Abstract: A cervical tissue sampling device to allow women to collect tissue samples at home for transmission to a laboratory by mail or other means includes a cylindrical barrel having an open circular front end and an open circular rear end terminating in a radially extending irregularly shaped finger grip flange. A plunger assembly slidably received within the barrel includes a circular brush and surrounding circular sponge for collecting cervical tissue and mucous. The brush and sponge collection assembly is detachably secured to the plunger shaft by a quick release connection. In use, the barrel is inserted by a female into her vagina with the sponge and brush disposed in a retracted condition within the barrel 12. After insertion, the plunger is moved to an extended condition and rotated to collect tissue and mucous samples on the brush and sponge. After the samples have been collected, the sponge and brush are detached from the plunger shaft and mailed in a sealed container to a laboratory for analysis.