Patents Assigned to Haase Investments UG
  • Bone morphogenetic protein 2 (BMP2) variants with reduced BMP antagonist sensitivity
    Patent number: 8828937
    Abstract: The present invention is directed to an isolated peptide comprising or consisting of an amino acid sequence with an amino acid identity of at least 90% compared to mature human BMP2 with SEQ ID No. 1, characterized in that said amino acid sequence comprises at least two amino acid substitutions characterized in that a first amino acid substitution occurs at a position corresponding to N59, S88, E94, V99, K101 and/or N102 of SEQ ID No. 1 and to uses thereof.
    Type: Grant
    Filed: March 11, 2010
    Date of Patent: September 9, 2014
    Assignee: Haase Investments UG
    Inventors: Petra Seemann, Stefan Mundlos, Carsten Reissner, Georg Duda, Julia Zimmer