Patent number: 6380211
Abstract: A compound, compositions, methods of use, and processes of making formula I:
or a pharmaceutically acceptable salt, hydrate, ester, solvate, prodrug, metabolite, stereoisomer, or mixtures thereof, wherein:
R1, when present, is hydrogen or lower alkyl;
R2 is lower alkyl, aryl, aralkyl, lower alkanoyl, or —(CH2)n—(CHOH)y(CH2)mA, wherein n is 1-4, y is 0 or 1, m is 0-5, and A is cycloalkyl, cycloalkenyl, lower alkanoyl, aryl, aralkyl, —NH2, —NH—(lower alkyl),
Y represents the atoms necessary to form a fused 5- to 6-membered ring that is aromatic or nonaromatic and carbocyclic or heterocyclic;
Z is
(i) —CHR2CHR3— where R2 and R3 are independently hydrogen, alkyl, aryl or aralkyl;
(ii) —R6C═CR3— where R6 and R3 are independently hydrogen, lower alkyl, aryl, aralkyl, chlorine, bromine or —NR7R8, where R7 and R8 are independently hydrogen or lower alkyl, or, R6 and R3, taken together, form a fused 5- to 6-member
Type:
Grant
Filed:
November 15, 2000
Date of Patent:
April 30, 2002
Assignee:
Guilford Pharmaceutical Inc.
Inventors:
Paul F. Jackson, Keith M. Maclin, Jie Zhang