Abstract: The present invention comprises methods and compositions for immunotherapy. An aspect of the invention comprises administration of one or more allergens in compositions via oral and sublingual routes. Allergen compositions are administered in dosing intervals wherein the increase in the one or more allergens administered to the patient are provided in increasing volumes of a single concentration of at least one allergen.

Abstract: A system, a method, and an apparatus are described herein for determining skin test sensitivities. A first skin test to evaluate a patient's skin reaction to one or more allergens may he performed. After measurements are taken of any reactions to the first skin test, a second skin test may be performed based on the results of the first skin test. Based on the results of the second test, an appropriate treatment endpoint for the patient may be determined. A computer-implemented method may be used for determining skin test sensitivities that may guide a user through one or more appropriate test selection and treatment endpoint determinations.

Abstract: The present invention comprises methods and compositions for immunotherapy. An aspect of the invention comprises administration of one or more allergens in compositions via oral and sublingual routes. Allergen compositions are administered in dosing intervals wherein the increase in the one or more allergens administered to the patient are provided in increasing volumes of a single concentration of at least one allergen.

Abstract: The present invention comprises methods and compositions for immunotherapy. An aspect of the invention comprises administration of one or more allergens in compositions via oral and sublingual routes. Allergen compositions are administered in dosing intervals wherein the increase in the one or more allergens administered to the patient are provided in increasing volumes of a single concentration of at least one allergen.

Abstract: There is provided an autoloader apparatus and skin testing system for rapidly loading a multi-headed applicator used for epicutaneous application of biological testing agents, while at the same time, effectively inhibiting cross contamination of testing agents during loading and removal of the applicator. The autoloader apparatus includes a plurality of reservoirs for storing testing agents therein. Each reservoir includes a collar defining an open top. The autoloader apparatus further includes a receptacle having first and second surfaces defining a plurality of apertures therethrough for at least partially receiving the collars of the reservoirs. The skin testing system includes an applicator and an autoloader. The applicator has a plurality of picks for sealably engaging the open tops of the reservoirs of the autoloader to enable each pick to be loaded with an effective amount of testing agent.

Abstract: There is provided an autoloader apparatus and skin testing system for rapidly loading a multi-headed applicator used for epicutaneous application of biological testing agents, while at the same time, effectively inhibiting cross contamination of testing agents during loading and removal of the applicator. The autoloader apparatus includes a plurality of reservoirs for storing testing agents therein. Each reservoir includes a collar defining an open top. The autoloader apparatus further includes a receptacle having first and second surfaces defining a plurality of apertures therethrough for at least partially receiving the collars of the reservoirs. The skin testing system includes an applicator and an autoloader. The applicator has a plurality of picks for sealably engaging the open tops of the reservoirs of the autoloader to enable each pick to be loaded with an effective amount of testing agent.

Abstract: A skin test applicator has a applicator handle (21) and separately storable test elements (13). A complimentary snap-fit attachment structure (33, 43) is provided on the applicator handle and test elements to permit the applicator handle to operatively pick up and hold one or more test elements from a suitable sterile storage tray. The skin test applicator reduces storage requirements and the amount of refuse that must be discarded immediately following the administration of a skin test for the diagnosis of an allergic response or other diagnostic test.

Abstract: There is provided a method for performing skin tests for biologic response which includes providing an applicator having at least one pick having at least one skin piercing epidermal point and being capable of carrying a load of testing substance such as biologic substances, such as an antigen, for skin testing for each pick, each of said sources being carried in a container having an opening. The applicator is placed in sealing relationship over each of the openings in the container to form a single unit of the combined applicator and source. The unit is then inverted so as to load each pick with an effective amount of substance to perform a skin test, reverting said unit, and the applicator is removed in loaded condition ready for use. The testing substances are epicutaneously deposited by piercing the patient's skin with each pick to a predetermined depth and observing the pierced skin for response to the testing substance.