Patents Assigned to Gwo Xi Stem Cell Applied Technology Co., Ltd.
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Patent number: 11739044Abstract: The present invention relates to a method for synthesizing artepillin C and a synthetic method for synthesizing an intermediate compound for use in preparing artepillin C. The structural formula of artepillin C is shown in the following formula (IV), and the intermediate compound is shown in the following formula (II). The synthesis method includes the following steps: a first reaction step: in the presence of a base initiator, a compound A shown in formula I and 3,3-dimethylallyl bromide are mixed, the reaction continues for a first reaction time and is stopped to generate an intermediate of artepillin C shown in formula II; and a second reaction step: the intermediate of artepillin C is dissolved in an aqueous alcohol solution and then mixed with an alkali metal salt, and the reaction continues for a second reaction time to generate artepillin C.Type: GrantFiled: February 23, 2021Date of Patent: August 29, 2023Assignee: GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD.Inventors: Ming-Hsi Chuang, Lin-Hsiang Chuang, Ming-Hsuan Lu, Wen-Peng Shen, Yun-Chen Lin, Chi-Hsuan Chuang
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Patent number: 11020358Abstract: A method for the anti-senescence of and/or rejuvenating a stem cell is provided. The method comprising treating the stem cell with trans-cinnamaldehyde (TC). A kit is also provided. The kit comprising (1) a first part, comprising a stem cell; (2) a second part, comprising TC; and (3) a culture medium of the stem cell, placed in at least one of the first part, the second part, and a third part. In addition, a method for stem cell therapy is provided. The method comprising administering to a subject in need an effective amount of a stem cell, wherein the stem cell has been treated with TC before being administered.Type: GrantFiled: May 11, 2017Date of Patent: June 1, 2021Assignee: GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD.Inventors: Tzyy-Wen Chiou, Horng-Jyh Harn, Shinn-Zong Lin, Karthyayani Rajamani, Yi-Chun Lin
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Patent number: 10639264Abstract: A mesenchymal stem cell extract and its use are provided, wherein the mesenchymal stem cell extract comprises a trophic factor(s), such as bone morphogenetic protein-7 (BMP-7), stromal cell-derived factor-1 (SDF-1), vascular endothelial growth factor (VEGF), C-X-C chemokine receptor type-4 (CXCR4), brain-derived neurotrophic factor (BDNF), and/or interleukin-17 (IL-17), and wherein the extract is especially suitable for repairing skin aging.Type: GrantFiled: May 15, 2018Date of Patent: May 5, 2020Assignee: GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD.Inventors: Shinn-Zong Lin, Horng-Jyh Harn, Tzyy-Wen Chiou, Po-Cheng Lin
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Patent number: 10022313Abstract: A mesenchymal stem cell extract and its use are provided, wherein the mesenchymal stem cell extract comprises a trophic factor(s), such as bone morphogenetic protein-7 (BMP-7), stromal cell-derived factor-1 (SDF-1), vascular endothelial growth factor (VEGF), C-X-C chemokine receptor type-4 (CXCR4), brain-derived neurotrophic factor (BDNF), and/or interleukin-17 (IL-17), and wherein the extract is especially suitable for repairing skin aging.Type: GrantFiled: July 2, 2014Date of Patent: July 17, 2018Assignee: GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD.Inventors: Shinn-Zong Ling, Horng-Jyh Harn, Tzyy-Wen Chiou, Po-Cheng Lin
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Patent number: 9815959Abstract: A method for manufacturing a hollow particle is provided. The method comprises the steps of (a) providing a hollow particulate; (b) soaking the hollow particulate in an amine solution to form amine groups on the surface of the hollow particulate; (c) adding a polypeptide, and the polypeptide is linked to the amine groups on the surface of the hollow particulate; and (d) adding a target molecule, and the target molecule is bound to the amine group which are still not bound.Type: GrantFiled: February 26, 2015Date of Patent: November 14, 2017Assignee: GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD.Inventors: Jui-Yang Lai, Kao-Yuan Chang, Zih-Han Hong, Po-Cheng Lin, Ming-Hsi Chuang
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Patent number: 9533012Abstract: A method for enhancing the therapeutic effect of a stem cell is provided. The method comprises treating the stem cell with ligustilide, wherein the treatment is conducted in a culture medium of the stem cell. A method of stem cell treatment is also provided, comprising administering to a subject in need an effective amount of a stem cell or a combination of ligustilide and a stem cell, wherein the stem cell has been treated with ligustilide.Type: GrantFiled: November 24, 2014Date of Patent: January 3, 2017Assignee: GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD.Inventors: Shinn-Zong Lin, Horng-Jyh Harn, Ru-Huei Fu, Shih-Ping Liu, Po-Cheng Lin, Ming-Hsi Chuang
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Patent number: 9523081Abstract: A method for enhancing the therapeutic effect of a stem cell on autoimmune diseases, cardiovascular diseases, and/or hematological diseases is provided. The method comprises treating the stem cell with ligustilide, wherein the treatment is conducted in a culture medium of the stem cell. A method of stem cell treatment is also provided, comprising administering to a subject suffering from autoimmune diseases, cardiovascular diseases, and/or hematological diseases an effective amount of a stem cell or a combination of ligustilide and a stem cell, wherein the stem cell has been treated with ligustilide.Type: GrantFiled: August 7, 2015Date of Patent: December 20, 2016Assignee: GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD.Inventors: Shinn-Zong Lin, Horng-Jyh Harn, Ru-Huei Fu, Shih-Ping Liu, Po-Cheng Lin, Ming-Hsi Chuang
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Patent number: 9518251Abstract: A method for enhancing the therapeutic effect of stem cells on autoimmune diseases, cardiovascular diseases, and/or hematological diseases is provided. The method comprises pre-treating the stem cells with ligustilide to increase the expression of differentiation-promoting genes in the stem cells, increase the expression of homing-promoting genes in the stem cells, and/or decrease the expression of inflammatory genes in the stem cells, wherein the treatment is conducted in a culture medium of the stem cell.Type: GrantFiled: March 18, 2016Date of Patent: December 13, 2016Assignee: GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD.Inventors: Shinn-Zong Lin, Horng-Jyh Harn, Ru-Huei Fu, Shih-Ping Liu, Po-Cheng Lin, Ming-Hsi Chuang
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Publication number: 20130309317Abstract: The present invention provides a food supplement, which comprises: a placental extract and an oil; which would promote the proliferation of CD34+ stem cells and increase the telomerase activity to achieve rejuvenation and anti-aging.Type: ApplicationFiled: September 4, 2012Publication date: November 21, 2013Applicant: GWO XI STEM CELL APPLIED TECHNOLOGY CO. LTD.Inventors: HORNG-JYH HARN, SHINN-ZONG LIN, PO-CHENG LIN, HSIN-I WANG, PI-CHUN HUANG
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Patent number: 8415149Abstract: Disclosed are cells, compositions, and methods for treating liver diseases.Type: GrantFiled: May 6, 2010Date of Patent: April 9, 2013Assignee: Gwo Xi Stem Cell Applied Technology Co., Ltd.Inventors: Horng-Jyh Harn, Shinn-Zong Lin