Patents Assigned to GUANGZHOU INSTITUTE OF RESPIRATORY DISEASE
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Patent number: 10744152Abstract: The present invention discloses an Asarum total polysaccharide extract with antitussive activity, an extraction method thereof and an application in the preparation of a medicine for preventing and treating coughs. The present invention proves that the Asarum total polysaccharide extract has a significant effect of suppressing cough for the first time through a large number of pharmacodynamic tests, has the therapeutic effect approximate to codeine, has the effect of prolonging the cough latent period better than codeine, and also finds that the total Asarum polysaccharide extract has the effects of reducing the cough sensitivity and suppressing the airway inflammation for the first time, has excellent preventive and therapeutic effects on various types of coughs, and can be used for preparing the medicines for preventing and treating cough-related diseases.Type: GrantFiled: June 3, 2018Date of Patent: August 18, 2020Assignees: THE FIRST AFFILIATTED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY, GUANGZHOU INSTITUTE OF RESPIRATORY DISEASEInventors: Kefang Lai, Xiaodong Liu, Bonian Zhong, Shan Zhong, Yichu Nie
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Patent number: 10501470Abstract: The invention discloses a use of asarinin in preparation of medicines for treating various coughs. The asarinin is used for preparing medicines for treating various coughs separately or in combination with other medicines. The asarinin can be extracted by an SFE-CO2 method. The asarinin and usable drug carriers or excipients are made into various formulations. And the formulations are granules, tablets, capsules, soft capsules, pills, dripping pills, ointments, syrups, injection, oral liquid, tinctures, sustained-releasing drugs, controlled release drugs or targeting preparations.Type: GrantFiled: September 4, 2017Date of Patent: December 10, 2019Assignees: THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY, GUANGZHOU INSTITUTE OF RESPIRATORY DISEASEInventors: Kefang Lai, Xiaodong Liu, Bonian Zhong, Shan Zhong, Chuqin Huang
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Patent number: 10251854Abstract: Disclosed are an S-(carboxymethyl)-cysteine pharmaceutical compound (I), and a preparation method and use thereof. Also disclosed are an S-(carboxymethyl)-D-cysteine ammonium salt monohydrate, and use thereof in preparation of medicines for preventing and treating respiratory system diseases such as chronic obstructive pulmonary diseases, in particular in preparation of expectorants. The compounds can reduce airway resistance and production of oxides in rat COPD models, increase the level of antioxidants, and alleviate damage caused by the oxides and inflammatory mediators to lungs.Type: GrantFiled: July 5, 2013Date of Patent: April 9, 2019Assignees: Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd., Baiyunshan Pharmaceutical General Factroy Guangzhou Institute of Respiratory DiseaseInventors: Mao Chen, Shaoxuan Zhu, Ping Wan, Wei Wang, Wei Liao, Hairong Hu, Xianglin Fu, Jin Feng, Binge Huang, Lin Zhang, Nanshan Zhong, Jinping Zheng, Hongying Mo
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Publication number: 20170333374Abstract: Disclosed are an S-(carboxymethyl)-cysteine pharmaceutical compound (I), and a preparation method and use thereof. Also disclosed are an S-(carboxymethyl)-D-cysteine ammonium salt monohydrate, and use thereof in preparation of medicines for preventing and treating respiratory system diseases such as chronic obstructive pulmonary diseases, in particular in preparation of expectorants. The compounds can reduce airway resistance and production of oxides in rat COPD models, increase the level of antioxidants, and alleviate damage caused by the oxides and inflammatory mediators to lungs.Type: ApplicationFiled: July 5, 2013Publication date: November 23, 2017Applicants: Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd., Baiyunshan Pharmaceutical General Factory, Guangzhou Institute of Respiratory DiseaseInventors: Mao Chen, Shaoxuan Zhu, Ping Wan, Wei Wang, Wei Liao, Hairong Hu, Xianglin Fu, Jin Feng, Binge Huang, Lin Zhang, Nanshan Zhong, Jinping Zheng, Hongying Mo
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Publication number: 20170283428Abstract: The invention discloses a method for extracting high-purity asarinin and use thereof. The method comprises: putting crude asarum powder in an SFE-CO2 device; under the conditions that an extraction kettle has a pressure of 30-40 Mpa and a temperature of 45-70° C., separating kettles I and II have a pressure of 5-10 Mpa, a temperature of 30-50° C. and the flow rate of CO2 is 35-60 L/h, extracting for 60-240 min to obtain total volatile oil of asarum; standing the total volatile oil of asarum for 24-72 h at a low temperature, and carrying out suction filtration under reduced pressure to obtain crude asarinin; and re-crystallizing the crude asarinin in absolute ethanol twice to obtain pure asarinin. It is found for the first time that asarinin has a good cough-relieving activity and thus can be used in preparing medicines for treating various types of coughs.Type: ApplicationFiled: April 23, 2017Publication date: October 5, 2017Applicant: GUANGZHOU INSTITUTE OF RESPIRATORY DISEASEInventors: Kefang LAI, Xiaodong LIU, Bonian ZHONG, Shan ZHONG, Chuqin HUANG
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Publication number: 20160339054Abstract: The present invention discloses an Asarum total polysaccharide extract with antitussive activity, an extraction method thereof and an application in the preparation of a medicine for preventing and treating coughs. The present invention proves that the Asarum total polysaccharide extract has a significant effect of suppressing cough for the first time through a large number of pharmacodynamic tests, has the therapeutic effect approximate to codeine, has the effect of prolonging the cough latent period better than codeine, and also finds that the total Asarum polysaccharide extract has the effects of reducing the cough sensitivity and suppressing the airway inflammation for the first time, has excellent preventive and therapeutic effects on various types of coughs, and can be used for preparing the medicines for preventing and treating cough-related diseases.Type: ApplicationFiled: March 25, 2015Publication date: November 24, 2016Applicants: THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY, GUANGZHOU INSTITUTE OF RESPIRATORY DISEASEInventors: Kefang LAI, Xiaodong LIU, Bonian ZHONG, Shan ZHONG, Yichu NIE