Abstract: The present invention relates to substituted propiolic acid amides, methods for the production thereof, medicaments containing these compounds and the use thereof for producing medicaments.
Type:
Grant
Filed:
June 26, 2008
Date of Patent:
August 30, 2011
Assignee:
Grüenthal GmbH
Inventors:
Michael Haurand, Klaus Schiene, Sven Kühnert, Melanie Reich, Saskia Zemolka
Abstract: Process for preparing a powder comprising the steps of providing at least one first component in liquid form at ambient temperature, providing at least one second component having a melting point or melting range in the range from above ambient temperature to below the degradation temperature of said first component, forming a homogenous liquid mixture comprising the at least one first component and the at least one second component by stirring and heating the mixture to or keeping the mixture at a temperature in the range from above the melting point or melting range of the second component and below the degradation temperature of the first component, transferring the liquid mixture to at least one spray congealing unit, spray congealing the mixture, and isolating the powder obtained upon spray congealing.
Type:
Application
Filed:
November 1, 2010
Publication date:
April 7, 2011
Applicant:
GRUENTHAL GMBH
Inventors:
Anne Faure, Jody Firim Marceline Voorspoels, Roel Jos M. Mertens, Filip René Irena Kiekens
Abstract: 1-phenyl-3-dimethylaminopropane compounds corresponding to the formula I
a method of preparing them, and the use of these substances as analgesic active ingredients in pharmaceutical compositions.
Type:
Grant
Filed:
April 20, 2001
Date of Patent:
February 5, 2002
Assignee:
Gruenthal GmbH
Inventors:
Helmut Buschmann, Wolfgang Strassburger, Elmar Friderichs