Abstract: A method for determining an optimized nucleotide sequence encoding a predetermined amino acid sequence, wherein the nucleotide sequence is optimized for expression in a host cell, and wherein the method comprises the steps of: (a) generating a plurality of candidate nucleotide sequences encoding the predetermined amino acid sequence; (b) obtaining a sequence score based on a scoring function based on a plurality of sequence features that influence protein expression in the host cell using a statistical machine learning algorithm, wherein the plurality of sequence features comprises one or more sequence features selected from the group consisting of protein per time, average elongation rate and accuracy for each of the plurality of candidate nucleotide sequences of step (a); and (c) determining the candidate nucleotide sequence with optimized protein expression in the host cell as the optimized nucleotide sequence.

Abstract: The invention relates to an ion mobility spectrometer which has at least a first drift chamber and a first switchable ion gate for the controlled transfer of ions into the first drift chamber, wherein:—the first ion gate is designed as a field switching ion gate having at least a first counter electrode and a first injection electrode; wherein—a first ionization chamber is formed between the first counter electrode and the first injection electrode, into which first ionization chamber ions to be analyzed by ion mobility spectrometry can be fed from an ionization source. The invention also relates to an ion mobility spectrometer which has at least a first drift chamber and a first switchable ion gate for the controlled transfer of ions into the first drift chamber and a second drift chamber separated from the first drift chamber and a second switchable ion gate for the controlled transfer of ions into the second drift chamber.

Abstract: The invention relates to an ion mobility spectrometer which has at least a first drift chamber and a first switchable ion gate for the controlled transfer of ions into the first drift chamber, wherein: —the first ion gate is designed as a field switching ion gate having at least a first counter electrode and a first injection electrode; wherein—a first ionization chamber is formed between the first counter electrode and the first injection electrode, into which first ionization chamber ions to be analyzed by ion mobility spectrometry can be fed from an ionization source. The invention also relates to an ion mobility spectrometer which has at least a first drift chamber and a first switchable ion gate for the controlled transfer of ions into the first drift chamber and a second drift chamber separated from the first drift chamber and a second switchable ion gate for the controlled transfer of ions into the second drift chamber.

Abstract: Method for encoding of quality values of a data structure, whereby said data structure comprises a set of genomic reads, wherein the method comprises the following steps executable by a data processing system: ascertain the quality values of each read covering a certain index locus, —determine a codebook identifier identifying a specific codebook from a plurality of codebooks for said certain index locus based on the ascertained quality values of said certain index locus, whereby each code-book provides a mapping from a quality value of said quality value alphabet to a corresponding quantized quality value of a quantized quality value alphabet, —quantizing all ascertained quality values at said certain index locus using the specific codebook identified by the codebook identifier at said certain index locus in order to obtain for each quality value at said certain index locus a corresponding quantized quality value, and —encode all determined codebook identifiers using a first entropy encoder and encode all qu

Abstract: The invention relates to a method for operating an ion gate having a first, a second, and a third electrode which are arranged one after the other in an intended drifting direction of ions to be influenced by the ion gate, in such a way that the second electrode is arranged after the first electrode and the third electrode is arranged after the second electrode in the drift direction. The ion gate can be switched between a closed state, in which ions cannot drift through the ion gate in the intended drifting direction, and an open state, in which ions can drift through the ion gate in the intended drifting direction. This is accomplished by applying potentials that alternate over time to one or more of the electrodes. In a switching cycle of the ion gate, which comprises the open state and the closed state of the ion gate, two different closed states of the ion gate are produced. In a first closed state, the ion gate is closed by applying a first potential between the second and third electrodes.

Abstract: The invention relates to an optical sensor system, which is designed to interact with a mobile computer device, which has at least one light source and at least one camera, wherein the sensor system has at least one incoupling interface for coupling light from the light source of the computer device into the sensor system and at least one outcoupling interface for coupling light from the sensor system out to the camera of the computer device, wherein the sensor system has at least one optical light-guiding path, by means of which the outcoupling interface is optically connected to the incoupling interface, wherein at least one sensor designed to modify the light guided by the light-guiding path according to a physical quantity influencing the sensor system from outside is arranged in the light-guiding path, wherein at least one sensor designed to modify the light guided by the light-guiding path according to an influencing quantity influencing the sensor system from outside is arranged in the light-guiding pa

Abstract: The present invention relates to the use of particular macrocycles that are inhibitors of the proteasomic degradation of p27, in particular argyrin and derivatives thereof, for a treatment in a variety of conditions, such as the induction of immunotolerance, autoimmune diseases, bacterial infections, and proliferative diseases, such as cancers.

Abstract: The invention relates to a parametric oscillator (1) for generating ultra-short pulses. The system (1) comprises a resonator (10) having an optical axis (11), an amplifier crystal (9) arranged in the resonator (10), and a pump laser system (4) for generating pump laser radiation (5) comprising pump photons, said pump laser radiation being directed onto the amplifier crystal (9). The invention is characterized in that the amplifier crystal (9) is an optically non-linear crystal configured for generating a signal photon and an idler photon from a pump photon by means of an optical-parametric process, wherein the resonator (10) is arranged in such a way that a signal pulse formed from the signal photons leaves the amplifier crystal (9) along the optical axis (11) of the resonator (10), and wherein dispersion compensation members for at least partially compensating the dispersion of the radiation circulating in the resonator (10) are provided.

Abstract: We present a method for predictive compression of time-consistent 3D mesh sequences supporting and exploiting scalability. The applied method decomposes each frame of a mesh sequence in layers, which provides a time-consistent multi-resolution representation. Following the predictive coding paradigm, local temporal and spatial dependencies between layers and frames are exploited for layer-wise compression. Prediction is performed vertex-wise from coarse to fine layers exploiting the motion of already encoded neighboring vertices for prediction of the current vertex location. Consequently, successive layer-wise decoding allows to reconstruct frames with increasing levels of detail.

Abstract: The invention relates to a parametric oscillator (1) for generating ultra-short pulses. The system (1) comprises a resonator (10) having an optical axis (11), an amplifier crystal (9) arranged in the resonator (10), and a pump laser system (4) for generating pump laser radiation (5) comprising pump photons, said pump laser radiation being directed onto the amplifier crystal (9). The invention is characterized in that the amplifier crystal (9) is an optically non-linear crystal configured for generating a signal photon and an idler photon from a pump photon by means of an optical-parametric process, wherein the resonator (10) is arranged in such a way that a signal pulse formed from the signal photons leaves the amplifier crystal (9) along the optical axis (11) of the resonator (10), and wherein dispersion compensation members for at least partially compensating the dispersion of the radiation circulating in the resonator (10) are provided.

Abstract: We present a method for predictive compression of time-consistent 3D mesh sequences supporting and exploiting scalability. The applied method decomposes each frame of a mesh sequence in layers, which provides a time-consistent multi-resolution representation. Following the predictive coding paradigm, local temporal and spatial dependencies between layers and frames are exploited for layer-wise compression. Prediction is performed vertex-wise from coarse to fine layers exploiting the motion of already encoded neighboring vertices for prediction of the current vertex location. Consequently, successive layer-wise decoding allows to reconstruct frames with increasing levels of detail.

Abstract: A method of concealing a packet loss during video decoding is provided. An input stream having a plurality of network abstraction layer units NAL is received. A loss of a network abstraction layer unit in a group of pictures in the input stream is detected. A valid network abstraction layer unit order from the available network abstraction layer units is outputted. The network abstraction layer unit order is received by a video coding layer (VCL) and data is outputted.