Patents Assigned to Grifols, S.A.
  • Patent number: 12163512
    Abstract: A method is for calibrating a peristaltic pump, and for dispensing a quantity of liquid by a peristaltic pump. A device for producing sterile preparations can execute the methods.
    Type: Grant
    Filed: March 17, 2020
    Date of Patent: December 10, 2024
    Assignee: GRIFOLS, S.A.
    Inventors: Carles Xavier Bellonch Orenes, David Rodriguez Jurado, Ceferino Ruz Torres, Ignacio Blazquez Garcia-Valenzuela, Xavier Fernandez Perez
  • Patent number: 11905060
    Abstract: Method for the aseptic filling of a bag with a pharmaceutical product or liquid which comprises the following steps: a) a first step in which the cap is inserted in the inlet of the bag; b) a second step in which said cap is raised and the pharmaceutical product or liquid concerned is introduced; c) a third step in which the cap is re-inserted in the inlet of the bag; and d) a fourth step in which the cap and the inlet of the bag are welded.
    Type: Grant
    Filed: March 3, 2020
    Date of Patent: February 20, 2024
    Assignee: GRIFOLS, S.A.
    Inventors: Jordi Boira Bonhora, Miquel Faba Vilella, Daniel Fleta Coit
  • Patent number: 11827403
    Abstract: Method for the aseptic filling of a bag with a pharmaceutical product or liquid which comprises the following steps: a) a first step in which the cap is inserted in the inlet of the bag; b) a second step in which said cap is raised and the pharmaceutical product or liquid concerned is introduced; c) a third step in which the cap is re-inserted in the inlet of the bag; and d) a fourth step in which the cap and the inlet of the bag are welded.
    Type: Grant
    Filed: March 3, 2020
    Date of Patent: November 28, 2023
    Assignee: GRIFOLS, S.A.
    Inventors: Jordi Boira Bonhora, Miquel Faba Vilella, Daniel Fleta Coit
  • Patent number: 11458070
    Abstract: A container for a solution of human plasma proteins has a primary inner bag made up of a first multilayer polymer film with two outer layers of polyethylene (PE) and an intermediate layer of ethylene vinyl alcohol (EVOH) copolymer, and a secondary outer bag made up of a second multilayer film with layers of polyethylene terephthalate (PET)-silicon oxides (SiOx), oriented polyamide (OPA), polypropylene (PP)-silicon oxides (SiOx) and polypropylene (PP), referred to as multilayer PP-SiOx.
    Type: Grant
    Filed: March 10, 2020
    Date of Patent: October 4, 2022
    Assignee: GRIFOLS, S.A.
    Inventors: Carlos Roura Fernandez, Jose Antonio Garcia Garcia, Estela Llorens Masas, Nuria Marzo Adam
  • Patent number: 11116765
    Abstract: Methods of treatment of NTM lung infections using formulations of liposomal ciprofloxacin. Specific liposome formulations and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations used in connection with such are described.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: September 14, 2021
    Assignee: GRIFOLS, S.A.
    Inventors: Igor Gonda, James Blanchard, David C. Cipolla, Luiz Eduardo Moreira Bermudez
  • Patent number: 11026941
    Abstract: A concentrated inhalable formulation of an antibiotic drug such as ciprofloxacin is disclosed. The antibiotic is formulated with sodium acetate and liposome which incorporate antibiotic. The formulation is aerosolized and inhaled for treatment of respiratory tract infections and other medical conditions.
    Type: Grant
    Filed: August 14, 2019
    Date of Patent: June 8, 2021
    Assignee: GRIFOLS, S.A.
    Inventors: David C. Cipolla, James Blanchard
  • Publication number: 20200323845
    Abstract: Methods of treatment of NTM lung infections using formulations of liposoma ciprofloxacin. Specific liposome formulations and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations used in connection with such are described.
    Type: Application
    Filed: June 26, 2020
    Publication date: October 15, 2020
    Applicant: GRIFOLS, S.A.
    Inventors: Igor Gonda, James Blanchard, David C. Cipolla, Luiz Eduardo Moreira Bermudez
  • Publication number: 20200309110
    Abstract: A method is for calibrating a peristaltic pump, and for dispensing a quantity of liquid by a peristaltic pump. A device for producing sterile preparations that can execute the methods.
    Type: Application
    Filed: March 17, 2020
    Publication date: October 1, 2020
    Applicant: GRIFOLS, S.A.
    Inventors: Carles Xavier BELLONCH ORENES, David RODRIGUEZ JURADO, Ceferino RUZ TORRES, Ignacio BLAZQUEZ GARCIA-VALENZUELA, Xavier FERNANDEZ PEREZ
  • Publication number: 20200297722
    Abstract: An aerosolizable formulation comprised of a drug, a carrier and pH affecting component is disclosed. The Drug is dissolved in the formulation at a concentration above which it remains in solution at neutral pH. This increases the concentration of the drug in solution making it possible to administer larger amounts of drug with the same or a smaller volume of formulation. When the formulation is aerosolized to small particles and inhaled into human lungs in small volumes (e.g. 0.05 to 0.5 mL) the fluids in the lungs neutralize the formulation causing the drug to participate out of solution. This results in the drug being delivered at a controlled rate below the rate at which drug is administered from a formulation initially at a neutral pH.
    Type: Application
    Filed: June 8, 2020
    Publication date: September 24, 2020
    Applicant: GRIFOLS, S.A.
    Inventors: David C. Cipolla, Igor Gonda
  • Publication number: 20200198820
    Abstract: Method for the aseptic filling of a bag with a pharmaceutical product or liquid which comprises the following steps: a) a first step in which the cap is inserted in the inlet of the bag; b) a second step in which said cap is raised and the pharmaceutical product or liquid concerned is introduced; c) a third step in which the cap is re-inserted in the inlet of the bag; and d) a fourth step in which the cap and the inlet of the bag are welded.
    Type: Application
    Filed: March 3, 2020
    Publication date: June 25, 2020
    Applicant: GRIFOLS, S.A.
    Inventors: Jordi BOIRA BONHORA, Miquel FABA VILELLA, Daniel FLETA COIT
  • Publication number: 20200198821
    Abstract: Method for the aseptic filling of a bag with a pharmaceutical product or liquid which comprises the following steps: a) a first step in which the cap is inserted in the inlet of the bag; b) a second step in which said cap is raised and the pharmaceutical product or liquid concerned is introduced; c) a third step in which the cap is re-inserted in the inlet of the bag; and d) a fourth step in which the cap and the inlet of the bag are welded.
    Type: Application
    Filed: March 3, 2020
    Publication date: June 25, 2020
    Applicant: GRIFOLS, S.A.
    Inventors: Jordi BOIRA BONHORA, Miquel FABA VILELLA, Daniel FLETA COIT
  • Patent number: 10625894
    Abstract: Method for the aseptic filling of a bag with a pharmaceutical product or liquid which comprises the following steps: a) a first step in which the cap is inserted in the inlet of the bag; b) a second step in which said cap is raised and the pharmaceutical product or liquid concerned is introduced; c) a third step in which the cap is re-inserted in the inlet of the bag; and d) a fourth step in which the cap and the inlet of the bag are welded.
    Type: Grant
    Filed: October 21, 2015
    Date of Patent: April 21, 2020
    Assignee: GRIFOLS, S.A.
    Inventors: Jordi Boira Bonhora, Miquel Faba Vilella, Daniel Fleta Coit
  • Patent number: 10624924
    Abstract: A method and device for treating cholesterol disorders includes administering at least one treatment regime including two or more rounds of plasmapheresis to a patient having abnormal total cholesterol, abnormal LDL levels and/or abnormal HDL levels prior to treatment. Treatment according to the method results in decreased LDL levels in patients having abnormal LDL levels and increased HDL levels in patients having abnormal HDL levels. Each subsequent round of plasmapheresis is conducted weekly, but no more than twice per week.
    Type: Grant
    Filed: March 12, 2012
    Date of Patent: April 21, 2020
    Assignee: GRIFOLS, S.A.
    Inventors: Victor Grifols Lucas, Victor Grifols Roura
  • Patent number: 10624814
    Abstract: A container for a solution of human plasma proteins has a primary inner bag made up of a first multilayer polymer film with two outer layers of polyethylene (PE) and an intermediate layer of ethylene vinyl alcohol (EVOH) copolymer, and a secondary outer bag made up of a second multilayer film with layers of polyethylene terephthalate (PET)-silicon oxides (SiOx), oriented polyamide (OPA), polypropylene (PP)-silicon oxides (SiOx) and polypropylene (PP), referred to as multilayer PP-SiOx.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: April 21, 2020
    Assignee: GRIFOLS, S.A.
    Inventors: Carlos Roura Fernandez, Jose Antonio Garcia Garcia, Estela Llorens Masas, Nuria Marzo Adam
  • Patent number: 10358462
    Abstract: The present invention relates to a method for the preparation of a solution of immunoglobulins based on an initial solution of immunoglobulins with a purity greater than or equal to 96% in the presence of a polyether or polymer of glycol, characterized in that it comprises the steps of: a) adding caprylic acid or salts of the same to the initial solution; b) adjusting the pH of the solution obtained in step a); c) incubating the solution obtained in step b) for the time and at a temperature necessary for the inactivation of enveloped viruses; d) performing a step of ultrafiltration/diafiltration on the solution obtained in step c).
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: July 23, 2019
    Assignee: INSTITUTO GRIFOLS, S.A.
    Inventors: Pere Ristol Debart, Salvador Grancha Gamon, Juan Ignacio Jorquera Nieto, Maria Mercedes Faro Tomas, Nuria Jorba Grifols
  • Patent number: 10350274
    Abstract: A method prepares a solution of human albumin by reducing dissolved oxygen in a solution of albumin until a concentration of oxygen equal to or less than 0.5 ppm is achieved. A solution of human albumin having a redox state closer to the redox state of the albumin present in human plasma can be achieved.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: July 16, 2019
    Assignee: GRIFOLS, S.A.
    Inventors: Juan Ignacio Jorquera Nieto, Ana Maria Ortiz Fernandez, Montserrat Costa Rierola
  • Patent number: 10336988
    Abstract: A method of purification of non-enveloped or pseudo-enveloped virus produced in vitro uses a composition with at least one detergent. A method of purification can use multiple detergents, and a method of determining the presence and/or level of a non-enveloped or pseudo-enveloped virus in a sample includes treating with at least one detergent.
    Type: Grant
    Filed: July 19, 2016
    Date of Patent: July 2, 2019
    Assignee: GRIFOLS, S.A.
    Inventors: Brett Buno, Terri Journigan, Joann Hotta, Michael Burdick
  • Patent number: 10208291
    Abstract: Polybrene as an additive in cell culture medium is used in methods for the generation of high-titer hepatitis E virus stocks and assays for titration of hepatitis E virus. A cell culture medium containing polybrene is used for high-titer HEV generation, a method for determining the presence and/or the level of HEV in a sample, and an HEV titration assay using polybrene.
    Type: Grant
    Filed: July 19, 2016
    Date of Patent: February 19, 2019
    Assignee: GRIFOLS, S.A.
    Inventors: Brett Buno, Terri Journigan, Joann Hotta, Michael Burdick
  • Patent number: 10121102
    Abstract: An RFID tag is for arrangement on a bottle for blood-derived products. The bottle includes a main body, the upper end of which includes a neck. The bottle is hermetically sealed by a cap arranged in the upper portion of the neck. The upper portion of the cap includes at least two through-pipes and at least two stiffening ribs that are each connected to the pipes by one of the respective ends thereof. The RFID tag has at least two openings shaped to fit each of the through-pipes, respectively, of the cap such that said RFID tag is positioned on the upper surface of the cap and thus overcomes the obstacle of the through-pipes and the respective stiffening ribs.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: November 6, 2018
    Assignee: GRIFOLS, S.A.
    Inventors: Carlos Roura Fernandez, Victor Grifols Roura, Jordi Boira Bonhora
  • Patent number: 10107806
    Abstract: The apparatus has a containing body with a flat upper functional floor for containing receptacles of reagents, diluents and samples, as well as housings for gel cards and incubators for the same; a lower floor containing receptacles for washing liquids and the collection of waste and cards and for housing the fluid control and electronic control system; a series of longitudinal and transverse guides associated with the upper part of the apparatus, suitable for carrying in suspension the moving heads of the apparatus, the heads being movable on the transverse guides; two heads, respectively for perforation and pipetting and for the transport of gel cards; two centrifuges and a gel card reader; and a folding touch screen providing information and control.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: October 23, 2018
    Assignee: GRIFOLS, S.A.
    Inventors: Enrique Martinell Gispert-Sauch, Jordi Puig Cebria