Abstract: Reagents, methods, and kits for the classification of cancer that comprise or employ antibodies that bind specific regions of CD43. One method includes contacting tissue with an antibody capable of specifically binding the cytoplasmic tail of CD43, contacting the tissue with an antibody capable of specifically binding the extracellular domain of CD43, and resolving cellular localization of any binding to the tissue with the antibody capable of specifically binding the cytoplasmic tail of CD43 and the antibody capable of specifically binding the extracellular domain of CD43. The binding patterns of the antibodies can be used to characterize cancer as more aggressive or less aggressive and can distinguish small cell lung cancer from non-small cell lung cancer. The cancer may therefore be treated in accordance of the characterization.
Type:
Grant
Filed:
April 2, 2013
Date of Patent:
April 7, 2015
Assignee:
Gundersen Lutheran Health System
Inventors:
Carl S. Shelley, Steven E. Cash, Jeremiah J. Andersen, Qiangwei Fu
Abstract: A system and method of cleaning and scrubbing contaminants, including sulfides, from an unclean or raw gas includes one or more containers, each of which include a gas permeable receptacle or bag containing an appropriate gas scrubbing medium for removing the contaminants from the gas stream. A gas extraction device is adapted via inserted into the gas scrubbing medium with the gas permeable receptacle wherein the gas extraction device is connected to at least one gas outlet port in the container. A series of containers can be used wherein the containers are connected sequentially to remove the gas. A system for bypassing one of the plurality of containers in order to clean out the container while the gas cleaning mechanism is still in operation is also described.
Abstract: A system and method of cleaning and scrubbing contaminants, including sulfides, from an unclean or raw gas includes one or more containers, each of which include a gas permeable receptacle or bag containing an appropriate gas scrubbing medium for removing the contaminants from the gas stream. A gas extraction device is adapted via inserted into the gas scrubbing medium with the gas permeable receptacle wherein the gas extraction device is connected to at least one gas outlet port in the container. A series of containers can be used wherein the containers are connected sequentially to remove the gas. A system for bypassing one of the plurality of containers in order to clean out the container while the gas cleaning mechanism is still in operation is also described.
Abstract: Reagents, methods, and kits for the classification of cancer that comprise or employ antibodies that bind specific regions of CD43. One method includes contacting tissue with an antibody capable of specifically binding the cytoplasmic tail of CD43, contacting the tissue with an antibody capable of specifically binding the extracellular domain of CD43, and resolving cellular localization of any binding to the tissue with the antibody capable of specifically binding the cytoplasmic tail of CD43 and the antibody capable of specifically binding the extracellular domain of CD43. The binding patterns of the antibodies can be used to characterize cancer as more aggressive or less aggressive and can distinguish small cell lung cancer from non-small cell lung cancer. The cancer may therefore be treated in accordance of the characterization.
Type:
Application
Filed:
April 2, 2013
Publication date:
October 3, 2013
Applicant:
Gundersen Lutheran Health System
Inventors:
Carl S. Shelley, Steven E. Cash, Jeremiah J. Andersen, Qiangwei Fu