Abstract: A bondable blood-friendly polymer is a terpolymer or a quadripolymer at least formed by polyethylene glycol alkyl ether acrylate or polyethylene glycol alkyl ether methacrylate (I), and zwitterionic acrylic ester or zwitterionic methacrylic ester (II), and acrylic acid or a methacrylate derivative with an epoxypropyl group, an isocyanate group, a trialkoxy silane, a hydroxyalkyl group, a propargyl group or a quaternary ammonium group (III). In the present invention, the blood-friendly polymer with a potentially-bondable group has the following advantages: although the water insolubility thereof is implemented by using the hydrophobicity physical effect of an existing higher alkyl acrylate linkage, the blood friendliness of a coating is reduced due to the existence of a great number of hydrophobic chain links in the polymer; and a physical coating is slowly desolventized from the surface to be ablated in the application process of the physical coating.