Abstract: The present invention relates to novel benzylideneacetone derivatives or uses thereof, more specifically, the present invention relates to a pharmaceutical composition for preventing or treating, or food composition for ameliorating a cancer or a bone disease comprising a compound defined by Formula 1 or pharmaceutically acceptable salt thereof as an active ingredient.
Type:
Grant
Filed:
July 27, 2018
Date of Patent:
April 18, 2023
Assignees:
KORPHARM CO., LTD., GYEONGGIDO BUSINESS & SCIENCE ACCELERATOR, KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
Inventors:
Gil Hong Park, Jin Mo Ku, Jung Hun Lee, Da Woon Song, Serk In Park, Han Kyeom Kim, Soon Hyuck Lee, Hong Kyu Kim, Pativada Triveni, Myung Hwan Kim
Abstract: The present invention relates to an amide derivative compound or a pharmaceutically acceptable salt thereof, which can be beneficially used in the treatment or prevention of Middle East Respiratory Syndrome (MERS). In addition, the present invention relates to a pharmaceutical composition for treating or preventing MERS, comprising said compound or a pharmaceutically acceptable salt thereof.
Type:
Application
Filed:
February 3, 2020
Publication date:
December 1, 2022
Applicant:
GYEONGGIDO BUSINESS & SCIENCE ACCELERATOR
Inventors:
Jin-Mo KU, Kwi-Wan JEONG, Seung-Young JUNG
Abstract: The present invention relates to a novel triazole derivative or a salt thereof. The triazole derivative or the salt thereof according to the present invention induces or promotes browning of white adipocytes, and differentiates stem cells, embryonic cells, or preadipocytes to brown adipocytes or beige adipocytes. A composition comprising the triazole derivative or the salt thereof according to the present invention can treat, prevent or alleviate obesity, obesity complications, diabetes, dyslipidemia, fatty liver, hypertension, metabolic syndrome, and insulin resistance syndrome.
Type:
Application
Filed:
December 20, 2017
Publication date:
June 3, 2021
Applicant:
GYEONGGIDO BUSINESS & SCIENCE ACCELERATOR
Inventors:
Jin-Mo KU, Jin-Kyung IN, Jung-Hun LEE, Han-Na CHA
Abstract: A composition for inducing differentiation into beige adipocytes from white adipocytes, including butein, a butein derivative, or a pharmaceutically available salt thereof as an active ingredient, and a method of inducing the differentiation are provided. Increases in expressions of UCP-1 and PRDM4 are confirmed using the active ingredient, that is, the butein or butein derivative, and therefore the composition is expected to be used in preventing or treating obesity, and more basically, for target treatment.
Type:
Grant
Filed:
December 9, 2016
Date of Patent:
January 30, 2018
Assignees:
Research & Business Foundation Sungkyunkwan University, GYEONGGIDO BUSINESS & SCIENCE ACCELERATOR
Inventors:
Kye Won Park, Nojoon Song, Suk Chan Lee, Jin-Mo Ku