Patents Assigned to Government of The United States, d/b/a The Department of Veterans Affairs
  • Administration of a thiol-based chemoprotectant compound
    Publication number: 20060177523
    Abstract: A method of administration of a thiol-based chemoprotectant agent including NAC (N-acetylcysteine) and STS (sodium thiosulfate) that markedly affects biodistribution and protects against injury from diagnostic or therapeutic intra-arterial procedures. A method for treating or mitigating the side effects of cytotoxic cancer therapy for tumors located in the head or neck and brain tumors. The thiol-based chemoprotectant agent is administered intra-arterially with rapid and first pass uptake in organs and tissues other than the liver.
    Type: Application
    Filed: November 14, 2005
    Publication date: August 10, 2006
    Applicants: Oregon Health & Science University, Government of The United States, d/b/a The Department of Veterans Affairs
    Inventors: Edward Neuwelt, Leslie Muldoon, Michael Pagel