Patents Assigned to Graffinity Pharmaceutical Design GmbH
  • Patent number: 6921514
    Abstract: The invention relates to a device for carrying out an almost simultaneous synthesis of a plurality of samples. The device is especially suitable for use in automated laboratory processes in the area of combinatorial chemistry. The aim of the invention is to provide a device of this type which enables the synthesis of a plurality of samples bonded to microbeads, said microbeads being provided in the cavities of a support plate. To this end, a plane support plate (1) is provided with a plurality of cavities (11) arranged regularly in an iterative grid. The cavities accommodate microbeads (12). A removable covering (2) is provided, said covering being provided with webs (21) which each cover at least one of a row of associated cavities (11) in such a way that a capillary gap (3) is formed between the microbeads (12) and the webs (21) and larger recesses (22) are left respectively between the adjacent webs (21). A dosed liquid dispenser (4) is allocated to each capillary gap (3).
    Type: Grant
    Filed: June 10, 1999
    Date of Patent: July 26, 2005
    Assignee: Graffinity Pharmaceutical Design GmbH
    Inventors: Dirk Vetter, Kristina Schmidt
  • Patent number: 6795192
    Abstract: The invention relates to an an SPR surface plasmon resonance spectroscopy sensor for parallel measurement of a plurality of samples, comprising a body (1a) having several SPR sensor areas (2) for guiding radiation in order to carry out SPR measurements and which are coated with a material which is suitable for SPR in such a way that each SPR sensor area (2) can be exclusively associated with a single sample. The radiation conducting body (1a) forms a unit with the SPR sensor areas (2), whereby the path of the rays guided by the SPR sensor areas (2) can also extend through the radiation conducting body (1a).
    Type: Grant
    Filed: August 19, 2002
    Date of Patent: September 21, 2004
    Assignee: Graffinity Pharmaceutical Design GmbH
    Inventors: Stefan Dickopf, Kristina Schmidt, Dirk Vetter
  • Patent number: 6752963
    Abstract: The invention relates to an SPR sensor array comprising a plurality of SPR sensor surface areas (120) arranged on a substrate (10, 20) in a two-dimensional matrix located in a plane to which the SPR sensor surface areas (120) are parallel and whereby radiation capable of exciting surface plasmons in the SPR sensor surface areas (120) under specific physical conditions can be guided through the substrate (10, 20) to be reflected from the SPR sensor surface areas, as well as separating means (110) for separating each SPR sensor surface area (120) from its neighboring SPR sensor surface area (120), wherein the separating means (110) and SPR sensor surface areas (120) are provided such that at least outside of surface plasmon resonance occurring in the SPR sensor surface areas (120) the radiation (40) guided through the substrate (10, 20) is reflected in the region of the separating means to a different degree than in the region of the SPR sensor surface areas (120) to create a contrast between the separating mea
    Type: Grant
    Filed: February 21, 2001
    Date of Patent: June 22, 2004
    Assignee: Graffinity Pharmaceutical Design GmbH
    Inventors: Stefan Dickopf, Kristina Schmidt, Dirk Vetter, Klaus Burkert
  • Patent number: 6441906
    Abstract: The invention relates to a set-up of measuring instruments for the parallel readout of SPR sensors. The aim of the invention is to provide a measuring arrangement for the parallel readout of a plurality of SPR sensors, wherein the readout process should be terminated within an integration period of less than 30 minutes. To this end, a wavelength-selective component (5) and an optical imaging system (L2, L3) are arranged downstream of a light source (3).
    Type: Grant
    Filed: May 18, 2001
    Date of Patent: August 27, 2002
    Assignee: Graffinity Pharmaceutical Design GmbH
    Inventors: Stefan Dickopf, Kristina Schmidt, Dirk Vetter
  • Patent number: 6373577
    Abstract: The invention relates to a surface plasmon resonance sensor for the simultaneous measurement of a plurality of samples present in fluid form. The aim of the invention is to provide such a sensor which can be arranged into a defined array and where the surface plasmon resonance sensors can be produced using technology which is simpler and more economical than those produced according to the prior art. To this end several strip-like optical wave guides (2) are arranged on a planar support (1) at a defined distance to each other in such a way that their front faces (21, 22) are flush with opposite sides (11, 12) of the planar support (1). Each strip-like optical wave guide (2) in a section which is to be brought into contact with the fluid samples has at least one thin metal layer (3) which permits the excitation of surface plasmons.
    Type: Grant
    Filed: July 20, 2000
    Date of Patent: April 16, 2002
    Assignees: Graffinity Pharmaceutical Design GmbH, Fraunhofer Gesellschaft zur Foerderung der angewandten Forschung e.V.
    Inventors: Andreas Bräuer, Norbert Danz, Kristina Schmidt, Dirk Vetter, Ralf Waldhausl
  • Publication number: 20010002984
    Abstract: The invention relates to a reactor support comprising a plurality of micro sample accommodating chambers which is especially used in automated laboratory operations in the field of combinatorial chemistry. The aim of the invention is to provide such a reactor support which enables individual sample accommodating chambers to be loaded with sample particles in a simple manner, and above all which permits a simultaneous reproducible liquid filling of all sample accommodating chambers or of a part of the sample accommodating chambers, said part being selectable in a defined manner, without additional pipetting steps. To this end, recesses are provided in a plate. A shaped body is fitted into each recess. Said shaped body is provided with a recess which is open on one side and which is provided for accommodating a plurality of sample particles.
    Type: Application
    Filed: December 11, 2000
    Publication date: June 7, 2001
    Applicant: Graffinity Pharmaceutical Design GmbH
    Inventor: Dirk Vetter