Abstract: The present invention provides a method and compositions for specifically delivering an effector molecule to a tumor cell. The method involves providing a chimeric molecule that comprises an effector molecule attached to a targeting molecule that specifically binds an IL-13 receptor and contacting a tumor cell with the chimeric molecule.
Type:
Application
Filed:
December 13, 2002
Publication date:
July 10, 2003
Applicant:
The Government of the USA as represented by the Secretary of the Dept. of Health & Human Services
Inventors:
Raj K. Puri, Waldemar Debinski, Ira Pastan, Nicholas Obiri
Abstract: The invention provides methods for using local heat to control gene expression. The heat shock protein (hsp) gene promoter is recombined with a selected therapeutic gene and expressed in selected cells. Local controlled heating is used to activate the hsp promoter, for example by using focused ultrasound controlled by MRI.
Type:
Application
Filed:
March 11, 2002
Publication date:
November 7, 2002
Applicant:
The Government of the USA as represented by the Secretary of the Dept. of Health & Human Services
Abstract: An onboard power generation apparatus for a hoist conveyance includes a drive wheel carried by the conveyance. The drive wheel is positioned to engage the surface of a stationary structure adjacent the conveyance, such as a shaft guide, so that movement of the conveyance relative to the structure causes rotation of the drive wheel. A charging generator coupled to the drive wheel is operable to produce an electric current upon rotation of the drive wheel. A battery may be electrically connected to the generator so that the generator provides an electric current to recharge the battery. The drive wheel may be mounted for movement relative to the conveyance with biasing mechanism for resiliently biasing the drive wheel toward the surface of the adjacent structure.
Type:
Application
Filed:
April 16, 2002
Publication date:
October 31, 2002
Applicant:
The Government of USA as represented by the Secretary of the Dept. of Health & Human Services
Inventors:
Michael J. Beus, Carl Sunderman, Richard Rains