Patents Assigned to GPC-Biotech Inc.
  • Methods and regents for identifying synthetic genetic elements
    Patent number: 6342356
    Abstract: The present invention relates to a selection method that allows fast recovery and identification of functional gene fragments which selectively inhibit growth, e.g., are cytostatic or cytotoxic, of particular cell-types, such as transformed cells. The strategy relies, in part, on the ability of small gene fragments to encode dominant-acting synthetic genetic elements (SGEs), e.g., molecules which interfere with the function of genes from which they are derived. SGEs which can be identified by the subject method include, but are not limited to, inhibitory antisense RNA molecules, ribozymes, nucleic acid decoys, and small peptides.
    Type: Grant
    Filed: March 10, 2000
    Date of Patent: January 29, 2002
    Assignee: GPC Biotech, Inc.
    Inventor: Jeno Gyuris
  • Assays and reagents for identifying anti-fungal agents, and uses related thereto
    Patent number: 6277564
    Abstract: The present invention relates to rapid, reliable and effective assays for screening and identifying pharmaceutically effective compounds that specifically inhibit the biological activity of fungal GTPase proteins, particularly GTPases involved in cell wall integrity, hyphael formation, and/or other cellular functions critical to pathogenesis. Another aspect of the present invention relates to novel Candida genes and gene products.
    Type: Grant
    Filed: April 23, 1997
    Date of Patent: August 21, 2001
    Assignee: GPC Biotech Inc.
    Inventors: Vivian Berlin, Veronique Damagnez, Susan E. Smith
  • Assays and reagents for identifying anti-fungal agents, and uses related thereto
    Patent number: 6271197
    Abstract: The present invention relates to rapid, reliable and effective assays for screening and identifying pharmaceutically effective compounds that specifically inhibit the biological activity of fungal GTPase proteins, particularly GTPases involved in cell wall integrity, hyphael formation, and/or other cellular functions critical to pathogenesis. Another aspect of the present invention relates to novel Candida genes and gene products.
    Type: Grant
    Filed: April 23, 1997
    Date of Patent: August 7, 2001
    Assignees: GPC-Biotech Inc., The Johns Hopkins University
    Inventors: Vivian Berlin, David E. Levin, Yoshikazu Ohya, Veronique Damagnez, Susan E. Smith