Abstract: The invention concerns a drive system, especially for a motor vehicle, with a multicylinder internal combustion engine, a device for shutting off at least some of the cylinders of the internal combustion engine, and a device for active reduction of rotational nonuniformities, acting in particular on a shaft, such as a drive shaft of the internal combustion engine, or a shaft that is coupled or which can be coupled to it, which is active at least for certain operating states during cylinder shutoff mode. A method of operating such a drive system is also disclosed.