Abstract: Poly(amino acid) derivatives, which are chelating agents of paramagnetic metal ions, in which at least 3 of the donor nitrogen atoms carry identical or different substituents, of formulaCH(R.sub.1)--X,in which X represents CO.sub.2 R.sub.a, CONR.sub.b R.sub.c or P(R.sub.d)O.sub.2 H and R.sub.a, R.sub.b and R.sub.c, which are identical or different, represent H or optionally hydroxylated (C.sub.1 -C.sub.8)alkyl, R.sub.d represents OH, (C.sub.1 -C.sub.8)alkyl or (C.sub.1 -C.sub.8)alkoxy and R.sub.1 represents a hydrophilic group with a molecular weight greater than 200 containing at least 3 oxygen atoms, with the proviso that at least 3 of the X groups are optionally salified acid functional groups.

Abstract: Iodized polymers, comprising a skeleton consisting of a dextrane onto which are grafted groups of the formula (I). Application of the these compounds as contrast products.

Abstract: The invention concerns gadolinium complexes of formula: ##STR1## in which R represents a group of formula: ##STR2## in which X is Br or I; R.sub.1 is H or optionally hydroxylated alkyl;R.sub.2 is hydroxylated alkyl; oralternatively R.sub.1 is H and R.sub.2 is a group of formula: ##STR3## X being as defined above, and R'.sub.1 and R'.sub.2 being as defined for R.sub.1 and R.sub.2 excepted that they do not represent A, provided that --CO--NR.sub.1 R.sub.2 or --CO--NR'.sub.1 R'.sub.2 comprises at least 2 hydroxyl groups, and M represents H or the cation of an inorganic or organic base.

Abstract: Biological or synthetic macromolecular polyamine compound. optionally of the dendrimer type, characterized in that it carries at least three radio-opaque iodine-containing derivatives.

Abstract: The invention relates to compounds of formula: ##STR1## in which T.sub.i, V.sub.i, T'.sub.i and V'.sub.i with i=0, 1 or 2, represent O, COND or NDCO, D being H, alkyl or (poly)hydroxyalkyl;Q.sub.i and Q'.sub.i with i=0, 1 or 2, represent alkylene or (poly)hydroxyalkylene;Ar.sub.i and Ar'.sub.i with i=1 or 2, represent ##STR2## in which R, R.sub.3, R.sub.4 are COOH and R', R'.sub.3, R'.sub.4 are CONR'.sub.1 R'.sub.2 or N(R'.sub.1)COR'.sub.2, R' and R'.sub.2 being H, alkyl or (poly)hydroxyalkyl such that R'.sub.1 and R'.sub.2 together comprise at least 4 hydroxyl groups,or R.sub.i and R'.sub.i with i=nothing, 3 or 4 represent CONR'.sub.1 R'.sub.2 or N(R'.sub.1)COR'.sub.2, R'.sub.1 and R'.sub.2 together comprising at least 6 hydroxyl groups,or else R.sub.i and R'.sub.i with i=3 or 4 represent T--Q--V--Ar, T, Q and V being as defined above for T.sub.i, Q.sub.i and V.sub.i and Ar having formula II,and A is a biocompatible radical of molecular weight less than 1200 having two valences such as to give with T.sub.

Abstract: The present invention relates to polyiodinated compounds with a single molecular weight having a molecular concentration of iodine of greater than approximately 20% by weight, and in particular greater than approximately 30% by weight, containing at least 9 iodine atoms and having a molecular weight above 2000 and below approximately 50,000, and in particular above 2000 and below approximately 20,000, said compounds possessing either a zero overall electrical charge or at least two anionic charges, and persisting in the vascular compartment at a value equal to at least approximately 30% by weight of the injected dose in a subject five minutes after intravascular administration in the said subject.

Abstract: Poly(amino acid) derivatives, which are chelating agents of paramagnetic metal ions, in which at least 3 of the donor nitrogen atoms carry identical or different substituents, of formulaCH (R.sub.1) --X,in which X represents CO.sub.2 R.sub.a, CONR.sub.b R.sub.c or P(R.sub.d)O.sub.2 H and R.sub.a, R.sub.b and R.sub.c, which are identical or different, represent H or optionally hydroxylated (C.sub.1 -C.sub.8)alkyl, R.sub.d represents OH, (C.sub.1 -C.sub.8)alkyl or (C.sub.1 -C.sub.8)alkoxy and R.sub.1 represents a hydrophilic group with a molecular weight greater than 200 containing at least 3 oxygen atoms, with the proviso that at least 3 of the X groups are optionally salified acid functional groups.

Abstract: Polyiodinated derivatives of formula: ##STR1## in which A is a moiety from an aromatic or aliphatic molecule,Za, Zb, Zc and Zd is Tz-Qz-Vz wherein Tz and Vz are O, COND or NDCO, and D is H or C.sub.1 to C.sub.6 alkyl or hydroxyalkyl and Qz is C.sub.1 to C.sub.6 alkylene or hydroxyalkylene or wherein Vz has the above meanings and Qz and/or Tz do not exist,Xa, Xb, Xc and Xd, which are identical or different, have formula ##STR2## in which Ar and Ar' are tri- or tetraiodinated phenyl groups carrying one or two amide groups substituted by optionally hydroxylated alkyls and T, Q and V have one of the meanings of the Tz, Qz and Vz, or X have, formula ##STR3## in which Ap and A'p have the above formula II and the T, Q and V groups have one of the meanings of the Tz, Qz and Vz.Use of these products as contrast agents in X-ray radiology.

Abstract: A compound of the following formula II ##STR1## in which R.sub.7, R.sub.8, R'.sub.7, R'.sub.8, collectively, contain 10-24 hydroxyl groups and are selected, independently, from H, (C.sub.1 -C.sub.10)alkyl, (C.sub.1 -C.sub.10)alkyl substituted with one or more radicals selected from hydroxyl groups, (C.sub.1 -C.sub.3)alkoxy groups and hydroxylated (C.sub.1 -C.sub.3)alkoxy groups, is useful as a contrast agent in diagnostic X-Ray radiography.

Abstract: The invention relates to ligands having the formula (I), in which X represents a heterocyclic group, together with the process for their preparation. The invention also concerns mono- or polymetallic complexes formed by said ligands with metallic ions selected from lanthanide ions, transition metal ions, barium ion, bismuth ion, lead ion and the radioisotopes 99m.sub.Tc, 111.sub.In, 90.sub.Y, 64.sub.Cu and 169.sub.Yb, as well as salts physiologically acceptable to these complexes. The salts of said complexes can be used as diagnostic and therapeutic agents in magnetic resonance imaging, radiology, in vivo chemical displacement agents and in nuclear medicine.

Abstract: The present invention relates to new polyiodinated compounds of general formula: ##STR1## in which R.sub.1 and R.sub.2, which are identical to or different from each other, represent a group of formula: ##STR2## and R.sub.3 and R.sub.4, which are identical to or different from each other, represent a group of formula ##STR3## with R.sub.1, R.sub.2, R.sub.3 and R.sub.4 comprising in total at least ten hydroxyls, which can be used in contrast media for radiography.The invention also relates to a process for the preparation of these compounds as well as to a contrast medium containing them.

Abstract: The invention relates to novel poly-iodinated compounds of general formula: ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and R.sub.10, identical or different, are selected from an iodine atom, a group of formula ##STR2## provided that at least two of the R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and R.sub.10 groups represent an iodine atom, utilizable in contrast media for radiography. The invention also relates to a process for the preparation of these compounds as well as a contrast medium containing them.

Abstract: Polyiodinated nonionic compound that have the formula: ##STR1##

Abstract: Contrast agent for X-ray imaging, consisting of a halogenated, especially iodinated or brominated, derivative of boron, having characteristics necessary for its use in X-ray imaging. The contrast agent may be used for imaging a corporeal situs by radiological techniques, comprising delivery to the corporeal situs of an imagingly effectively amount of a physiologically acceptable composition comprising the boron reagent. A variety of illustrative boron reagents is described, including vectorised boron derivatives, e.g., boron derivatives encapsulated within liposomes, fixed on or bonded to macromolecules or polymers, etc. The contrast agents, formulations, and method of the present invention may be employed for a wide variety of radiological imaging applications, e.g., excretory urography, angiocardiography, aortography, etc.

Abstract: A diagnostic composition comprising a binuclear complex between a polyaminopolycarboxylic ligand, such as diethylene triamine pentacetic acid, a paramagnetic metal such as Gd and an endogenous metal such as Ca, optionally mixed with the mononuclear complex of the same paramagnetic metal and the same ligand. This composition can be used as a contrasting agent in magnetic resonance imaging.

Abstract: The subject of the invention is nitrogen-containing cyclic ligands and metal complexes formed by these ligands, the uses of these complexes as magnetic resonance imaging (MRI) agents, as X-ray contrast agents and as chemical shift reagents in vivo.

Abstract: An agent for modifying H.sub.2 O relaxation times in NMR diagnosis comprises a polysaccharide having chemically linked to it an organic complexant to which is complexed a paramagnetic metal ion. Polysaccharides include cellulose, starch, sepharose and dextran. Organic complexants include EDTA, DTPA and aminoethyl diphosphonate. A preferred metal ion is Gadolinium (III). The agents can be administered orally or parenterally.

Abstract: The invention relates to ligands of formula ##STR1## in which B represents an ##STR2## W representing the ##STR3## group, in which groups X and Z represent a heterocycle. The invention also relates to the monometallic or polymetallic complexes formed by these ligands with metal ions chosen from lanthanide ions, transition metal ions. barium, bismuth, lead and the radioisotopes .sup.99m Tc, .sup.111 In, .sup.90 Y, .sup.64 Cu and .sup.169 Yb, as well as the physiologically acceptable salts of these complexes.The salts of these complexes may be used as diagnostic or therapeutic agents in nuclear magnetic resonance imaging and X-ray radiology, as in-vivo chemical shift agents and in nuclear medicine.

Abstract: A polysaccharide chemically joined to a nitroxyl spin label (NSL) compound has use for the preparation of an NMR diagnostic composition. An agent for modifying H.sub.2 O relaxation times in NMR diagnosis may comprise a polysaccharide to which is chemically linked both an NSL compound and an organic complexing agent to which is complexed a paramagnetic metal ion, such as Gd(III) or Cu(II). Polysaccharides include dextran, starch and cellulose. The preferred NSL compound is 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl.

Abstract: The subject of the invention is nitrogen-containing cyclic ligands and metal complexes formed by these ligands, the uses of these complexes as magnetic resonance imaging (MRI) agents, as X-ray contrast agents and as chemical shift reagents in vivo.