Abstract: Ink-jet printing technology is applied to the creation of multi unit chemical compound libraries. Ink-jet type nozzles are used to inject multiple droplets onto the surface an appropriate support, such droplets consisting of solutions containing units of the chemical compound that will attach to the support surface. Droplets are then injected, by such nozzles, onto the support attached unit droplets that contain units that will attach to such support attached units. The second step is repeated to create multiple varying unit chemical compounds. Ink-jet printing technology allows the deposition of small droplets that do not overlap or splatter. The system is particularly useful in the creation of libraries of multiple peptide compounds where the units are amino acids.

Abstract: The present invention is an improved method of making sequenced chemical chain compounds through the application of laser copy technology to UV light directed spatially addressed parallel chemical synthesis and is particularly useful in the production of numerous proteins of varying amino acid sequences on a restricted solid support. Chemical groups, such as amines, are attached to the surface of a solid sup- port, such as flat glass, and subjected to chemical reaction disposed to link chemical units to the attached groups that are protected from further reaction by photolabile groups. Such solid support and photolabile protected units are then selectively deprotected by irradiation with a UV laser beam. The support and attached units are then subjected to chemical reaction to link chemical units to the selectively deprotected units. By repeated such treatment it is possible to produce unlimited combinations of chain chemical units in less time and at greater efficiency than has previously been possible.