Abstract: Apparatus for performing binder-substrate processing of clinical substances is disclosed. An operating head is provided which includes an array of upwardly opening receptacles each having a closed bottom. A temperature control element is located in the operating head proximate the receptacles. The operating head also includes a manifold having an influx chamber, an efflux chamber and a plurality of hollow prongs emanating from the influx chamber and through the efflux chamber. The prongs extend downwardly into respective of the receptacles to provide fluid communication between the influx chamber and the interior of the receptacles through the prongs. The efflux chamber is in fluid communication with the open ends of the receptacles to drain fluid therefrom. A solid phase binder is located in the bottoms of the respective receptacles, and may be coated on solid phase elements located in the receptacles or on the receptacles themselves.