Abstract: The present invention relates to compounds according to general formula (I) which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.
Type:
Application
Filed:
January 20, 2021
Publication date:
May 13, 2021
Applicant:
GRÜNETHAL GMBH
Inventors:
Florian JAKOB, Jo ALEN, Simon LUCAS, Tobias CRAAN, Ingo KONETZKI, Achim KLESS, Stefan SCHUNK, Paul RATCLIFFE, Sebastian WACHTEN, Simon CRUWYS
Abstract: Substituted sulfonamide compounds corresponding to formula I: processes for the preparation thereof, pharmaceutical compositions containing these compounds, and the use of such substituted sulfonamide compounds in pharmaceutical compositions for the treatment and/or inhibition of pain and other conditions at least partly mediated by the bradykinin 1 receptor.
Type:
Grant
Filed:
April 8, 2009
Date of Patent:
November 27, 2012
Assignee:
Gruenethal GmbH
Inventors:
Stefan Oberboersch, Melanie Reich, Stefan Schunk, Michael Franz-Martin Engels, Ruth Jostock, Tieno Germann, Jean De Vry, Klaus Schiene, Sabine Hees
Abstract: Sulfonylated tetrahydroazolopyrazine compounds corresponding to the formula I wherein R1, R2a, R2b, R3a, R3b, R4, R8, R9a, R9b, R10, R11, A, B, W1, W2 and W3 have the meanings defined herein, pharmaceutical compositions containing such compounds, a method for the preparation of such compounds, and the use of such compounds for treating or inhibiting various types of pain and/or other conditions mediated at least in part by the bradykinin 1 receptor (B1R).
Type:
Application
Filed:
March 4, 2010
Publication date:
September 16, 2010
Applicant:
Gruenethal GmbH
Inventors:
Beatrix MERLA, Stefan Oberboersch, Melanie Reich, Stefan Schunk, Ruth Jostock, Sabine Hees, Michael Engels, Tieno Germann, Edward Bijsterveld
Abstract: The invention relates to a system for the oral administration of a solid to dementia sufferers comprising at least two devices, in which each device comprises an optionally transparent hollow article with a liquid inlet end and a liquid outlet end, wherein a solid and a liquid-permeable, optionally displaceable retention means are arranged in the interior of the hollow article in such a manner that the retention means prevents the solid from escaping from the interior of the hollow article via the liquid inlet end.
Type:
Application
Filed:
June 7, 2005
Publication date:
December 18, 2008
Applicant:
GRUENETHAL GMBH
Inventors:
Heinrich Kugelmann, Johannes Bartholomaus, Eric-Paul Paques
Abstract: Method for the treatment of increased urinary urgency or urinary incontinence comprising administering (+)-tramadol, O-demethyltramadol, (+)-O-demethyltramadol, O-desmethyl-N-mono-desmethyltramadol, or (+)-O-desmethyl-N-mono-desmethyltramadol, as free bases and/or in the form of physiologically compatible salts, are disclosed.