Patents Assigned to Gruppo Lepetit S.p.A.
  • Antibiotic GE 2270 factors C.sub.2a
    Patent number: 5514649
    Abstract: The present invention is directed to a new antibiotic substance denominated antibiotic GE 2270 factor C.sub.2a, the addition salts thereof, the pharmaceutical compositions thereof and its use as medicament, particularly in the treatment of infectious diseases involving microorganisms susceptible to it and its use as animal growth promoter.
    Type: Grant
    Filed: April 21, 1995
    Date of Patent: May 7, 1996
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Enrico Selva, Sergio Stella, Luigi Colombo, Maurizio Denaro
  • Substituted alkylamide derivatives of teicoplanin
    Patent number: 5500410
    Abstract: The present invention is directed to new C.sup.63 amide derivatives of teicoplanin wherein the amide moiety is derived from a di- or poly-alkylamine, and to a process for preparing them. The derivatives are prepared by reacting a teicoplanin-like product with an active ester forming reagent such as chloroacetonitrile and then contacting said active ester with the appropriate di- or poly-alkylamine. The amide derivatives of the invention are active against gram positive and gram negative bacteria.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: March 19, 1996
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Adriano Malabarba, Pierfausto Seneci, Jurgen K. Kettenring, Romeo Ciabatti
  • Aglycons of A/16686 antibiotics
    Patent number: 5491128
    Abstract: The invention concerns the aglycons of factors A1, A2, A3, A'1, A'2, A'3 of antibiotic A/16686, their corresponding tetrahydroderivatives and mixtures thereof. The aglycons are produced by the selective hydrolysis of antibiotic A/16686 factor A1, A2, A3, A'1, A'2 or A'3. The compounds have antibacterial activity against widely diffused gram positive bacteria and are particularly useful for topical treatment of wound infections and acne.
    Type: Grant
    Filed: April 19, 1995
    Date of Patent: February 13, 1996
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Romeo Ciabatti, Bruno Cavalleri
  • Teicoplanin recovery process
    Patent number: 5486465
    Abstract: The present invention relates to a method for extracting teicoplanin A.sub.2 from a whole culture fermentation broth by filtration of the mycelium in an alkaline medium and recovery by extraction of the filtered fermentation broth with organic solvents or mixtures thereof or by adsorption onto suitable matrixes.
    Type: Grant
    Filed: March 29, 1995
    Date of Patent: January 23, 1996
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Anacleto Giantonio, Gianbattista Panzone
  • 7'-amino-naphthazarin antibiotic derivatives
    Patent number: 5475010
    Abstract: The present invention concerns novel naphthazarin antibiotic derivatives having general formula I ##STR1## and the pharmaceutically acceptable addition salts thereof.
    Type: Grant
    Filed: May 26, 1994
    Date of Patent: December 12, 1995
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Aldo Trani, Clelia M. L. Dallanoce, Romeo Ciabatti
  • Hexapeptides deriving from aglucoteicoplanin and a process for preparing them
    Patent number: 5438117
    Abstract: Hexapeptides of formula (I) deriving from aglucoteicoplanin and their salts with acids and bases as well as their inner salts wherein R is hydrogen or a protecting ##STR1## group of the amino function. The products of formula (I), wherein R is hydrogen, possess antimicrobial activity in particular against coagulase-negative strains and some S. aureus and S. epidermidis strains which have low sensitivity toward teicoplanin. The hexapeptides are produced by reductive cleavage of aglucoteicoplanin with alkali metal borohydrides in the presence of a hydroalcoholic mixture as solvent.
    Type: Grant
    Filed: June 23, 1994
    Date of Patent: August 1, 1995
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Adriano Malabarba, Romeo Ciabatti
  • Process for preparing 2'-(diethylamino)rifamycin P (P/DEA)
    Patent number: 5378837
    Abstract: The present invention relates to a new one-pot process for preparing 2'-(diethylamino)rifamycin P and its 25-desacetyl derivative which consists in cyclizing 3-bromorifamycin S or its 25-desacetyl derivative, dissolved in dimethylformamide, with 1,1-diethylthiourea and reducing, without isolation, the obtained 1,2-quinonimine intermediate with a mild reducing agent.
    Type: Grant
    Filed: October 8, 1993
    Date of Patent: January 3, 1995
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Gianbattista Panzone, Anacleto Gianantonio
  • Antibiotic GE 2270
    Patent number: 5322777
    Abstract: The present invention is directed to a new antibiotic substance denominated antibiotic GE 2270, the addition salts thereof, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them.
    Type: Grant
    Filed: October 14, 1992
    Date of Patent: June 21, 1994
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Enrico Selva, Nicoletta Montanini, Graziella Beretta, Beth P. Goldstein, Maurizio Denaro
  • Antibiotic GE 2270
    Patent number: 5202241
    Abstract: The present invention is directed to a new antibiotic substance denominated antibiotic GE 2270, the addition salts thereof, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them.
    Type: Grant
    Filed: June 11, 1991
    Date of Patent: April 13, 1993
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Enrico Selva, Nicoletta Montanini, Graziella Beretta, Beth P. Goldstein, Maurizio Denaro
  • Substituted alkylamides of teicoplanin compounds
    Patent number: 5198418
    Abstract: The present invention is directed to teicoplanin derivatives in which position 63 of the glycopeptide core is substituted with a substituted alkylamide.
    Type: Grant
    Filed: January 21, 1992
    Date of Patent: March 30, 1993
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Adriano Malabarba, Giorgio Tarzia
  • O.sup.56 -alkyl derivatives of aglycone and pseudo aglycones of teicoplanin
    Patent number: 5185320
    Abstract: The present invention is directed to a new class of teicoiplanin derivatives, a process for preparing them and their use as pharmaceutically active substances.
    Type: Grant
    Filed: May 22, 1991
    Date of Patent: February 9, 1993
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Aldo Trani, Pierfausto Seneci, Pietro Ferrari, Romeo Ciabatti
  • De-(acetylglucosaminyl-di(dehydro)-deoxy teicoplanin derivatives
    Patent number: 5164484
    Abstract: The present invention is directed to new de-(acetylglucosaminyl)-di(dehydro)deoxy teicoplanin derivatives which possess antibiotic activity mainly against gram positive bacteria.The new compounds are obtained by chemical modification of a teicoplanin antibiotic substance.
    Type: Grant
    Filed: October 21, 1991
    Date of Patent: November 17, 1992
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Adriano Malabarba, Pietro Ferrari, Aldo Trani, Giorgio Tarzia
  • Well forming apparatus
    Patent number: 5156074
    Abstract: The present invention relates to an apparatus which is able to form a desired number of wells in gelatinous media, as for example agar-based media contained in dishes or plates such as the normal microbiological culture dishes or plates.
    Type: Grant
    Filed: June 22, 1989
    Date of Patent: October 20, 1992
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Angelo De Ros, Luigi Cavenaghi
  • Purpuromycin for the treatment of vaginal infections and pharmaceutical dosage forms for said use
    Patent number: 5141953
    Abstract: Use of the antibiotic purpuromycin for the topical treatment of infectious vaginitis and topical dosage forms containing said product. The antibiotic purpuromycin is simultaneously active against the main causative agents of infectious vaginitis i.e.: Candida vaginalis, Trichomonas vaginalis and Gardnerella vaginalis.
    Type: Grant
    Filed: March 22, 1990
    Date of Patent: August 25, 1992
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Francesco Parenti, Beth P. Goldstein, Luigi Simioni
  • Process for the preparation of de-mannosyl teicoplanin derivatives
    Patent number: 5135857
    Abstract: The object of this invention are de-mannosylated teicoplanin derivatives which can be obtained in good yield by microbiological transformation with cultures of Nocardia orientalis NRRL 2450 or Streptomyces candidus NRRL 3218.
    Type: Grant
    Filed: July 12, 1991
    Date of Patent: August 4, 1992
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Angelo Borghi, Giancarlo Lancini, Piero Antonini
  • Composition of antibiotic L 17054 and a method for the treatment of bacterial infections using the antibiotic
    Patent number: 5132286
    Abstract: The present invention is directed to the essentially pure preparation of an antibiotic substance arbitrarily designated antibiotic L 17054. This antibiotic substance is obtained from the known antibiotic substance named teicoplanin (formerly teichomycin) by chemical treatment. The new compound and the pharmaceutically acceptable salts possess antimicrobial activity.
    Type: Grant
    Filed: May 17, 1991
    Date of Patent: July 21, 1992
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Adriano Malabarba, Angelo Borghi, Paolo Strazzolini, Bruno Cavalleri, Carolina Coronelli
  • Water soluble salts of purpuromycin and pharmaceutical formulations thereof
    Patent number: 5118705
    Abstract: Water soluble salts of purpuromycin, their use for the topical treatment of infectious vaginitis and topical dosage forms containing said products. Oral and parenteral formulations for administration of the water soluble purpuromycin salts. The water soluble salts of purpuromycin are simultaneously active against the main causative agents of infectious vaginitis i.e.: Candida vaginalis, Trichomonas vaginalis and Gardnerella vaginalis.
    Type: Grant
    Filed: February 25, 1991
    Date of Patent: June 2, 1992
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Aldo Trani, Sergio Bellini, Beth P. Goldstein, Luigi Simioni
  • Hydrogenated derivatives of antibiotic A/16686
    Patent number: 5108988
    Abstract: The invention concerns tetrahydroderivatives of factors A1, A2, A3, A'1, A'2, A'3 of antibiotic A/16686 and mixtures thereof. The tetrahydroderivatives are produced by hydrogenation of the above mentioned factors, preferably by catalytic hydrogenation.The compounds have antibacterial activity, in particular, against widely diffused gram positive bacteria and are particularly useful for topical treatment of wound infections and acne.
    Type: Grant
    Filed: December 5, 1988
    Date of Patent: April 28, 1992
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Romeo Ciabatti, Bruno Cavalleri
  • Teicoplanin-like derivatives
    Patent number: 5085990
    Abstract: The present invention relates to new teicoplanin-like antibiotics differing from the parent compound in the length of the acyl group.The compounds of the invention are obtained according to a microbiological process and possess an antimicrobiol activity mainly against gram positive bacteria.
    Type: Grant
    Filed: May 10, 1991
    Date of Patent: February 4, 1992
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Giancarlo Lancini, Angelo Borghi, Piero Antonini, Raffaele Palumbo
  • De-mannosyl teicoplanin derivatives
    Patent number: 5064811
    Abstract: The oject of this invention are de-mannosylated teicoplanin derivatives which can be obtained in good yield by microbiological transformation with cultures of Nocardia orientalis NRRL 2450 or Streptomyces candiodus NRRL 3218.
    Type: Grant
    Filed: February 13, 1991
    Date of Patent: November 12, 1991
    Assignee: Gruppo LePetit S.p.A.
    Inventors: Angelo Borghi, Giancarlo Lancini, Piero Antonini