaceutical compositions containing such antacid material, in admixture with a conventional pharmaceutical adjuvant, and a method of combating hyperacidity and gastrointestinal diseases, which comprises administering such antacid material.

Abstract: N-phenylbenzamide derivatives of the general formula I ##STR1## wherein the radicals R.sup.1, R.sup.2, and R.sup.3, which can be the same or different, are a hydrogen atom or a methyl radical, as well as the pharmacologically acceptable salts thereof for controlling malignant, proliferative and auto-immune diseases and for immunosuppressive therapy upon grafting are described.

Abstract: 4-Alkoxy-pyrido[2,3-d]pyrimidine derivatives are described as well as processes for their preparation.For reason of their vasospasmolytic effects these compounds are mainly indicated for the treatment of cerebral, cardiac, and peripheral vascular diseases such as myocardiac ischemia, cerebral infarction, pulmonary thromboses, as well as in cases of arterioschlerosis and other stenotic disorders. They are therefore valuable agents for combating cardiovascular mortality.

Abstract: The present invention provides combination of materials for strengthening the antithrombotic action of acetylsalicylic acid. It covers a composition which contains diltiazem or a pharmaceutically acceptable acid-addition salt thereof in combination with acetylsalicylic acid. It also forms the new compound diltiazem acetysalicylate. It also covers compositions containing the above and methods for using the compositions or compound.

Abstract: The present invention provides a unique series of pyrido[4,3-b][1,6]naphthyridine derivatives. The compounds are calcium antagonists and are useful for blood vessel diseases. This invention also covers processes for preparing the compounds, pharmaceutical compositions containing them, and methods for using them.

Abstract: New 1,6-naphthyridinone derivatives of the formula I ##STR1## are herein described wherein R.sup.1 represents an unsubstituted or substituted aromatic or heteroaromatic ring;R.sup.2 is hydrogen, a straight-chained or branched alkyl, alkoxyalkyl, or a substituted or unsubstituted aminoalkyl group with up to ten carbon atoms;R.sup.3 is hydrogen, a straight-chained or branched alkyl group, or an alkoxycarbonyl radical with up to four carbon atoms;R.sup.4 is hydrogen, or a morpholinoethyl group;R.sup.5 is a straight-chained or branched alkyl group with up to four carbon atoms, or an amino group; andR.sup.6 is a carboxyl group, or an alkyl- or alkyloxyalkyl carbonyl radical, containing up to 12 carbon atoms and optionally interrupted by an oxygen, sulphur, or nitrogen atom;as well as optionally the pharmacologically acceptable salts thereof; processes for the preparation of these derivatives and their use in the control of vascular diseases.

Abstract: The invention concerns new 5-alkoxy-pyrido[4,3-d]pyrimidine derivatives and pharmacologically acceptable salts thereof, as well as a chemically novel process for their preparation. The new compounds are used in the control of cerebral, cardiac or peripheral vascular diseases or of stenotic symptoms.

Abstract: 4-Alkoxy-pyrido[2,3-d]pyrimidine derivatives are described as well as processes for their preparation.For reason of their vasospasmolytic effects these compounds are mainly indicated for the treatment of cerebral, cardiac, and peripheral vascular diseases such as myocardiac ischemia, cerebral infarction, pulmonary thromboses, as well as in cases of arteriosclerosis and other stenotic disorders. They are therefore valuable agents for combating cardiovascular mortality.

Abstract: The invention concerns new 5-oxo-pyrido[4,3-d]pyrimidine derivatives and the pharmacologically acceptable salts thereof, as well as a chemically novel process for the preparation of the new compounds and their use in the control of cerebral, cardiac, or peripheral vascular diseases or of stenotic symptoms.