Abstract: Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of an E-selectin to an E-selectin ligand are disclosed. For example, haloalkyl fucose-containing E-selectin antagonists and compositions comprising at least one such agent are described.
Type:
Application
Filed:
May 22, 2017
Publication date:
October 8, 2020
Applicant:
GycoMimetics, Inc.
Inventors:
Beat ERNST, Norbert VARGA, Martin SMIESKO, Beatrice WAGNER, John M. PETERSON, John L. MAGNANI