Abstract: An interspinous fusion device includes a central body defining a longitudinal direction and configured to be inserted between two adjacent spinous processes; and a proximal body and a distal body, opposite to each other with respect to the central body and configured to relatively translate towards each other along the longitudinal direction. A pair of proximal jaws and a pair of distal jaws opposite to each other with respect to the central body are spaced apart from each other along the longitudinal direction, and have a first end connected by hinges to the proximal body or to the distal body and a second end configured to abut against a spinous process. An actuation system percutaneously actuates the proximal and distal bodies to cause relative translation and rotation of the jaws about the proximal body and the distal body, thereby opening and closing the jaws.