Patents Assigned to Gtx
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Patent number: 11272761Abstract: A novel tracking system is disclosed. In one embodiment, a long-range tracking device is incorporated into a removable footwear insole and a short-range tracking device is incorporated into another removable footwear insole. The long-range tracking device includes a location determining device, a wireless communication device, and a power source. In a more particular embodiment, the location determining device is a GPS receiver, and the communication device is a cellular modem.Type: GrantFiled: July 10, 2020Date of Patent: March 15, 2022Assignee: GTX CorpInventors: Patrick E. Bertagna, Andrew Hamish Duncan, Li Wang, Adam Solis
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Publication number: 20210228426Abstract: Systems, devices, and methods for monitoring and treating a patient on route to a medical facility are disclosed. The system comprises a critical care unit; at least one patient monitoring device coupled to the critical care unit, wherein the critical care unit obtains physiological data about the patient from each patient monitoring device; at least one patient treatment device coupled to the critical care unit, wherein the critical care unit provides treatment instructions to each patient treatment device; a two way communications device coupled to the critical care unit; and a remote communications terminal in communication with the two way communications device. The critical care unit preferably sends the physiological data to the remote communications terminal and receives the treatment instructions from the remote communications terminal via the two way communications device.Type: ApplicationFiled: January 5, 2021Publication date: July 29, 2021Applicant: Athena GTX, Inc.Inventors: Mark Darrah, Cesar Gradilla, John Elson, Gregory T. Darrah, Allen E. Brandenburg
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Patent number: 10893989Abstract: Systems, devices, and methods for monitoring and treating a patient on route to a medical facility are disclosed. The system comprises a critical care unit; at least one patient monitoring device coupled to the critical care unit, wherein the critical care unit obtains physiological data about the patient from each patient monitoring device; at least one patient treatment device coupled to the critical care unit, wherein the critical care unit provides treatment instructions to each patient treatment device; a two way communications device coupled to the critical care unit; and a remote communications terminal in communication with the two way communications device. The critical care unit preferably sends the physiological data to the remote communications terminal and receives the treatment instructions from the remote communications terminal via the two way communications device.Type: GrantFiled: June 29, 2018Date of Patent: January 19, 2021Assignee: Athena GTX, Inc.Inventors: Mark Darrah, Cesar Gradilla, John Elson, Gregory T. Darrah, Allen E. Brandenburg
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Patent number: 10799702Abstract: The present disclosure relates to a system for neuromodulation and/or neurostimulation, for the treatment of a subject. The system comprises a stimulation controller, a stimulation pattern storage means including stimulation data connected to the stimulation controller, an electrical stimulation device and electrical interface between the electrical stimulation device and the subject, the electrical interface being connectable with a bio-interface of the nervous system of the subject. The stimulation data are pre-programmed patterns comprising spatial and temporal components, The stimulation controller sends configuration signals on the basis of the stimulation data to the electrical stimulation device such that via the electrical interface electrical stimulation is provided to the bio-interface, wherein the electrical stimulation provided is characterized by stimulation parameters that vary over time in a pre-programmed manner.Type: GrantFiled: May 25, 2018Date of Patent: October 13, 2020Assignee: GTX MEDICAL B.V.Inventors: Karen Minassian, Fabien Wagner, Grégoire Courtine
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Patent number: 10751539Abstract: The present disclosure relates to an active closed-loop medical system comprising at least one implantable medical device, at least one non-implanted component and at least a controller for controlling the implantable medical device, wherein the implantable medical device, the non-implanted component and the controller are connected for data exchange, wherein the implantable medical device, the non-implanted component and the controller forming in the active state a closed-loop system in such that the implantable medical device is controlled by the controller on the basis of the signals exchanged with the non-implanted component.Type: GrantFiled: November 15, 2017Date of Patent: August 25, 2020Assignee: GTX MEDICAL B.V.Inventors: Joachim Von Zitzewitz, Vincent Delattre, Bert Bakker, Grégoire Courtine
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Patent number: 10743615Abstract: A novel tracking system is disclosed. In one embodiment, a long-range tracking device is incorporated into a removable footwear insole and a short-range tracking device is incorporated into another removable footwear insole. The long-range tracking device includes a location determining device, a wireless communication device, and a power source. In a more particular embodiment, the location determining device is a GPS receiver, and the communication device is a cellular modem.Type: GrantFiled: March 29, 2019Date of Patent: August 18, 2020Assignee: GTX CorpInventors: Patrick E. Bertagna, Andrew Hamish Duncan, Li Wang, Adam Solis
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Publication number: 20200024270Abstract: The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.Type: ApplicationFiled: February 21, 2019Publication date: January 23, 2020Applicants: GTx, Inc., UNIVERSITY OF TENNESSEE RESEARCH FOUNDATIONInventors: Wei Li, Min Xiao, James Dalton, Sunjoo Ahn, Duane D. Miller, Jin Wang
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Publication number: 20190350312Abstract: A novel tracking system is disclosed. In one embodiment, a long-range tracking device is incorporated into a removable footwear insole and a short-range tracking device is incorporated into another removable footwear insole. The long-range tracking device includes a location determining device, a wireless communication device, and a power source. In a more particular embodiment, the location determining device is a GPS receiver, and the communication device is a cellular modem.Type: ApplicationFiled: March 29, 2019Publication date: November 21, 2019Applicant: GTX Corp.Inventors: Patrick E. Bertagna, Andrew Hamish Duncan, Li Wang, Adam Solis
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Patent number: 10441570Abstract: This invention provides novel indole, indazole, benzimidazole, benzotriazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating hyperproliferations of the prostate including pre-malignancies and benign prostatic hyperplasia, prostate cancer, advanced prostate cancer, castration resistant prostate cancer, other AR-expressing cancers, androgenic alopecia or other hyper androgenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels (through degradation) and/or activity (through inhibition) of any androgen receptor including androgen receptor-full length (AR-FL) including pathogenic and/or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.Type: GrantFiled: May 16, 2018Date of Patent: October 15, 2019Assignees: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION, GTX, INC.Inventors: Ramesh Narayanan, Duane D. Miller, Thamarai Ponnusamy, Dong-Jin Hwang, Yali He, Jayaprakash Pagadala, Charles B. Duke, Christopher C. Coss, James T. Dalton
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Patent number: 10361001Abstract: Systems, devices, and methods for monitoring and treating a patient on route to a medical facility are disclosed. The system comprises a critical care unit; at least one patient monitoring device coupled to the critical care unit, wherein the critical care unit obtains physiological data about the patient from each patient monitoring device; at least one patient treatment device coupled to the critical care unit, wherein the critical care unit provides treatment instructions to each patient treatment device; a two way communications device coupled to the critical care unit; and a remote communications terminal in communication with the two way communications device. The critical care unit preferably sends the physiological data to the remote communications terminal and receives the treatment instructions from the remote communications terminal via the two way communications device.Type: GrantFiled: September 23, 2016Date of Patent: July 23, 2019Assignee: Athena GTX, Inc.Inventors: Mark Darrah, Cesar Gradilla, John Elson, Ellen Miller
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Patent number: 10314807Abstract: This invention relates to the treatment of breast cancer in a subject, for example a female subject. Including methods of: treating metastatic breast cancer; refractory breast cancer; AR-positive breast cancer; AR-positive refractory breast cancer; AR-positive metastatic breast cancer; AR-positive and ER-positive breast cancer; triple negative breast cancer; advanced breast cancer; breast cancer that has failed SERM (tamoxifen, toremifene), aromatase inhibitor, palbociclib (Ibrance), trastuzumab (Herceptin, ado-trastuzumab emtansine), pertuzumab (Perjeta), lapatinib, exemestane (Aromasin), bevacizumab (Avastin), and/or fulvestrant treatments; metastasis in a subject suffering from breast cancer; and/or HER2-positive; comprising administering to the subject a therapeutically effective amount of a selective androgen receptor modulator (SARM) compound.Type: GrantFiled: December 6, 2016Date of Patent: June 11, 2019Assignee: GTX, INC.Inventors: James T. Dalton, Mitchell S. Steiner, Ramesh Narayanan, Sunjoo Ahn
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Patent number: 10301285Abstract: The present invention relates to a compound of formula XXII and a compound of formula 17ya, which are defined as anywhere in the specification, to a composition comprising the same, and to a method of using thereof in the treatment of various forms of cancer.Type: GrantFiled: April 21, 2015Date of Patent: May 28, 2019Assignees: GTX, INC., UNIVERSITY OF TENNESSEE RESEARCH FOUNDATIONInventors: Duane D. Miller, Jianjun Chen, James T. Dalton, Chien-Ming Li, Sunjoo Ahn, Wei Li
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Patent number: 10292453Abstract: A novel tracking system is disclosed. In one embodiment, a long-range tracking device is incorporated into a removable footwear insole and a short-range tracking device is incorporated into another removable footwear insole. The long-range tracking device includes a location determining device, a wireless communication device, and a power source. In a more particular embodiment, the location determining device is a GPS receiver, and the communication device is a cellular modem.Type: GrantFiled: December 29, 2017Date of Patent: May 21, 2019Assignee: GTX CorpInventors: Patrick E. Bertagna, Andrew Hamish Duncan, Li Wang, Adam Solis
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Publication number: 20190125716Abstract: This invention relates to the treatment of breast cancer in a subject, for example a female subject.Type: ApplicationFiled: January 8, 2019Publication date: May 2, 2019Applicant: GTx, INC.Inventors: Mitchell S. STEINER, Ramesh Narayanan, Sunjoo Ahn, James T. Dalton
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Publication number: 20190111010Abstract: This invention relates to the treatment of breast cancer in a subject, for example a female subject.Type: ApplicationFiled: July 31, 2018Publication date: April 18, 2019Applicant: GTX, INC.Inventors: Ramesh NARAYANAN, Thamarai PONNUSAMY
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Patent number: 10258596Abstract: This invention relates to the treatment of breast cancer in a subject, for example a female subject. Including methods of: treating metastatic breast cancer; refractory breast cancer; AR-positive breast cancer; AR-positive refractory breast cancer; AR-positive metastatic breast cancer; AR-positive and ER-positive breast cancer; triple negative breast cancer; advanced breast cancer; breast cancer that has failed SERM (tamoxifen, toremifene), aromatase inhibitor, palbociclib (Ibrance), trastuzumab (Herceptin, ado-trastuzumab emtansine), pertuzumab (Perjeta), lapatinib, exemestane (Aromasin), bevacizumab (Avastin), and/or fulvestrant treatments; metastasis in a subject suffering from breast cancer; and/or HER2-positive; comprising administering to the subject a therapeutically effective amount of a selective androgen receptor modulator (SARM) compound.Type: GrantFiled: March 21, 2016Date of Patent: April 16, 2019Assignee: GTx, Inc.Inventors: James T. Dalton, Mitchell S. Steiner, Ramesh Narayanan, Sunjoo Ahn
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Patent number: 10252065Abstract: The present disclosure relates to a pulse generating system comprising a pulse generator for generating a pulse or pulses and a controller for controlling the pulse generating means, where the pulse generating system is capable to work in at least a regular mode and a safety mode, where in the regular mode the pulse generator and the controller are connected and where in the safety mode there is no connection between the pulse generator and the controller and where in the safety mode the pulse generator automatically switches to a baseline stimulation command.Type: GrantFiled: July 13, 2017Date of Patent: April 9, 2019Assignee: GTX medical B.V.Inventors: Vincent Delattre, Joachim Von Zitzewitz, Sjaak Deckers
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Publication number: 20180360805Abstract: This invention provides novel indole, indazole, benzimidazole, benzotriazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating hyperproliferations of the prostate including pre-malignancies and benign prostatic hyperplasia, prostate cancer, advanced prostate cancer, castration resistant prostate cancer, other AR-expressing cancers, androgenic alopecia or other hyper androgenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels (through degradation) and/or activity (through inhibition) of any androgen receptor including androgen receptor-full length (AR-FL) including pathogenic and/or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.Type: ApplicationFiled: May 16, 2018Publication date: December 20, 2018Applicants: GTx, Inc., University of Tennessee Research FoundationInventors: Ramesh NARAYANAN, Duane D. MILLER, Thamarai PONNUSAMY, Dong-Jin HWANG, Yali HE, Jayaprakash PAGADALA, Charles B, DUKE, Christopher C. COSS, James T. DALTON
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Patent number: 10155728Abstract: The present invention relates to colchicine-binding site compounds having anti-cancer activity, compositions comprising the same, and their use for treating various forms of cancer.Type: GrantFiled: December 29, 2017Date of Patent: December 18, 2018Assignees: GTX INC., UNIVERSITY OF TENNESSEE RESEARCH FOUNDATIONInventors: Yan Lu, James T Dalton, Wei Li, Duane D Miller
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Patent number: D907206Type: GrantFiled: November 29, 2018Date of Patent: January 5, 2021Assignee: GTX MEDICAL B.V.Inventors: Damien Ganty, Egbertus Bakker, Jacobus Deckers, Edoardo Paoles, Vincent Delattre, Jocelyne Bloch, Grégoire Courtine, Marco Capogrosso, Fabien Wagner, Nathan Greiner, Karen Minassian