Abstract: The disclosure relates to a method for determining a hydrodynamic size of an object, such as a nano-sized object, said method comprising the steps of: —providing a fluid interface, —linking said object to said fluid interface thereby providing a linked object, whereby the movement of said linked object is restricted by virtue of being linked to said fluid interface, —providing and determining a hydrodynamic shear force that acts on said linked object, —tracking the movement of said linked object, and —calculating the hydrodynamic size of the object using the Einstein-Smoluchowski relation.
Type:
Grant
Filed:
December 2, 2016
Date of Patent:
October 6, 2020
Assignee:
GOTHENBURG SENSOR DEVICES AB
Inventors:
Fredrik Höök, Stephan Block, Björn Johansson Fast, Anders Lundgren
Abstract: A waveguide structure for evanescent wave microscopy and/or spectroscopy, comprising an optically transparent core layer, a lower dielectric cladding layer and an upper dielectric cladding layer arranged on opposite sides of the core layer. The core layer has a refractive index higher than the refractive indices of the cladding layers. The upper cladding layer is made of an organic material. A sample well is arranged on an upper surface of the core layer formed by a cavity in the upper cladding layer, the sample well being adapted to contain a sample medium with one or more sample objects. The core layer is made of a first dielectric inorganic material, and the upper cladding layer has a refractive index which closely matches the refractive index of the sample medium. A method for manufacturing such waveguide structure, and a measurement system comprising the waveguide structure are also disclosed.
Type:
Grant
Filed:
June 26, 2014
Date of Patent:
March 28, 2017
Assignee:
GOTHENBURG SENSOR DEVICES AB
Inventors:
Fredrik Höök, Björn Agnarsson, Anders Lundgren, Anders Gunnarsson, Marta Bally, Lisa Simonsson Nyström
Abstract: A waveguide structure for evanescent wave microscopy and/or spectroscopy, comprising an optically transparent core layer, a lower dielectric cladding layer and an upper dielectric cladding layer arranged on opposite sides of the core layer. The core layer has a refractive index higher than the refractive indices of the cladding layers. The upper cladding layer is made of an organic material. A sample well is arranged on an upper surface of the core layer formed by a cavity in the upper cladding layer, the sample well being adapted to contain a sample medium with one or more sample objects. The core layer is made of a first dielectric inorganic material, and the upper cladding layer has a refractive index which closely matches the refractive index of the sample medium. A method for manufacturing such waveguide structure, and a measurement system comprising the waveguide structure are also disclosed.
Type:
Application
Filed:
June 26, 2014
Publication date:
June 2, 2016
Applicant:
GOTHENBURG SENSOR DEVICES AB
Inventors:
Fredrik Höök, Björn Agnarsson, Anders Lundgren, Anders Gunnarsson, Marta Bally, Lisa Simonsson