Abstract: A personalized health formula system which combines genetic and metabolic data to generate personalized intervention plan, termed Genetic and Metabolic Data Associated Intervention (GMDAI), as well as a computer readable medium and device containing the same is disclosed. The GMDAI personalized health formula system includes a pathway decision module and a supplement intervention module. The pathway decision module can make a decision of increasing or decreasing one or more of the markers by weighing detected levels of these markers, and the supplement intervention module can recommend a personalized supplementation formula including the type and dosage of supplement.