Abstract: The present invention discloses a polyvalent metal ion compound salt of N,N-dimethylglycine and organic acid or a solvate thereof, and use thereof in preparing novel feed additives and feed; the present invention also discloses a composition comprising the polyvalent metal ion compound salt of N,N-dimethylglycine and organic acid or the solvate thereof. The polyvalent metal ion compound salt of N,N-dimethylglycine and organic acid or the solvate thereof provided by the present invention has improvement effect on animal product performance such as improving animal weight gain and reducing feed conversion ratio, showing effects similar to or higher than that of sodium N,N-dimethylglycinate.

Abstract: Provided is a method of using a copper-calcium sulphate as an animal feed additive. When used in animal breeding, a low dose of the copper-calcium sulphate can achieve the effect of that high dosage of copper sulphate achieve in the promotion of animal growth, and thus the copper-calcium sulphate can be used as an animal basic nutritional supplement to substitute low-copper preparations in the breeding of poultry, livestock or aquatic animals. Copper-calcium sulphate, used as a novel, efficient and safe feed additive in the feed processing industry and animal breeding industry, can reduce the dosage of copper ion by nearly 50-70% to achieve the same production performance, can significantly reduce the use of copper in animal husbandry, and can reduce the production costs, reduce the toxic side effects of a high level of copper, and reduce the environmental pollution, thus the copper-calcium sulphate is a copper compound with unique advantages.

Abstract: A use of a substituted benzoguanidine derivative as a polymyxin antibiotic synergist, particularly as a synergist and a drug resistance reversal agent of the polymyxin antibiotic for inhibiting a sensitive strain, or a composition comprising the same in combination with a polymyxin antibiotic for preparing a compound pharmaceutical preparation for human or animal use in the treatment of a disease caused by a gram-negative bacterial infection or the preparation a growth-promoting feed additive and for the raising of livestock animals.

Abstract: The present invention relates to a conjugate salt of N,N-dimethylglycine with metal and organic acid, and a preparation method and use thereof. The conjugate salt of N,N-dimethylglycine with metal and organic acid has a following structural formula: [(CH3)2NCH2COO]nM.[Organic acid], wherein, n is 1 or 2; M is selected from an alkali metal ion or a divalent metal ion; the organic acid is selected from an organic polyacid, a C2-C18 linear fatty acid or an aromatic acid. The conjugate salt of N,N-dimethylglycine with metal and organic acid is a conjugate acid salt formed by introducing another organic acid with a hydrophobic group into the salt of N,N-dimethylglycine and a metal ion, so as to modify the hygroscopicity of N,N-dimethylglycine by decreasing the affinity of the salt toward water molecules in the air, or decreasing the affinity or attraction of molecular aggregates formed through crystalline behavior of the salt toward water molecules in the air.

Abstract: The present invention discloses a polyvalent metal ion compound salt of N,N-dimethylglycine and organic acid or a solvate thereof, and use thereof in preparing novel feed additives and feed; the present invention also discloses a composition comprising the polyvalent metal ion compound salt of N,N-dimethylglycine and organic acid or the solvate thereof. The polyvalent metal ion compound salt of N,N-dimethylglycine and organic acid or the solvate thereof provided by the present invention has improvement effect on animal product performance such as improving animal weight gain and reducing feed conversion ratio, showing effects similar to or higher than that of sodium N,N-dimethylglycinate.

Abstract: The present invention relates to a conjugate salt of N,N-dimethylglycine with metal and organic acid, and a preparation method and use thereof. The conjugate salt of N,N-dimethylglycine with metal and organic acid has a following structural formula: [(CH3)2NCH2COO]nM.[Organic acid], wherein, n is 1 or 2; M is selected from an alkali metal ion or a divalent metal ion; the organic acid is selected from an organic polyacid, a C2-C18 linear fatty acid or an aromatic acid. The conjugate salt of N,N-dimethylglycine with metal and organic acid is a conjugate acid salt formed by introducing another organic acid with a hydrophobic group into the salt of N,N-dimethylglycine and a metal ion, so as to modify the hygroscopicity of N,N-dimethylglycine by decreasing the affinity of the salt toward water molecules in the air, or decreasing the affinity or attraction of molecular aggregates formed through crystalline behavior of the salt toward water molecules in the air.

Abstract: A use of a substituted benzoguanidine derivative as a polymyxin antibiotic synergist, particularly as a synergist and a drug resistance reversal agent of the polymyxin antibiotic for inhibiting a sensitive strain, or a composition comprising the same in combination with a polymyxin antibiotic for preparing a compound pharmaceutical preparation for human or animal use in the treatment of a disease caused by a gram-negative bacterial infection or the preparation a growth-promoting feed additive and for the raising of livestock animals.

Abstract: Disclosed are derivatives of 1H-imidazole-4,5-dicarboxamide and use thereof in preparation of anticoccidial drugs. The derivatives have structural formulae as shown in formulae (I) to (VI). The derivatives of 1H-imidazole-4,5-dicarboxamide as disclosed in the present invention have significant anticoccidial effect, especially against coccidia that show a resistance to other anticoccidial drugs, and thus they can be used in preparation of anticoccidial drug.

Abstract: Disclosed is the use of copper-calcium sulphate as an animal feed additive. When used in animal breeding, a low dose of copper-calcium sulphate can achieve a growth promoting effect of a high dosage of copper sulphate, and thus can be used as an animal basic nutritional supplement to substitute low-copper preparations in the breeding of poultry, livestock or aquatic animals. Copper-calcium sulphate, used as a novel, efficient and safe feed additive in the feed processing industry and animal breeding industry, can reduce the dosage of copper ion by nearly 50-70% while maintaining the production, significantly reducing use of copper in husbandry so as to reduce the cost, the poisonous effects and the pollution, making it a promising copper compound.

Abstract: Disclosed are derivatives of 1H-imidazole-4,5-dicarboxamide and use thereof in preparation of anticoccidial drugs. The derivatives have structural formulae as shown in formulae (I) to (VI). The derivatives of 1H-imidazole-4,5-dicarboxamide as disclosed in the present invention have significant anticoccidial effect, especially against coccidia that show a resistance to other anticoccidial drugs, and thus they can be used in preparation of anticoccidial drug.

Abstract: Esters or salts of 2-hydroxy-4-propyleyclohepta-2,4,6-trienone, and applications thereof in preparation of animal antibacterial agents and growth promoters used in feed. The esters or salts of 2-hydroxy-4-propylcyclohepta-2,4,6-trienone has a structural formula as shown in formula 1 or 2: in formula 1, R1 represents heptadecyl; and in formula 2, L is sodium, potassium, calcium, magnesium, zinc, copper or manganese. The esters or salts of 2-hydroxy-4-propyleyclohepta-2,4,6-trienone, as shown in formula 1 or 2, have high stability and safety, and good antibacterial and growth promotion effects, which make them preferable to be used as animal antibacterial agents and growth promoters in feed, and have a very good application prospect in the cultivation industry.

Abstract: Isopropoxy-phenylguanidine series salt as shown by the Formula (I) and an application thereof in preparing growth promoters for animal feed, wherein R is DL-lactic acid, methanesulfonic acid, 2-hydroxyethanesulfonic acid, citric acid, tartaric acid, benzoic acid, succinic acid, fumaric acid, maleic acid, acetic acid, sulfuric acid, phosphoric acid, or oxalic acid.

Abstract: An Application of p-methyl benzoic acid or a salt thereof as an additive for a feed or fed into drinking water for animals such as pigs, broilers, ducks, aquatic animals or other farmed animals, for preventing diarrhea and promoting growth, wherein p-methyl benzoic acid or a salt thereof is a type of acidifying agents for growth promotion.

Abstract: Diaminoguanidine derivatives in preparation of animal growth promoters used in feed. The diaminoguanidine derivatives have a structural formula as shown in formula (I), wherein R1 is methyl, ethyl, isopropyl, n-butyl, n-propyl, n-pentyl, n-octyl, n-tetradecyl, sec-butyl, 3-pentyl, cyclopentyl or benzyl. The diaminoguanidine compounds significantly improve the productivity of ducks if they are fed with the diaminoguanidine compounds. Productivity of pigs or chickens is also improved with such diaminoguanidine compounds.

Abstract: Disclosed are monoesters, inner complex salts or monoester salts of hexahydro-?-acid, and application thereof as animal feed additives. The compounds as shown in formula (I), (II) and (III) show low toxicity or non-toxicity to animals, and have higher stability and better growth promotion effects than those disclosed in other patents, which make them more suitable to be applied as growth promoters used in feed and have a very good application prospect in cultivation industry.

Abstract: Disclosed are monoesters, inner complex salts or monoester salts of hexahydro-?-acid, and application thereof as animal feed additives. The compounds as shown in formula (I), (II) and (III) show low toxicity or non-toxicity to animals, and have higher stability and better growth promotion effects than those disclosed in other patents, which make them more suitable to be applied as growth promoters used in feed and have a very good application prospect in cultivation industry.

Abstract: Diaminoguanidine derivatives in preparation of animal growth promoters used in feed. The diaminoguanidine derivatives have a structural formula as shown in formula (I), wherein R1 is methyl, ethyl, isopropyl, n-butyl, n-propyl, n-pentyl, n-octyl, n-tetradecyl, sec-butyl, 3-pentyl, cyclopentyl or benzyl. The diaminoguanidine compounds significantly improve the productivity of ducks if they are fed with the diaminoguanidine compounds. Productivity of pigs or chickens is also improved with such diaminoguanidine compounds.

Abstract: Esters or salts of 2-hydroxy-4-propyleyclohepta-2,4,6-trienone, and applications thereof in preparation of animal antibacterial agents and growth promoters used in feed. The esters or salts of 2-hydroxy-4-propylcyclohepta-2,4,6-trienone has a structural formula as shown in formula 1 or 2: in formula 1, R1 represents heptadecyl; and in formula 2, L is sodium, potassium, calcium, magnesium, zinc, copper or manganese. The esters or salts of 2-hydroxy-4-propyleyclohepta-2,4,6-trienone, as shown in formula 1 or 2, have high stability and safety, and good antibacterial and growth promotion effects, which make them preferable to be used as animal antibacterial agents and growth promoters in feed, and have a very good application prospect in the cultivation industry.

Abstract: ?-hinokitiol derivatives and application thereof in preparation of animal antibacterial agents and antibacterial growth promoters used in feed. ?-hinokitiol derivatives, having a structural formula as shown in formula (I): wherein, R is n-propyl, n-pentyl, benzyl, sec-butyl, ethyl, n-butyl, p-chlorobenzyl, p-fluorobenzyl, n-octyl, 1-fluoropropyl or n-tetradecyl. The compounds as shown in formula I show low toxicity or non-toxicity to poultry, are safer and have strong growth promotion properties, and therefore are suitable to be used as growth promoters in feed. The compounds have a very good application prospect in cultivation industry.

Abstract: The invention discloses application of an enrofloxacin salt in preparation of an oral preparation for pigs. The enrofloxacin salt is at least one of salts formed by enrofloxacin and metal ions, and the metal ions are zinc, copper, calcium, magnesium, iron, cobalt, manganese, chromium, silver or nickel. The enrofloxacin salt formed by the enrofloxacin and the metal ions can significantly improve the palatability of the enrofloxacin to pigs; furthermore pharmacokinetics and artificial infection prove that the enrofloxacin salt formed by the enrofloxacin and the metal ions does not affect bioavailability, so enrofloxacin salt can be developed into the oral preparation administrated via the digestive tract, for pig-raising without affecting normal feed intake of the pigs.