Abstract: Disclosed herein are compounds that are inhibitors of BRD4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BRD4 are also disclosed. In certain aspects, disclosed are compounds of Formula I-IV.
Type:
Grant
Filed:
August 3, 2015
Date of Patent:
October 23, 2018
Assignee:
H. Lee Moffitt Cancer Center and Research Insitute, Inc.
Inventors:
Ernst Shönbrunn, Nicholas J. Lawrence, Harshani R. Lawrence