Abstract: The invention relates to a measuring arrangement for optically evaluating a chemical reaction quantitatively, comprising a sample carrier having a carrier layer and a sample layer having an analysis side and a light outlet side opposite the analysis side, and comprising a photosensitive sensor having a plurality of photodetectors on a carrying body and having a transparent surface layer arranged over the photodetectors. A plurality of test sections are arranged on the analysis side at a distance from each other in a longitudinal direction of the sample layer. The analysis side is arranged on the carrier layer in such a way that the test sections face a volume of a microfluidic system. The sample carrier is detachably arranged in an accommodating device, so that the light outlet side faces the photosensitive sensor and the test sections are arranged over the photodetectors. Furthermore, the distance between the test sections and the photodetectors is less than 700 ?m.

Abstract: The application relates to a collection assembly (1), in particular for blood samples, comprising a sample container (2) and a closure device (3) which has a closure cap (22) and a pierceable septum (26) held on the closure cap. At its open end (4) delimited by an end face (11), the sample container has a flange (13) and an annular skirt (15), the flange projecting radially beyond a side wall (7). The annular skirt (15) extends axially from a flange end (14) to a closed end (5) of the sample container (2). The sample container (2), the flange (13) and the annular skirt form a one-piece component. Between an outer surface (9) of the side wall (7) and an inner annular skirt surface (16) facing toward this outer surface, there is an approximately tubular free space (17) which is delimited in the axial direction in the region of the open end (4) by the flange (13).

Abstract: The invention relates to a medical removal unit (1) for blood, comprising a needle carrier (2), at least one cannula (3), which has a distal and a proximal cannula segment (6, 7), and a hose-shaped sleeve (4), which has a closed sleeve end (12) and an open sleeve end (11). The sleeve (4) is fastened to a proximal needle-carrier end (10) by means of the open sleeve end (11) and surrounds the proximal cannula segment (7) in a sealing manner in such a way that an accommodating chamber (13) is formed. An air removal device (14) connects the accommodating chamber (13) to the outer environment in order that air flows out of the accommodating chamber and is formed by at least one outflow channel (15) arranged or formed in the needle carrier (2).

Abstract: The invention relates to a receptacle device (1) for separating a mixture (2) into a lighter phase (3) and a heavier phase (4), which comprises a receptacle (5) having an open end (7) and an end (8) closed by a base (9), and the open end (7) is closed by a removable closure unit (15). A separating element (14) made of an elastically deformable material is arranged in a receptacle chamber (13), and the separating element (14) in its non-deformed initial state has a spherical shape and is arranged in the region of the base (9) and contacts an internal face (11) of a side wall (10) in a contact plane (23) oriented perpendicular to a longitudinal axis (6). An external diameter (24) of the separating element (14) is selected to be larger in the non-deformed initial state thereof than a cross-sectional dimension (25) of the receptacle chamber (13) in the contact plane (23). The separating element (14) is held positioned on the internal face (11) of the side wall (10) in a pre-tensioned standby position.

Abstract: The invention relates to a method of filling nozzles (11) of a dispensing system (2) of a test system (1) comprising a dispensing system (2) and a microfluidic device (3) comprising at least the following steps: (a) transporting the solution from the container (6) via the nozzle (11) of the dispensing system (2) to the sample application opening (13) of the microfluidic device (3) by means of a micro-pump (10), (b) further transporting the solution into the measuring region of the microfluidic passage (14) of the microfluidic device (3), (c) measuring a light signal in the measuring region of the microfluidic device (3) by means of at least one photosensitive sensor (4) with a plurality of photodetectors (5), and (d) deactivating the micro-pump (10) when the light signal and/or a change in the light signal is detected.

Abstract: The invention relates to a safety assembly for medical technology, which comprises a handling device having a main part and a holding attachment and a longitudinal axis extending between a distal and a proximal end. A protective device is moreover provided, having a base part and a protective element connected pivotally thereto, wherein the base part is retained on the holding attachment of the handling device so as to rotate about the longitudinal axis. A locking device having first and second detent elements defines a relative position of the protective device with respect to the handling device. The at least first detent element provided on the handling device is arranged spaced from the holding attachment in the radial direction with respect thereto and spaced from the annular base part on the side facing away from the longitudinal axis.

Abstract: A microarray slide comprises a flat platform having a plurality of compartments thereon, the compartments having a bottom and a sidewall extending from the bottom. The platform and compartments are formed of a polymer material, such as polystyrene or cycloolefin, or other plastic material. The sidewall has a low profile such that the ratio of the surface area of the bottom to the height of the sidewall is greater than 30. In another aspect of the invention, the top surface of the slide is coated with a layer of reflective material such as aluminum, gold, chromium or other suitable reflective material. The layer of reflective material may be coated with a layer of protective coating, to prevent corrosion or other damage to the reflective layer and to functionalize the surface.

Abstract: A method for at least partially separating viral and/or prokaryotic nucleic acids from eukaryotic nucleic acids from a biological sample includes re-suspending the cells in the presence of a chelating agent, lysis of the cells by chemical lysis, and/or mechanical lysis, neutralizing the cell lysate and separating the precipitated eukaryotic nucleic acids and obtaining the viral and/or prokaryotic nucleic acids. A kit includes a re-suspension buffer with chelating agent and optionally a saccharide and RNAse, lysis buffer including at least one base and a detergent and neutralizing buffer for at least partially separating viral and/or prokaryotic nucleic acids from eukaryotic nucleic acids from a biological sample. The acid constant of the weak anion defines the pH value and kosmotropic property of the salt (cation+anion) in conjunction with the detergent, which determines the protein solubility and precipitation.

Abstract: The invention relates to a sampling method for performing sampling in an unmistakeable manner with execution on a data processing system having a data memory, wherein the data memory stores a plurality of sample-related and analysis-related data records and wherein the analysis-related data records are relationally linked to the sample-related data records, and wherein a user interface having an input/output apparatus is present which is communicatively connected to the data processing system. In this case, an order data record is produced from a captured first identification marker, particularly an identifier, from a first person and the subset of analysis-related data records and is stored in the data memory. Following performance of the sampling, an identification marker from a sampling container and a second identification marker from a second person are captured and an identifier which is read from the respective identification marker is stored in the order data record.

Abstract: The invention relates to a carrier comprising at least one substrate, which has a coating in at least certain regions produced from individual modules by plasma polymerization, and the coating has one or more free spaces in at least certain regions for accommodating at least one solution containing a biological sample.

Abstract: The present invention relates to an improved microplate which is constructed of at least one frame part and at least one bottom part, where the bottom part has a maximum thickness of 500 ?m.

Abstract: The invention relates to a measuring arrangement for optically evaluating a chemical reaction quantitatively, comprising a sample carrier having a carrier layer and a sample layer having an analysis side and a light outlet side opposite the analysis side, and comprising a photosensitive sensor having a plurality of photodetectors on a carrying body and having a transparent surface layer arranged over the photodetectors. A plurality of test sections are arranged on the analysis side at a distance from each other in a longitudinal direction of the sample layer. The analysis side is arranged on the carrier layer in such a way that the test sections face a volume of a microfluidic system. The sample carrier is detachably arranged in an accommodating device, so that the light outlet side faces the photosensitive sensor and the test sections are arranged over the photodetectors. Furthermore, the distance between the test sections and the photodetectors is less than 700 ?m.

Abstract: A process for the production of a reaction chamber assembly, wherein a flat substrate and bottomless reaction chambers are provided, the substrate is first loaded with a biological agent and then the bottomless reaction chambers are bonded glue-free to the substrate, in particular through laser bonding, and liquid-tight reaction chambers, for instance individual wells, individually connected wells, such as strips, or wells in the form of a microtiter plate, are obtained. The present invention further provides a kit comprising a substrate suitable for being loaded with at least one biological agent and at least one bottomless reaction chamber, wherein the kit is suitable for glue-free bonding of the bottomless reaction chamber to the substrate.

Abstract: The present invention relates to an improved microplate which is constructed of at least one frame part and at least one bottom part, where the bottom part has a maximum thickness of 500 ?m.

Abstract: The invention relates to a method of assembling a cap (20) of a closure device (9) with an open end (6, 7) of a housing container (5) for forming a container system (1) for body fluids, tissue parts or tissue cultures, whereby a relative rotating or pivoting movement is effected between the cap (20) and the housing container (5) about a common longitudinal axis (14). In order to generate the relative movement, a pressing force (F) is applied to at least one of the components to be assembled directed more or less in the direction of the longitudinal axis (14). The invention further relates to a cap (20) for forming the closure device (9), a housing container (5) and a container system (1) obtained as a result, comprising at least the cap (20), a sealing device (21) device retained in it and the housing container (5).

Abstract: The invention relates to oligonucleotides, which are suited as primers for amplifying DNA of genital human papilloma viruses (HPV), to oligonucleotides, which are suited for use as probes for typifying genital HPV genotypes, to methods for amplifying the DNA of genital human papilloma viruses (HPV), to methods for detecting and/or identifying genital HPV genotypes, to nucleotide microarrays containing the oligonucleotides, to kits and to the use of the oligonucleotides for amplifying or typifying genital HPV genotypes, for the diagnosis and/or early diagnosis of diseases and for producing agents for diagnosing diseases.

Abstract: The invention relates to a method for at least partially separating viral and/or prokaryotic nucleic acids from eukaryotic nucleic acids from a biological sample, in particular a eukaryotic cell suspension, comprising the following steps in the following order: a) re-suspending the cells in the presence of a chelating agent, in particular EDTA or EDTA in combination with a saccharide, b) lysis of the cells by chemical lysis, such as alkaline lysis, enzymatic lysis and/or boiling lysis and/or mechanical lysis, c) neutralizing the cell lysate and d) separating the precipitated eukaryotic nucleic acids and obtaining the viral and/or prokaryotic nucleic acids, as well as the use of a kit comprising a re-suspension buffer with chelating agent and optionally a saccharide and RNAse, lysis buffer comprising at least one base and a detergent and neutralizing buffer for at least partially separating viral and/or prokaryotic nucleic acids from eukaryotic nucleic acids from a biological sample, in particular a eukaryotic

Abstract: The present invention relates to a sample container for analyses suitable for medical diagnostics comprising a platform plate having at least one reaction chamber. The reaction chamber has a bottom and a sidewall which form a three-dimensional chamber which is open in the upward direction. The ratio of the numerical value of the surface area of the bottom is relatively large relative to the height of the sidewall. The ratio may be greater than or equal to 30, 35, 40, 45, 50, 60, 70, 80, or 90. The reaction chamber further comprises a binding area on an internal surface of the reaction chamber which may be functionalized for binding at least one chemical entity for use in an assay.

Abstract: The invention relates to a bioreactor (1) for cell and tissue culture for the mechanical stimulation and for perfusion of tissue or cell cultures, comprising an upper part (3) and a lower part (4) which is connected to said upper part (4) and which comprises a tissue culture chamber (8), wherein at least one distributor plate (12) is arranged in the tissue culture chamber (8), and a method for cultivating cells and tissues in the bioreactor (1).

Abstract: The invention relates to a method of collecting saliva from the oral cavity for detecting a test substance, comprising the steps of (a) cleaning the oral cavity, (b) stimulating saliva secretion with a saliva-collecting solution, (c) removing the saliva-saliva collecting solution mixture from the oral cavity and collecting it in a container (1), (d) transferring the saliva-saliva collecting solution mixture into a sealable collection vessel.