Abstract: Systems and methods that use “cloud” technologies to standardize and simplify transactions between the Federal government and entities that do business with it. The system may include cloud storage containing data files for account user data, grant reporting documentation and grant results/products; secure storage for user account/e-commerce data and USASPENDING archival data on the grant; and regulatory decision support tools for use among administrators, principal investigators, and program directors. The system may include a grant decision support engine for optimizing use of grant funds and a regulatory assistance engine for grant regulatory compliance, reporting, and approval requirements specific to Federal agencies.