Patents Assigned to Government of the United States of America, as Represented by Secretary, Dept. of Human Services
  • MATERIALS AND METHODS FOR ABCB1 POLYMORPHIC VARIANT SCREENING, DIAGNOSIS, AND TREATMENT
    Publication number: 20090325156
    Abstract: The invention provides methods and materials for screening for polymorphic variants in ABCB1 and diagnosing altered susceptibilities for drug-induced heart rhythm irregularities based on the same. These methods allow better treatment regimens for using drugs that bind a protein encoded by the ABCB1 and/or induce heart rhythm irregularities such as the anti-cancer drug FK228.
    Type: Application
    Filed: November 9, 2006
    Publication date: December 31, 2009
    Applicant: Government of the United States of America, as Represented by Secretary, Dept. of Human Services
    Inventors: William D. Figg, Alexander Sparreboom, Tristan Sissung, Richard L. Piekarz, Susan E. Bates