Abstract: A process for the monomethylation of nitrogenous heterocycles having at least one nitrogen atom bonded to a hydrogen atom by reacting the nitrogenous heterocycle with dimethyl carbonate at a temperature of between 100° and 200° C. and a pressure of between 0.93×105 Pa and 1.07×105 Pa while methanol produced during the reaction is distilled off as it is formed.
Type:
Grant
Filed:
July 31, 2003
Date of Patent:
April 4, 2006
Assignee:
Group SNPE
Inventors:
Elisabeth Borredon, Berhard Chabaud, Antoine Gaset, Sophie Thiebaud-Roux, Samedy Ouk