Abstract: A handheld high frequency ultrasonic atomizing device for delivering drugs to whole respiratory tract comprising a shell with an air inlet and a lid with a spray nozzle. A drug cup with a piezoelectric transducer and a hood with a spray outlet are provided within the shell. The components of piezoelectric ceramic transducer are as follows (mass percentage): lead tetraoxide 63.3-68.3%, zirconium dioxide 14.2-15.3%, titanium dioxide 8.1-9.5%, strontium oxide 4.6-5.2%, iron sesquioxide 1.5-1.8%, stannic oxide 1.0-1.4%, manganese dioxide 0.3-1.1%, cerium sesquioxide 0.5-0.8%, columbium pentoxide 0.4-0.8% and zinc oxide 0.3-0.7%. This device is small in size, with low power consumption and lower cost, and is able to produce mist with small particle size. The device can efficiently deliver drug liquid into the whole respiratory tract, especially down to the lower respiratory tract and pulmonary alveoli through carrying drug molecules in mist particles.