Patents Assigned to Grifols, S.A.
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Publication number: 20160304583Abstract: Described herein are methods for purifying recombinant, cell culture derived alpha1-protease inhibitor and removing a colored species that co-purifies with the recA1PI protein. Also described are methods for reducing the iron in cell culture derived alpha1-protease inhibitor.Type: ApplicationFiled: April 26, 2016Publication date: October 20, 2016Applicant: Grifols, S.A.Inventors: David OWNBY, Thomas P. Zimmerman, Jennifer A. Hunt, Charles Miller, Senthil Ranganathan, Tonny Dessources
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Patent number: 9441893Abstract: Described herein are devices and methods for thawing frozen biological products efficiently without harming the products.Type: GrantFiled: March 14, 2013Date of Patent: September 13, 2016Assignee: Grifols, S.A.Inventors: Ajoy Velayudhan, Robert Large
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Patent number: 9353165Abstract: Described herein are methods for purifying recombinant, cell culture derived alpha1-protease inhibitor and removing a colored species that co-purifies with the recA1PI protein. Also described are methods for reducing the iron in cell culture derived alpha1-protease inhibitor.Type: GrantFiled: March 14, 2013Date of Patent: May 31, 2016Assignee: Grifols, S.A.Inventors: David Ownby, Thomas P. Zimmerman, Jennifer A. Hunt, Charles Miller, Senthil Ranganathan, Tonny Dessources
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Patent number: 9205134Abstract: The present invention relates to the use of alpha-1-antitrypsin for the preparation of effective drugs for the treatment of chronic fatigue syndrome. In addition, the present invention relates to the use of plasma or other therapeutic forms with an alpha-1-antitrypsin content sufficient to obtain a dose of 6 mg or more of alpha-1-antitrypsin per kg of body weight at a frequency of between 1 and 31 days.Type: GrantFiled: June 24, 2010Date of Patent: December 8, 2015Assignee: Grifols, S.A.Inventors: Ana Garcia Quintana, José Alegre Martin
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Patent number: 9028465Abstract: Devices, systems, and methods for delivery of therapeutics, in particular thrombolytic agents, in particular plasmin, are provided. The devices, systems, and methods also provide for occlusion of a vessel or graft distal and/or proximal to a treatment zone. Also provided are devices, systems, and methods that trap emboli.Type: GrantFiled: April 9, 2013Date of Patent: May 12, 2015Assignee: Grifols, S.A.Inventors: Dean Chamberlain, Valery Novokhatny, David Fineberg
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Patent number: 9023797Abstract: Described herein are methods for inactivating viruses using caprylate in solutions containing albumin.Type: GrantFiled: July 25, 2013Date of Patent: May 5, 2015Assignee: Grifols, S.A.Inventors: Wytold Lebing, Doug Burns, Nathan Roth, Joann Hotta
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Patent number: 9016145Abstract: Device for taking samples of liquid from a collection container, characterized in that it comprises a support for liquid sample collection containers; a support for a set of containers into which the sample of liquid will be deposited; a support for connection elements; a container handling mechanism; and a device for inserting the containers into which the sample of liquid will be deposited into the connection element.Type: GrantFiled: January 19, 2010Date of Patent: April 28, 2015Assignee: Grifols, S.A.Inventors: Diego Lopez Alvarez, Sergi Roura Adell, Francisco Rodriguez Garcia, Oriol Causi Casamor, Shinji Wada
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Patent number: 8835175Abstract: A culture medium for human mesenchymal stem cells (hMSC) includes a mesenchymal stem cell basal medium; human leucocyte/platelet coat lysate; insulin; sodium selenite; ethanolamine; and basic fibroblast growth factor. This culture medium is effective for growing hMSC lines, including those which do not grow in culture medium normally used for this type of cell.Type: GrantFiled: March 15, 2013Date of Patent: September 16, 2014Assignee: Grifols, S.A.Inventors: Jose Maria Diez Cervantes, Rodrigo Gajardo Rodriguez
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Patent number: 8802385Abstract: The present invention relates to a new suspension medium or diluent solution for red blood cells for use in haematological methods. The suspension medium or diluent solution for red blood cells may comprise a combination of two or more amino acids of any group, and preserves the red blood cells in the sample for at least 8 weeks.Type: GrantFiled: June 22, 2007Date of Patent: August 12, 2014Assignee: Grifols, S.A.Inventors: Daniel Martorell Pena, Ma del Carmen Traves Polo, Jordi Farre Leon, Josefina Castells Parera
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Publication number: 20140113355Abstract: A process for obtaining an IgG composition involves heat treatment. This process obtains an IgG composition from an IgG solution partly purified from human plasma, in which by applying intermediate heat treatment and without using reagents to precipitate high molecular weight aggregates/polymers and/or proteins virtually total elimination of the IgG polymers generated during the process is achieved. Furthermore this process offers high productivity, lower production costs and is easy to implement in comparison with the processes of the know art. In addition to this, by using this process stability is imparted to the final product in liquid.Type: ApplicationFiled: March 15, 2013Publication date: April 24, 2014Applicant: Grifols, S.A.Inventor: Grifols, S.A.
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Publication number: 20140100507Abstract: Methods and devices are described for reducing anticoagulant dilution of collected blood components during blood collection.Type: ApplicationFiled: May 24, 2012Publication date: April 10, 2014Applicant: Grifols, S.A.Inventor: Greg Flexman
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Patent number: 8690011Abstract: Device for emptying a bag containing a frozen blood-derived product, including: a cutting device; an extractor for the product, a hopper for receiving the product, a device for transporting the bag from a receiving area to the plasma extractor, this transporting device including a robotic arm with a gripper which, in turn, includes: two catching arms, each defining at least a distal end and a proximal end, and an actuator, in which the actuator controls a mechanism for modifying the distance separating the distal ends of the gripper arms to catch the bag by its lower surface.Type: GrantFiled: July 18, 2012Date of Patent: April 8, 2014Assignee: Grifols, S.A.Inventors: Sergi Roura Adell, Miquel Faba Vilella, Jordi Boira Bonhora
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Publication number: 20140026593Abstract: Described herein are devices and methods for thawing frozen biological products efficiently without harming the products.Type: ApplicationFiled: March 14, 2013Publication date: January 30, 2014Applicant: Grifols, S.A.Inventors: Ajoy VELAYUDHAN, Robert Large
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Patent number: 8574495Abstract: The apparatus comprises a single transportable structure provided with several separate compartments located in a vertical stack within a cabinet, with means for the vertical transport of gel cards, means for the transport of units for moving the cards and pipetting probes, being displaceable to the entire transverse cross-section of the compartments in at least two of the vertical compartments or floors through moving along coordinate axes X, Y, Z at right-angles, and control means so that automatic functioning can take place simultaneously with manual actions to load and unload the necessary materials (samples, reagents, cards, wash solutions and waste solutions) in a random manner.Type: GrantFiled: May 20, 2009Date of Patent: November 5, 2013Assignee: Grifols, S.A.Inventor: Marc Pellicer Sancho
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Publication number: 20130164273Abstract: The present invention provides a fibrinolytic composition useful as a therapeutic for administration to a patient having a thrombotic occlusion. In one aspect of the present invention, the fibrinolytic composition comprises a reversibly inactivated acidified serine protease substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent. In another aspect of the invention, the fibrinolytic composition of the present invention comprises a reversibly inactivated acidified plasmin substantially free of a plasminogen activator, a low buffering capacity buffer, and optionally, a stabilizing agent.Type: ApplicationFiled: February 7, 2013Publication date: June 27, 2013Applicant: Grifols, S.A.Inventor: Grifols, S.A.
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Patent number: 8376188Abstract: A device for the application of two components of fibrin adhesive at a treatment site comprising a support for syringes comprising two parallel cylindrical housings to receive corresponding syringes and a plunger connecting member, characterised in that the said syringe support comprises a passage for insertion of the said plunger connecting member, the said passage being located in the space defined between the cylindrical housings of the said syringe support, the said plunger connector having a zone with a suitable geometry to slide within the said passage and in that the transverse cross-section of the said passage of the syringe support has a maximum opening at the ends and a minimum opening in the central part.Type: GrantFiled: April 14, 2010Date of Patent: February 19, 2013Assignee: Grifols, S.A.Inventor: Jorge Maria Manzano Riera
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Patent number: 8354505Abstract: A concentrate of Von Willebrand Factor (VWF) or a complex of Factor VIII/VWF is prepared by creating a solution of VWF or a complex of Factor VIII/VWF containing VWF at a concentration of up to 12 IU VWF:RCo/ml and a VWF/Factor VIII ratio of 0.4 or more; and nanofiltering that starting solution through a filter of pore size of 35 nanometers or smaller. The resulting VWF retains high molecular weight multimers.Type: GrantFiled: January 7, 2009Date of Patent: January 15, 2013Assignee: Grifols, S.A.Inventors: Pere Ristol Debart, Maria Mercedes Faro Tomas, Juan Ignacio Jorquera Nieto
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Patent number: 8252590Abstract: The present invention relates to mammalian cell culture media which comprise supernatant from some of the fractions of human plasma fractionation according to the Cohn method, more specifically, the supernatant of fractions I and II+III. When said supernatant is added as a culture medium supplement it provides various nutrients and factors for the effective maintenance and/or proliferation of the cultured mammalian cells. In addition, the present invention relates to the preparation process and use of said medium in the culture of mammalian cells.Type: GrantFiled: July 2, 2010Date of Patent: August 28, 2012Assignee: Grifols, S.A.Inventors: Juan Ignacio Jorquera Nieto, Montserrat Costa Rierola, José María Diez Cervantes
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Patent number: 8231599Abstract: A process for detoxifying the blood of a patient in need thereof involves: collecting albumin from human plasma and/or plasma fractions; diafiltration of a mixture containing the collected albumin; stabilizing the resulting diafiltered albumin mixture with sodium chloride and an amino acid in the absence of any added fatty acid; pasteurizing the stabilized albumin mixture; diafiltering the pasteurized mixture to remove, among other things, stabilizers; and detoxifying the blood of the patient by administering the resulting albumin to the patient. In one embodiment, the amino acid stabilizing agent is acetyl tryptophan. The resulting albumin has at least about 80% albumin binding capacity relative to natural plasma albumin, and is storage stable for about 30 months at 30° C.Type: GrantFiled: February 15, 2011Date of Patent: July 31, 2012Assignee: Grifols, S.A.Inventors: Juan Ignacio Jorquera Nieto, Pere Ristol Debart, Montserrat Costa Rierola
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Patent number: 8088416Abstract: A process for purifying and collecting albumin from plasma and plasma fractions involves diafiltration of an albumin-containing plasma fraction; stabilizing the resulting albumin fraction with sodium chloride and an amino acid in the absence of any added fatty acid; pasteurizing the stabilized albumin fraction; and diafiltering the pasteurized fraction to remove, along other things, stabilizers. In one embodiment, the amino acid stabilizing agent is acetyl tryptophan. The resulting albumin has at least about 80% albumin binding capacity relative to natural plasma albumin, and is storage stable for about 30 months at 30° C.Type: GrantFiled: November 11, 2008Date of Patent: January 3, 2012Assignee: Grifols, S.A.Inventors: Juan Ignacio Jorquera Nieto, Pere Ristol Debart, Montserrat Costa Rierola