Patents Assigned to GUANGZHOU HYBRIBIO MEDICINE TECHNOLOGY LTD.
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Publication number: 20240416343Abstract: The present invention relates to a microfluidic chip for sorting living cells. A sample flow channel communicates with a liquid inlet end of a sorting flow channel. A gas inlet flow channel, a target flow channel and a non-target flow channel communicate with a liquid outlet end of the sorting flow channel. An included angle between the target flow channel and the sorting flow channel is from 100° to 130°, and an included angle between the non-target flow channel and the sorting flow channel is from 100° to 140°. A distance between an intersection of an axis of the gas inlet flow channel and an axis of the sorting flow channel and an intersection of the sorting flow channel, the target flow channel and the non-target flow channel is from 0.02 mm to 0.05 mm.Type: ApplicationFiled: January 4, 2024Publication date: December 19, 2024Applicants: GUANGZHOU HYBRIBIO MEDICINE TECHNOLOGY LTD., HYBRIBIO MEDTECH DEVICE CO., LTD, GUANGDONG HYBRIBIO BIOTECH CO., LTD.Inventors: Yongguang WU, Xiang CHEN, Yan ZHENG, Mengyu LIU, Jianhang XIAO, Longxu XIE
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Patent number: 11796443Abstract: The present invention discloses a method for isolating placental trophoblast cells from cervical exfoliated cells of a pregnant woman. Based on a specific antigen or combination expressed on the surface or inside of specific trophoblast cells, the designed microfluidic sorting chip or flow cytometer is used in the method to perform cell sorting of a cell suspension of a placental trophoblast sample, thus obtaining isolated and purified placental trophoblast cells. Compared with conventional methods, the method of the present invention has the advantages of non-invasively obtaining specimens and good specificity. Moreover, the method causes low risk of infection and abortion, allows earlier sampling time and can achieve the synchronous labeling of a plurality of antigens as well as identification and sorting of characteristic fluorescence signals; and the method has greatly improved accuracy and higher reliability and broader coverage area of detection results.Type: GrantFiled: March 16, 2022Date of Patent: October 24, 2023Assignees: GUANGZHOU HYBRIBIO MEDICINE TECHNOLOGY LTD., GUANGDONG HYBRIBIO BIOTECH CO., LTD.Inventors: Yan Zheng, Jiayan Ma, Xiaowei Feng, Mengyu Liu, Peixuan Chen, Zhisheng Guan, Longxu Xie, Yiyuan Ge
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Publication number: 20230228667Abstract: The present invention discloses a method for isolating placental trophoblast cells from cervical exfoliated cells of a pregnant woman. Based on a specific antigen or combination expressed on the surface or inside of specific trophoblast cells, the designed microfluidic sorting chip or flow cytometer is used in the method to perform cell sorting of a cell suspension of a placental trophoblast sample, thus obtaining isolated and purified placental trophoblast cells. Compared with conventional methods, the method of the present invention has the advantages of non-invasively obtaining specimens and good specificity. Moreover, the method causes low risk of infection and abortion, allows earlier sampling time and can achieve the synchronous labeling of a plurality of antigens as well as identification and sorting of characteristic fluorescence signals; and the method has greatly improved accuracy and higher reliability and broader coverage area of detection results.Type: ApplicationFiled: March 16, 2022Publication date: July 20, 2023Applicants: GUANGZHOU HYBRIBIO MEDICINE TECHNOLOGY LTD., GUANGDONG HYBRIBIO BIOTECH CO., LTD.Inventors: Yan ZHENG, Jiayan MA, Xiaowei FENG, Mengyu LIU, Peixuan CHEN, Zhisheng GUAN, Longxu XIE, Yiyuan GE
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Patent number: 11564891Abstract: A product for preventing and treating external genitalia infection and/or flat warts is provided, wherein the product comprises a chloroquine nanosphere. The chloroquine nanosphere comprises a water-soluble nanosphere carrier, and chloroquine or a chloroquine derivative. A mass ratio of the chloroquine or the chloroquine derivative to the water-soluble nanosphere carrier during preparation ranges from 1:3 to 1:5. A loading rate of the chloroquine or the chloroquine derivative in the prepared chloroquine nanosphere ranges from 3.0% to 21.6%. The water-soluble nanosphere carrier is water-soluble chitosan; a deacetylation degree of the water-soluble chitosan ranges from 80% to 95%, and a viscosity-average molecular weight thereof ranges from 3000 to 5000 g/mol. The chloroquine derivative is selected from one or more of hydroxychloroquine, chloroquine phosphate or chloroquine sulfate.Type: GrantFiled: September 10, 2021Date of Patent: January 31, 2023Assignees: GUANGZHOU HYBRIBIO MEDICINE TECHNOLOGY LTD., GUANGZHOU HYBRIBIO BIOTECH LTD.Inventors: Longxu Xie, Xiangling Li, Manli Yuan, Ting Wang, Jianyu Wang
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Publication number: 20210401763Abstract: A product for preventing and treating external genitalia infection and/or flat warts is provided, wherein the product comprises a chloroquine nanosphere. The chloroquine nanosphere comprises a water-soluble nanosphere carrier, and chloroquine or a chloroquine derivative. A mass ratio of the chloroquine or the chloroquine derivative to the water-soluble nanosphere carrier during preparation ranges from 1:3 to 1:5. A loading rate of the chloroquine or the chloroquine derivative in the prepared chloroquine nanosphere ranges from 3.0% to 21.6%. The water-soluble nanosphere carrier is water-soluble chitosan; a deacetylation degree of the water-soluble chitosan ranges from 80% to 95%, and a viscosity-average molecular weight thereof ranges from 3000 to 5000 g/mol. The chloroquine derivative is selected from one or more of hydroxychloroquine, chloroquine phosphate or chloroquine sulfate.Type: ApplicationFiled: September 10, 2021Publication date: December 30, 2021Applicants: GUANGZHOU HYBRIBIO MEDICINE TECHNOLOGY LTD., GUANGZHOU HYBRIBIO BIOTECH LTD.Inventors: Longxu XIE, Xiangling LI, Manli YUAN, Ting WANG, Jianyu WANG
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Patent number: 11147773Abstract: A chloroquine gel and a preparation method and application thereof. A chloroquine nanosphere includes a water-soluble nanosphere carrier, and chloroquine or a chloroquine derivative, wherein a mass ratio of the chloroquine or the chloroquine derivative to the water-soluble nanosphere carrier is no more than 1:3.Type: GrantFiled: November 4, 2019Date of Patent: October 19, 2021Assignees: GUANGZHOU HYBRIBIO MEDICINE TECHNOLOGY LTD., GUANGZHOU HYBRIBIO BIOTECH LTD.Inventors: Longxu Xie, Xiangling Li, Manli Yuan, Ting Wang, Jianyu Wang
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Publication number: 20200397713Abstract: A chloroquine gel and a preparation method and application thereof. A chloroquine nanosphere includes a water-soluble nanosphere carrier, and chloroquine or a chloroquine derivative, wherein a mass ratio of the chloroquine or the chloroquine derivative to the water-soluble nanosphere carrier is no more than 1:3.Type: ApplicationFiled: November 4, 2019Publication date: December 24, 2020Applicants: GUANGZHOU HYBRIBIO MEDICINE TECHNOLOGY LTD., GUANGZHOU HYBRIBIO BIOTECH LTD.Inventors: Longxu XIE, Xiangling LI, Manli YUAN, Ting WANG, Jianyu WANG