Patents Assigned to GOVERNMENT OF THE UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY
  • Patent number: 12152242
    Abstract: Disclosed herein are methods for systemically editing a gene in a subject and for systemically treating a genetic condition in a subject using a dual-vector CRISPR-Cas therapy. The methods comprise administering to the subject, via systemic administration, a gene editing AAV vector encoding a CRISPR effector protein (e.g., a Cas protein) and a targeting AAV vector providing one or more gRNAs targeted to the gene. In the methods, the ratio of the targeting AAV vector to the gene editing vector is greater than or equal to 2. Also provided are dual-vector systems for editing a gene or treating a genetic disease in a subject.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: November 26, 2024
    Assignees: The Curators of the University of Missouri, The Government of the United States of America as Represented by the Secretary of the Department of Health and Human Services
    Inventors: Dongsheng Duan, Chady Hakim, Nalinda B. Wasala, Yongping Yue
  • Publication number: 20240386087
    Abstract: An access control system and method configured to DNA-based identification to verify user identification. The access control system may be configured to access a database of biometric and biographic data. The database may comprise a biometric and biographic dataset associated with users. Matching logic may determine whether a user attempting to gain access to a secured location or system matches a dataset. The access control system may comprise a microfluidics device configured to perform DNA fingerprinting. The access control system may also comprise a silicone processor configured to execute the matching logic.
    Type: Application
    Filed: May 15, 2024
    Publication date: November 21, 2024
    Applicant: The Government of the United States of America, as represented by the Secretary of Homeland Security
    Inventor: Mark Fry
  • Publication number: 20240383440
    Abstract: A method to authenticate operators of motor vehicles includes obtaining, based on a driver's license, operator information of an operator of a motor vehicle. The method further includes authenticating, by a Vehicle Identification and Secure Operating Program (VISOP) running on an onboard computer of the motor vehicle, the operator information with a Motor Vehicle Department (MVD). The method determines, based on the authenticating and vehicle identifying information pertaining to the motor vehicle, whether the operator is approved to operate the motor vehicle. The method performs biometric identification to verify that the driver's license matches the operator. The method prevents the motor vehicle from starting, responsive to the operator not being approved to operate the motor vehicle, and allows the motor vehicle to start, responsive to the operator being approved to operate the motor vehicle.
    Type: Application
    Filed: May 15, 2024
    Publication date: November 21, 2024
    Applicant: The Government of the United States of America, as represented by the Secretary of Homeland Security
    Inventor: Cuthbert Delmer Johnson
  • Publication number: 20240386086
    Abstract: An access control system and method configured to DNA-based identification to verify user identification. The access control system may be configured to access a database of biometric and biographic data. The database may comprise a biometric and biographic dataset associated with users. Matching logic may determine whether a user attempting to gain access to a secured location or system matches a dataset. The access control system may comprise a microfluidics device configured to perform DNA fingerprinting. The access control system may also comprise a silicone processor configured to execute the matching logic.
    Type: Application
    Filed: May 15, 2024
    Publication date: November 21, 2024
    Applicant: The Government of the United States of America, as represented by the Secretary of Homeland Security
    Inventor: Mark Fry
  • Patent number: 12147476
    Abstract: Systems and methods are provided for a hypergraph representation and transformation process enabling the cogeneration and analysis of multiple system attributes alongside system node relationships within real world data models. Embodiments of the present disclosure allow for the cogeneration of attribute embeddings, along with node embeddings, within a single, graph-based data set model. Embodiments of the present disclosure provide a higher level of accuracy in problem space representation compared to conventional systems and methods and help to reveal more complex relationships in real world problems.
    Type: Grant
    Filed: September 30, 2023
    Date of Patent: November 19, 2024
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Joseph Macker, Michael Iannelli
  • Patent number: 12149038
    Abstract: Methods for synthesizing fibers having nanoparticles therein are provided, as well as preforms and fibers incorporating nanoparticles. The nanoparticles may include one or more rare earth ions selected based on fluorescence at eye-safer wavelengths, surrounded by a low-phonon energy host. Nanoparticles that are not doped with rare earth ions may also be included as a co-dopant to help increase solubility of nanoparticles doped with rare earth ions in the silica matrix. The nanoparticles may be incorporated into a preform, which is then drawn to form fiber. The fibers may beneficially be incorporated into lasers and amplifiers that operate at eye safer wavelengths. Lasers and amplifiers incorporating the fibers may also beneficially exhibit reduced Stimulated Brillouin Scattering.
    Type: Grant
    Filed: June 22, 2021
    Date of Patent: November 19, 2024
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Colin C. Baker, Edward J. Friebele, Woohong Kim, L. Brandon Shaw, Jasbinder S. Sanghera
  • Patent number: 12138948
    Abstract: A substrate is printed with front side and back side markings. The front side when viewed with reflected light includes: a first marking printed with a first gradient of two colors; a second marking printed with a second gradient of two colors; a first symbol printed with a third gradient of two colors; a second symbol printed with a fourth gradient of two colors; a third symbol printed with a fifth gradient of two colors; and a fourth symbol printed with a sixth gradient of two colors. The back side when viewed with reflected light includes: a third marking printed with the fourth gradient; a fourth marking printed with the third gradient; a fifth symbol printed with the second gradient; a sixth symbol printed with the first gradient; a seventh symbol printed with the sixth gradient; and an eighth symbol printed with the fifth gradient.
    Type: Grant
    Filed: December 20, 2023
    Date of Patent: November 12, 2024
    Assignee: The Government of the United States of America, represented by the Secretary of Homeland Security
    Inventors: Joel Zlotnick, Jordan Brough, Troy Eberhardt, Tyra McConnell, Elizabeth Gil, Traci Moran
  • Patent number: 12142098
    Abstract: In examples, a relative skin reflectance of a captured image of a subject is quantified. Based on the relative skin reflectance, the captured image is determined as suitable or not suitable for biometric identification. When the captured image is determined not suitable, a remedial capture setting is calculated and provided to an image capturing resource. Another captured image of the subject, captured under the remedial capture setting, is received from the image capturing resource. The relative skin reflectance of the another captured image is quantified and based thereon, there is a determining of whether the another captured image is suitable or is not suitable.
    Type: Grant
    Filed: January 11, 2024
    Date of Patent: November 12, 2024
    Assignee: The Government of the United States of America, as represented by the Secretary of Homeland Security
    Inventors: Arun R. Vemury, Yevgeniy B. Sirotin, Cynthia M. Cook, John J. Howard, Jerry L. Tipton
  • Patent number: 12138904
    Abstract: A bonded optical assembly comprising infrared-transparent materials. The assembly comprises two or more infrared transparent optical elements and a polymer comprising at least one chalcogenide element and crosslinking moieties between the infrared-transparent optical elements. The crosslinking moieties may be organic, inorganic, or both.
    Type: Grant
    Filed: November 7, 2023
    Date of Patent: November 12, 2024
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Darryl A. Boyd, Jason D. Myers, Vinh Q. Nguyen, Daniel J. Gibson, Colin C. Baker, Woohong Kim, Jasbinder S. Sanghera
  • Patent number: 12143134
    Abstract: Methods and apparatuses for downconverting high frequency subbands to a lower frequency band and recovering signals-of-interest. The system includes a controller, a signal generator, an optical source, a dual-drive mach zehnder modulator (DDMZM), a photodetector, and a dechipping/image (DI) rejector. The controller outputs chipping frequencies to the signal generator which generates local oscillator (LO) tones shifted by the respective chipping frequencies. The optical source outputs an optical signal to the DDMZM which has first and second arms and modulators. The first modulator receives a signal from a source and modulates it onto the optical signal propagating through the first arm to form a first modulated optical signal. The second modulator receives the shifted local oscillator tones and modulates them onto the optical signal propagating through the second arm to form a second modulated optical signal.
    Type: Grant
    Filed: September 30, 2022
    Date of Patent: November 12, 2024
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Bryan Haas, Jason McKinney
  • Publication number: 20240367859
    Abstract: In an example, a bin prowl apparatus comprises a bin prowl including a distal end and a proximal end. The proximal end has a proximal width which is at least ten times larger than a distal width of the distal end. The proximal end is configured to be connected with a front wall of a bin. The proximal width of the proximal end is at least 30% of a bin width of the front wall of the bin. The distal end extends forward from the proximal end along a direction of a length of the bin and is spaced from the proximal end by a minimum distance of 10% to over 100% of the proximal width of the proximal end.
    Type: Application
    Filed: May 3, 2024
    Publication date: November 7, 2024
    Applicant: The Government of the United States of America, as represented by the Secretary of Homeland Security
    Inventors: John F. Jasinski, Lee J. Spanier
  • Publication number: 20240371145
    Abstract: A method that includes receiving a set of one or more images, each having one or more sets of pixels, receiving a ground truth value that a vertex point associated with a transition between two regions in a respective set of pixels, identifying a machine placement candidate vertex point for a first set of pixels, determining a set of one or more selected candidate features in the set of candidate features that maximizes an objective function that identifies an accuracy of the identified machine placement candidate vertex point compared to the respective ground truth for a respective set of pixels, updating a set of one or more basis features by adding the set of one or more selected candidate features that maximizes the objective function, and training a machine learning model based on the updated set of one or more basis features to identify additional vertex points for a transition.
    Type: Application
    Filed: May 6, 2024
    Publication date: November 7, 2024
    Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Steven M. DENNIS, Christopher J. MICHAEL
  • Patent number: 12123817
    Abstract: A device to determine density includes a housing, a first transducer disposed in the housing at a first position, and a second transducer disposed in the housing at a second position. The second transducer is located a distance from the first transducer. The device also includes a controller that reads a first output from the first transducer, and reads a second output from the second transducer. The controller determines a density of a liquid based on the first output, the second output, and the distance.
    Type: Grant
    Filed: August 15, 2023
    Date of Patent: October 22, 2024
    Assignee: The Government of the United States of America, as represented by the Secretary of Homeland Security
    Inventors: Jeffrey Barber, James C. Weatherall, Duane Karns, Barry T. Smith
  • Patent number: 12126740
    Abstract: Systems and methods for providing authentication and secure cryptographic communication between a client and server are described. The client includes an addressable array of PUF devices. The client receives or generates a set of instructions usable to determine a range of PUF addresses. The client measures the PUF addresses and generates a first set of responses. The responses are used to encrypt a session key, which is stored, along with the instructions and a hash of the responses, at the client. Later, the client may recover the session key by using the instructions to measure the PUF again, resulting in a second set of responses. Using a response-based cryptography search engine, the client may then iteratively modify and hash the second set of responses until a response set is uncovered that matches the first response set. This modified response set may then be used to uncover the session key.
    Type: Grant
    Filed: June 25, 2022
    Date of Patent: October 22, 2024
    Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF NORTHERN ARIZONA UNIVERSITY, GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE
    Inventors: Bertrand F. Cambou, Sareh Assiri, Christopher Robert Philabaum, H. Shelton Jacinto
  • Publication number: 20240344288
    Abstract: An apparatus includes a head having an obverse side and a reverse side. The apparatus includes a vertical load cell detachably connected to the obverse side. The vertical load cell in operation measures a plurality of vertical loads at a respective plurality of ground depths. The apparatus includes a plurality of pins connected to the reverse side. Each pin of the plurality of pins includes a rod and a cone connected to the rod. The apparatus includes a torsional load cell detachably connected to the obverse side. The torsional load cell in operation measures a plurality of torques at a respective plurality of rotational angles.
    Type: Application
    Filed: April 9, 2024
    Publication date: October 17, 2024
    Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Trina L. Merrick, Andrei Abelev, Michael S. Vermillion
  • Patent number: 12116519
    Abstract: This disclosure concerns a method of making a ligand for Quantum Dot functionalization, a method of making a functionalized Quantum Dot (QD) with a ligand, and a method of making a transparent luminescent quantum dot thiol-yne nanocomposite with tailorable optical, thermal, and mechanical properties. The prepolymer solution and functionalized Quantum Dot can be used in additive manufacturing.
    Type: Grant
    Filed: April 5, 2022
    Date of Patent: October 15, 2024
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Darryl A. Boyd, Michael H. Stewart, Kimihiro Susumu, Eunkeu Oh, James P. Wissman
  • Publication number: 20240339367
    Abstract: A method of making an erasable nanocellulose electronic structure comprising the steps of providing a nanocellulose sheet, adhering metal contacts onto the nanocellulose sheet, applying solder to the metal contacts, and attaching surface mount devices to the contacts. An erasable nanocellulose electronic structure comprising a nanocellulose sheet, a metal contact on the nanocellulose sheet, a layer of solder on the metal contact, and a surface mount device to the contact.
    Type: Application
    Filed: March 26, 2024
    Publication date: October 10, 2024
    Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Jonathan D. Yuen, Mona Ebrish
  • Patent number: 12110376
    Abstract: An article having: an elastomeric jacket; a gel within the jacket; and a plurality of gas-filled, polymerically-encapsulated microbubbles suspended in the gel. The microbubbles have a Gaussian particle size distribution. The largest microbubble has a diameter at least 10 times the diameter of the smallest microbubble. The article may exhibit Anderson localization at at least one frequency of sound waves impacting the article.
    Type: Grant
    Filed: January 25, 2022
    Date of Patent: October 8, 2024
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Bernard R. Matis, Nicholas T. Gangemi, Jeffrey W. Baldwin, Steven W. Liskey, Aaron D. Edmunds, William B. Wilson, Douglas M. Photiadis
  • Patent number: 12114569
    Abstract: Thermoelectric (TE) nanocomposite material that includes at least one component consisting of nanocrystals. A TE nanocomposite material in accordance with the present invention can include, but is not limited to, multiple nanocrystalline structures, nanocrystal networks or partial networks, or multi-component materials, with some components forming connected interpenetrating networks including nanocrystalline networks. The TE nanocomposite material can be in the form of a bulk solid having semiconductor nanocrystallites that form an electrically conductive network within the material.
    Type: Grant
    Filed: December 2, 2022
    Date of Patent: October 8, 2024
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Boris N. Feigelson, Kevin P. Anderson, Benjamin L Greenberg, James A. Wollmershauser, Alan G. Jacobs
  • Publication number: 20240330807
    Abstract: A resource allocation system may comprise a prediction engine configured to generate a prediction record in a database and a history module configured to store a service record for a service. The resource allocation system may comprise a comparison engine configured to compare the prediction against the service records. The resource allocation system may comprise a service improvement module configured to: use the prediction record and generate a recommendation for a settings change to the resource allocation system. The resource allocation system configured to implement a change to the service to improve performance of services based on the recommendation.
    Type: Application
    Filed: March 26, 2024
    Publication date: October 3, 2024
    Applicant: The Government of the United States of America, as represented by the Secretary of Homeland Security
    Inventor: William Hastings