Patents Assigned to Government of the United States of America, represented by Secretary, Departmemt of Health and
  • FITNESS ASSAY AND ASSOCIATED METHODS
    Publication number: 20080085918
    Abstract: The present invention provides an assay for determining the biochemical fitness of a biochemical species in a mutant replicating biological entity relative to its predecessor. The present invention further provides a continuous fluorogenic assay for measuring the anti-HIV protease activity of protease inhibitor. The present invention also provides a method of administering a therapeutic compound that reduces the chances of the emergence of drug resistance in therapy.
    Type: Application
    Filed: October 11, 2007
    Publication date: April 10, 2008
    Applicants: Government of the United States of America, represented by Secretary, Departmemt of Health and, Board of Trustees of the University of Illinois
    Inventors: John ERICKSON, Sergei GULNIK, Hiroaki MITSUYA, Arun GHOSH