Abstract: A pointing device is disclosed comprising a motion translation unit and one or more physiological response sensors. The motion translation unit identifies and communicates changes in the position of the pointing device to a communicatively coupled host system. In accordance with the teachings of the present invention, the one or more physiological response sensors measure and communicate physiological response information of a user of the pointing device to the host system. In accordance with a second aspect of the present invention, a host system incorporating the teachings of the present invention utilizes physiological response information to modify the operating environment of the host system to suit the physiological state of the host system user.