Abstract: A method is for calibrating a peristaltic pump, and for dispensing a quantity of liquid by a peristaltic pump. A device for producing sterile preparations can execute the methods.
Abstract: A machine is for the preparation of medical product. The machine includes a worktop for receiving containers. The worktop includes a series of holes for the introduction into each of them of an injection point belonging to a medical container to be filled. The holes give access to an interior of the machine, so that the injection points of the medical containers remain inside for their filling by the machine. The machine includes a removable device for loading medical containers into the machine. The removable device includes housings for the medical containers and detachable fasteners to the worktop of the machine.
Type:
Grant
Filed:
May 22, 2023
Date of Patent:
November 26, 2024
Assignee:
Kiro Grifols, S.L.
Inventors:
Borja Lizari Illarramendi, Naiara Telleria Garay, Patxi Urtzelai Aranbarri, Jose Ignacio Andres Pineda, Amaia Ilzarbe Andres
Abstract: A machine for the preparation of medical product includes a device for loading bags of medical product into the machine. The device includes a shaft with the ability to rotate and two or more adaptors for housing injection points of bags of medical product arranged on the shaft. The rotation of the shaft causes the adaptors arranged on the shaft to rotate. Two stops define a position for loading bags by an operator and an operating position of the machine.
Type:
Grant
Filed:
May 22, 2023
Date of Patent:
October 8, 2024
Assignee:
KIRO GRIFOLS, S.L.
Inventors:
Borja Lizari Illarramendi, Naiara Telleria Garay, Patxi Urtzelai Aranbarri, Jose Ignacio Andres Pineda, Amaia Ilzarbe Andres
Abstract: Method for the aseptic filling of a bag with a pharmaceutical product or liquid which comprises the following steps: a) a first step in which the cap is inserted in the inlet of the bag; b) a second step in which said cap is raised and the pharmaceutical product or liquid concerned is introduced; c) a third step in which the cap is re-inserted in the inlet of the bag; and d) a fourth step in which the cap and the inlet of the bag are welded.
Type:
Grant
Filed:
March 3, 2020
Date of Patent:
February 20, 2024
Assignee:
GRIFOLS, S.A.
Inventors:
Jordi Boira Bonhora, Miquel Faba Vilella, Daniel Fleta Coit
Abstract: Method for the aseptic filling of a bag with a pharmaceutical product or liquid which comprises the following steps: a) a first step in which the cap is inserted in the inlet of the bag; b) a second step in which said cap is raised and the pharmaceutical product or liquid concerned is introduced; c) a third step in which the cap is re-inserted in the inlet of the bag; and d) a fourth step in which the cap and the inlet of the bag are welded.
Type:
Grant
Filed:
March 3, 2020
Date of Patent:
November 28, 2023
Assignee:
GRIFOLS, S.A.
Inventors:
Jordi Boira Bonhora, Miquel Faba Vilella, Daniel Fleta Coit
Abstract: Device for labelling syringes for pharmaceutical products, comprising: means for feeding syringes to the device, a syringe manipulator configured to carry a syringe from the syringe-feeding means to the labelling station, a labelling station for labelling the syringes brought from the syringe-feeding means by means of the syringe manipulator, a control device for coordinating the aforementioned components, wherein the syringe-feeding means comprise a support for receiving a tray for holding one or more syringes, said support having a first position in which the syringe(s) on the tray is/are in a substantially vertical position.
Abstract: Device for handling a syringe and automated device for preparing intravenous medication comprising said device for handling a syringe The present invention discloses a device for handling a syringe, said syringe comprising a needle covered by a cap, said device comprising a main body which, in turn, comprises: a cap support comprising a housing for the cap of a needle, said housing being configured to hold said cap during removal and/or insertion of the needle from and/or into the cap by means of a linear movement; a device for joint removal of the cap and needle from the syringe by means of a rotation, comprising a slot defining two parallel faces spaced apart from each other and configured to interfere dimensionally with the cap of the syringe; at least one device for closing the syringe by means of a closed system transfer device (CSTD) or a cap, said device comprising a projection for fixing a support for said CSTD or cap, said support being replaceable and comprising a recess having a shape matching t
Abstract: A container for a solution of human plasma proteins has a primary inner bag made up of a first multilayer polymer film with two outer layers of polyethylene (PE) and an intermediate layer of ethylene vinyl alcohol (EVOH) copolymer, and a secondary outer bag made up of a second multilayer film with layers of polyethylene terephthalate (PET)-silicon oxides (SiOx), oriented polyamide (OPA), polypropylene (PP)-silicon oxides (SiOx) and polypropylene (PP), referred to as multilayer PP-SiOx.
Type:
Grant
Filed:
March 10, 2020
Date of Patent:
October 4, 2022
Assignee:
GRIFOLS, S.A.
Inventors:
Carlos Roura Fernandez, Jose Antonio Garcia Garcia, Estela Llorens Masas, Nuria Marzo Adam
Abstract: An adaptor for medical containers includes a hinge and a latch to attach the adaptor to respective support. The hinge includes a pivot to allow pivoting when a pivoting surface of the respective support and the pivot come in contact with each other. The adaptor can also include a zone for the reception of syringes, bags, vials and/or bottles.
Type:
Grant
Filed:
March 30, 2020
Date of Patent:
May 24, 2022
Assignee:
Kiro Grifols, S.L.
Inventors:
Borja Lizari Illarramendi, Ana Belen Barrio Jimenez, Amaia Ilzarbe Andres, Jose Ignacio Andres Pineda, Clara Molinuevo Portal, Pablo Lascurain Areitioaurtena
Abstract: Methods of treatment of NTM lung infections using formulations of liposomal ciprofloxacin. Specific liposome formulations and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations used in connection with such are described.
Type:
Grant
Filed:
June 26, 2020
Date of Patent:
September 14, 2021
Assignee:
GRIFOLS, S.A.
Inventors:
Igor Gonda, James Blanchard, David C. Cipolla, Luiz Eduardo Moreira Bermudez
Abstract: A concentrated inhalable formulation of an antibiotic drug such as ciprofloxacin is disclosed. The antibiotic is formulated with sodium acetate and liposome which incorporate antibiotic. The formulation is aerosolized and inhaled for treatment of respiratory tract infections and other medical conditions.
Abstract: A device for placing threaded lids on containers includes a holder for lids to be placed and a mechanism for retaining the lids stored in the holder. The retaining mechanism has a predetermined retaining position in which the lids stored in the holder are retained and a release position in which one of the lids stored in the holder is dispensed. The device also includes a lid positioner, which places a threaded lid on a container through a first rotation about a first axis when the positioner is in the placing position. When the position is in the receiving position, the positioner causes the retaining mechanism to change from the predetermined retaining position to the release position through rotation about the first axis.
Type:
Grant
Filed:
July 17, 2017
Date of Patent:
February 23, 2021
Assignee:
Kiro Grifols, S.L.
Inventors:
Borja Lizari Illarramendi, Amaia Ilzarbe Andres, Jose Ignacio Andres Pineda, Clara Molinuevo Portal
Abstract: Methods of treatment of NTM lung infections using formulations of liposoma ciprofloxacin. Specific liposome formulations and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations used in connection with such are described.
Type:
Application
Filed:
June 26, 2020
Publication date:
October 15, 2020
Applicant:
GRIFOLS, S.A.
Inventors:
Igor Gonda, James Blanchard, David C. Cipolla, Luiz Eduardo Moreira Bermudez
Abstract: A method is for calibrating a peristaltic pump, and for dispensing a quantity of liquid by a peristaltic pump. A device for producing sterile preparations that can execute the methods.
Abstract: An aerosolizable formulation comprised of a drug, a carrier and pH affecting component is disclosed. The Drug is dissolved in the formulation at a concentration above which it remains in solution at neutral pH. This increases the concentration of the drug in solution making it possible to administer larger amounts of drug with the same or a smaller volume of formulation. When the formulation is aerosolized to small particles and inhaled into human lungs in small volumes (e.g. 0.05 to 0.5 mL) the fluids in the lungs neutralize the formulation causing the drug to participate out of solution. This results in the drug being delivered at a controlled rate below the rate at which drug is administered from a formulation initially at a neutral pH.
Abstract: Method for the aseptic filling of a bag with a pharmaceutical product or liquid which comprises the following steps: a) a first step in which the cap is inserted in the inlet of the bag; b) a second step in which said cap is raised and the pharmaceutical product or liquid concerned is introduced; c) a third step in which the cap is re-inserted in the inlet of the bag; and d) a fourth step in which the cap and the inlet of the bag are welded.
Type:
Application
Filed:
March 3, 2020
Publication date:
June 25, 2020
Applicant:
GRIFOLS, S.A.
Inventors:
Jordi BOIRA BONHORA, Miquel FABA VILELLA, Daniel FLETA COIT
Abstract: Method for the aseptic filling of a bag with a pharmaceutical product or liquid which comprises the following steps: a) a first step in which the cap is inserted in the inlet of the bag; b) a second step in which said cap is raised and the pharmaceutical product or liquid concerned is introduced; c) a third step in which the cap is re-inserted in the inlet of the bag; and d) a fourth step in which the cap and the inlet of the bag are welded.
Type:
Application
Filed:
March 3, 2020
Publication date:
June 25, 2020
Applicant:
GRIFOLS, S.A.
Inventors:
Jordi BOIRA BONHORA, Miquel FABA VILELLA, Daniel FLETA COIT
Abstract: A labelling device for syringes for pharmaceutical products includes a carousel that holds and transports syringes, a syringe labelling station, a syringe handler, a camera for detecting the position of the marker scale of the syringes. The syringe labelling station includes an arm responsible for holding the label by a suction system and two articulated gates arranged such that when the syringe passes therethrough, the gates apply pressure over the body of the syringe in such a way that the label is affixed uniformly over the body.
Abstract: A device for loading medical containers on dosing machines includes an adaptor for medical containers and a support for the adaptor, in which the support includes an attachment means to the dosing machine and in which the adaptor and the support include means for pivoting relative to one another and means for clipping to each other. The means being arranged in such a way that the pivoting of the adaptor and of the support by means of the pivoting means produces the clipping together of the adaptor and the support.
Type:
Grant
Filed:
May 17, 2017
Date of Patent:
May 12, 2020
Assignee:
Kiro Grifols, S.L.
Inventors:
Borja Lizari Illarramendi, Ana Belen Barrio Jimenez, Amaia Ilzarbe Andres, Jose Ignacio Andres Pineda, Clara Molinuevo Portal, Pablo Lascurain Areitioaurtena
Abstract: A method and device for treating cholesterol disorders includes administering at least one treatment regime including two or more rounds of plasmapheresis to a patient having abnormal total cholesterol, abnormal LDL levels and/or abnormal HDL levels prior to treatment. Treatment according to the method results in decreased LDL levels in patients having abnormal LDL levels and increased HDL levels in patients having abnormal HDL levels. Each subsequent round of plasmapheresis is conducted weekly, but no more than twice per week.
Type:
Grant
Filed:
March 12, 2012
Date of Patent:
April 21, 2020
Assignee:
GRIFOLS, S.A.
Inventors:
Victor Grifols Lucas, Victor Grifols Roura