Abstract: The present invention includes methods and compositions for the differentiation of stem cells and enhancement of stem cell therapies. In certain embodiments, the present invention includes methods and compositions of autoimmune T-cells reactive to the desired cell type or types cultured with stem cells to induce differentiation of the stem cells to the desired cell type or types. In certain other embodiments, the present invention includes methods of enhancing stem cell therapies by administration to a subject of autoimmune T-cells reactive to the cell type or types useful for cell therapies.